Results 11 to 20 of about 287,328 (279)

Post-transcriptional Processing of mRNA in Neurons: The Vestiges of the RNA World Drive Transcriptome Diversity

Frontiers in Molecular Neuroscience, 2018
Neurons are morphologically complex cells that rely on the compartmentalization of protein expression to develop and maintain their extraordinary cytoarchitecture.
Catia Andreassi, Hamish Crerar, Antonella Riccio   +2 more
doaj   +5 more sources

Inhibition of post-transcriptional RNA processing by CDK inhibitors and its implication in anti-viral therapy.

PLoS ONE, 2014
Cyclin-dependent kinases (CDKs) are key regulators of the cell cycle and RNA polymerase II mediated transcription. Several pharmacological CDK inhibitors are currently in clinical trials as potential cancer therapeutics and some of them also exhibit ...
Jitka Holcakova, Petr Muller, Peter Tomasec, Roman Hrstka, Marta Nekulova, Vladimir Krystof, Miroslav Strnad, Gavin W G Wilkinson, Borivoj Vojtesek   +8 more
doaj   +6 more sources

Editorial: RNA at a breaking point? Cytoplasmic cleavage and other post-transcriptional RNA processing in neurodevelopment and disease

Frontiers in Molecular Neuroscience, 2023
Monika Piwecka, Raphaelle Luisier, Raphaelle Luisier, Catia Andreassi   +3 more
doaj   +3 more sources

Single Molecule Imaging In Vivo Determines Post-Transcriptional RNA Processing Dynamics [PDF]

Biophysical Journal, 2014
The synthesis and splicing of pre-mRNA to form completed transcripts requires coordination between two large multi-subunit complexes (the RNA polymerase and the spliceosome). Using dual color single molecule RNA imaging in living human cells, we previously observed kinetic competition during the transcription cycle which resulted in both co- and post ...
Ferguson, Matthew L., Coulon, Antoine, de Turris, Valeria, Palangat, Murali, Chow, Carson C., Larson, Daniel R.   +5 more
openaire   +3 more sources

Post-transcriptional processing generates a diversity of 5′-modified long and short RNAs [PDF]

Nature, 2009
The transcriptomes of eukaryotic cells are incredibly complex. Individual non-coding RNAs dwarf the number of protein-coding genes, and include classes that are well understood as well as classes for which the nature, extent and functional roles are obscure. Deep sequencing of small RNAs (
Fejes-Tóth, Katalin, Sotirova, Vihra, Sachidanandam, Ravi, Assaf, Gordon, Hannon, Gregory J., Kapranov, Philipp, Foissac, Sylvain, Willingham, Aarron T., Duttagupta, Radha, Dumais, Erica, Gingeras, Thomas R., Affymetrix/Cold Spring Harbor Laboratory ENCODE Transcriptome Project   +11 more
openaire   +6 more sources

Differential polyadenylation of ribosomal RNA during post-transcriptional processing inLeishmania [PDF]

Parasitology, 2005
The protozoan parasiteLeishmaniabelongs to the most ancient eukaryotic lineages and this is reflected in several distinctive biological features, such as eukaryotic polycistronic transcription and RNA trans-splicing. The disclosure of this organism's unusual characteristics leads to a better understanding of the origin and nature of fundamental ...
Decuypere, S., Vandesompele, J., Yardley, V., De Doncker, S., Laurent, T., Rijal, S., Llanos-Cuentas, A., Chappuis, F., Arevalo, J., Dujardin, J. C.   +9 more
openaire   +4 more sources

Role of Sam68 in post-transcriptional gene regulation [PDF]

, 2013
The STAR family of proteins links signaling pathways to various aspects of post-transcriptional regulation and processing of RNAs. Sam68 belongs to this class of heteronuclear ribonucleoprotein particle K (hnRNP K) homology (KH) single domain-containing ...
Anderson, Andreotti, Arning, Auboeuf, Babic, Babic, Baehrecke, Barlat, Batsche, Bedford, Berson, Biamonti, Biamonti, Bianchi, Bielli, Burd, Busa, Busa, Chawla, Chen, Chen, Chen, Chen, Cheng, Cote, Cruz-Alvarez, Denegri, Derry, Di Fruscio, Di Fruscio, Dreyfuss, Ebersole, Finnen, Flora Sánchez-Jiménez, Fumagalli, Fusaki, Galarneau, Grossman, Guitard, Hartmann, Hawkins, Henao-Mejia, Hong, Huot, Huot, Iijima, Ishidate, Itoh, Jabado, Jauliac, Jones, Kim, Klein, Kunkel, Lang, Lawe, Li, Liao, Lin, Liu, Locatelli, Locatelli, Lukong, Lukong, Lukong, Lukong, Lynch, Maa, Martin-Romero, Matter, Messina, Meyer, Mezquita, Modem, Morishita, Najib, Najib, Naor, Paronetto, Paronetto, Paronetto, Paronetto, Paronetto, Paronetto, Pedrotti, Pedrotti, Piotrowska, Porkka, Rajan, Rajan, Ramakrishnan, Reddy, Resnick, Richard, Richard, Richard, Rosenberger, Ru, Sanchez-Jimenez, Sanchez-Jimenez, Sanchez-Margalet, Sanchez-Margalet, Sanchez-Margalet, Sanchez-Margalet, Sanchez-Margalet, Sellier, Sette, Simarro, Song, Soros, Stoss, Subramanyam, Suhasini, Tassone, Taylor, Taylor, Taylor, Tisserant, Tremblay, Trub, Ulke-Lemee, Valacca, Venables, Venigalla, Vernet, Víctor Sánchez-Margalet, Wang, Wang, Yang, Zhang, Zorn   +130 more
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Computational prediction of RNA structural motifs involved in posttranscriptional regulatory processes [PDF]

Proceedings of the National Academy of Sciences, 2008
Messenger RNA molecules are tightly regulated, mostly through interactions with proteins and other RNAs, but the mechanisms that confer the specificity of such interactions are poorly understood. It is clear, however, that this specificity is determined by both the nucleotide sequence and secondary structure of the mRNA.
Michal Rabani, Michael Kertesz, Eran Segal   +2 more
openaire   +5 more sources

Circular RT-PCR Assay Using Arabidopsis Samples

Bio-Protocol, 2015
Post-transcriptional processing is critical for RNA biogenesis, in which conventional functional RNA transcripts are generated, such as messenger RNAs (mRNAs), transfer RNAs (tRNAs) and ribosomal RNAs (rRNAs) for translation as well as emerging non ...
Runlai Hang, Xian Deng, Chunyan Liu, Beixin Mo, Xiaofeng Cao   +4 more
doaj   +1 more source

Complex RNA metabolism in the chloroplast: an update on the psbB operon [PDF]

, 2012
Expression of most plastid genes involves multiple post-transcriptional processing events, such as splicing, editing, and intercistronic processing. The latter involves the formation of mono-, di-, and multicistronic transcripts, which can further be ...
Jörg Meurer, Rhea Stoppel
core   +1 more source