Multi-agent approach to sequence structure simulation in the RNA World hypothesis. [PDF]
PLoS ONE, 2020 The origins of life on Earth have been the subject of inquiry since the early days of philosophical thought and are still intensively investigated by the researchers around the world.
Jaroslaw Synak +2 more
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A Hypothesis: Life Initiated from Two Genes, as Deduced from the RNA World Hypothesis and the Characteristics of Life-Like Systems [PDF]
Life, 2016 RNA played a central role in the emergence of the first life-like system on primitive Earth since RNA molecules contain both genetic information and catalytic activity. However, there are several drawbacks regarding the RNA world hypothesis.
Kunio Kawamura
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The RNA world hypothesis: the worst theory of the early evolution of life (except for all the others)a [PDF]
Biology Direct, 2012 The problems associated with the RNA world hypothesis are well known. In the following I discuss some of these difficulties, some of the alternative hypotheses that have been proposed, and some of the problems with these alternative models.
Bernhardt Harold S
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Development of a Functionally Minimized Mutant of the R3C Ligase Ribozyme Offers Insight into the Plausibility of the RNA World Hypothesis [PDF]
Biology, 2014 The R3C ligase ribozyme is an artificial ligase ribozyme produced by modification of the ribozyme that lacks cytidine. Here, we attempted to modify the original R3C ribozyme (73 nucleotides) by reducing the number of nucleotides while maintaining the ...
Eri Kurihara +3 more
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tRNA Core Hypothesis for the Transition from the RNA World to the Ribonucleoprotein World [PDF]
Life, 2016 Herein we present the tRNA core hypothesis, which emphasizes the central role of tRNAs molecules in the origin and evolution of fundamental biological processes.
Savio T. de Farias +2 more
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The RNA World: Piecing together the historical development of a hypothesis
Mètode Science Studies Journal: Annual Review, 2016 The concept of an RNA world is a hypothesis firmly rooted in empirical data and is part of a long and complex scientific perspective that goes back more than fifty years to the discovery of the central role RNA and ribonucleotides play in protein ...
Antonio Lazcano
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Editorial: RNA world hypothesis and the origin of life: Astrochemistry perspective [PDF]
Frontiers in Astronomy and Space Sciences, 2022 Ashraf Ali +2 more
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Aminoacylating urzymes challenge the RNA world hypothesis. [PDF]
J Biol Chem, 2013 We describe experimental evidence that ancestral peptide catalysts substantially accelerated development of genetic coding. Structurally invariant 120–130-residue Urzymes (Ur = primitive plus enzyme) derived from Class I and Class II aminoacyl-tRNA synthetases (aaRSs) acylate tRNA far faster than the uncatalyzed rate of nonribosomal peptide bond ...
Li L, Francklyn C, Carter CW.
europepmc +6 more sources
A Faster Triphosphorylation Ribozyme. [PDF]
PLoS ONE, 2015 In support of the RNA world hypothesis, previous studies identified trimetaphosphate (Tmp) as a plausible energy source for RNA world organisms. In one of these studies, catalytic RNAs (ribozymes) that catalyze the triphosphorylation of RNA 5'-hydroxyl ...
Gregory F Dolan +2 more
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Differential stability and dynamics of DNA-based and RNA-based coacervates affect non-enzymatic RNA chemistry [PDF]
Nature CommunicationsThe RNA-peptide world hypothesis postulates the early co-evolution of RNA and peptides that led to the emergence of non-enzymatic RNA replication and peptide synthesis.
Karina K. Nakashima +11 more
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