Results 71 to 80 of about 287,328 (279)

RNA Metabolism and the Role of Small RNAs in Regulating Multiple Aspects of RNA Metabolism

Non-Coding RNA
RNA metabolism is focused on RNA molecules and encompasses all the crucial processes an RNA molecule may or will undergo throughout its life cycle. It is an essential cellular process that allows all cells to function effectively.
Pranav Dawar, Indra Adhikari, Swarupa Nanda Mandal, Bhumika Jayee   +3 more
doaj   +1 more source

Applications of Recombinant Dna Technology in Gastrointestinal Medicine and Hepatology: Basic Paradigms of Molecular Cell Biology. Part B: Eukaryotic Gene Transcription and Post-Transcripional Rna Processing [PDF]

Canadian Journal of Gastroenterology, 2000
The transcription of DNA into RNA is the primary level at which gene expression is controlled in eukaryotic cells. Eukaryotic gene transcription  involves several different RNA polymerases that interact with a host of transcription factors to initiate transcription.
Alan B. R. Thomson, Gary Wild, Patrizia Papalia, Mark J Ropeleski, Julio Faria   +4 more
openaire   +4 more sources

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Dynamic landscape of m6A modifications and related post-transcriptional events in muscle-invasive bladder cancer

Journal of Translational Medicine
Background Muscle-invasive bladder carcinoma (MIBC) is a serious and more advanced stage of bladder carcinoma. N6-Methyladenosine (m6A) is a dynamic and reversible modifications that primarily affects RNA stability and alternative splicing.
Lili Zhang, Ziwei Chen, Gaoyuan Sun, Chang Li, Pengjie Wu, Wenrui Xu, Hui Zhu, Zaifeng Zhang, Yongbin Tang, Yayu Li, Yifei Li, Siyuan Xu, Hexin Li, Meng Chen, Fei Xiao, Yaqun Zhang, Wei Zhang   +16 more
doaj   +1 more source

Cell type-specific CLIP reveals that NOVA regulates cytoskeleton interactions in motoneurons

Genome Biology, 2018
Background Alternative RNA processing plays an essential role in shaping cell identity and connectivity in the central nervous system. This is believed to involve differential regulation of RNA processing in various cell types.
Yuan Yuan, Shirley Xie, Jennifer C. Darnell, Andrew J. Darnell, Yuhki Saito, Hemali Phatnani, Elisabeth A. Murphy, Chaolin Zhang, Tom Maniatis, Robert B. Darnell   +9 more
doaj   +1 more source

Retroviral RNA Processing

Viruses, 2022
This review is an accompaniment to a Special Issue on “Retroviral RNA Processing”. It discusses post-transcriptional regulation of retroviruses, ranging from the ancient foamy viruses to more modern viruses, such as HIV-1, HTLV-1, Rous sarcoma virus ...
Karen L. Beemon
doaj   +1 more source

A Database for TSSs of Human MicroRNAs [PDF]

, 2012
MicroRNAs (miRNAs) are small endogeneous non-coding RNAs of about 22nt length. These short RNAs regulate the expression of mRNAs by hybridizing with their 3'-UTRs or by translational repression.
Malay Bhattacharyya, Sanghamitra Bandyopadhyay   +1 more
core   +2 more sources

Saccharomyces cerevisiae U14 small nuclear RNA has little secondary structure and appears to be produced by post-transcriptional processing.

Journal of Biological Chemistry, 1994
Yeast U14 small nuclear (sn) RNA is required for normal processing of rRNA. The sequence and folding properties of U14 were analyzed in the present study, with the aim of defining the structures of natural U14 subspecies and characterizing the folding properties of free U14 RNA.
A G Balakin, Maurille J. Fournier, R A Lempicki, G M Huang   +3 more
openaire   +3 more sources

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

RNA-Binding Proteins: The Key Modulator in Stress Granule Formation and Abiotic Stress Response

Frontiers in Plant Science, 2022
To cope with abiotic environmental stress, plants rapidly change their gene expression transcriptionally and post-transcriptionally, the latter by translational suppression of selected proteins and the assembly of cytoplasmic stress granules (SGs) that ...
Yanyan Yan, Jianghuang Gan, Yilin Tao, Thomas W. Okita, Li Tian   +4 more
doaj   +1 more source