Diverse impacts of different rpoB mutations on the anti-tuberculosis efficacy of capreomycinResearch in context [PDF]
EBioMedicineSummary: Background: Since the discovery of streptomycin in the 1940s, more than a dozen drugs have been continuously introduced into tuberculosis (TB) therapy.
Jin-Tian Xu +7 more
doaj +4 more sources
Molecular characterization of rpoB gene mutations in isolates from tuberculosis patients in Cubal, Republic of Angola [PDF]
BMC Infectious Diseases, 2021 Background The importance of Mycobacterium tuberculosis strains with disputed rpoB mutations remains to be defined. This study aimed to assess the frequency and types of rpoB mutations in M. tuberculosis isolates from Cubal, Angola, a country with a high
Ariadna Rando-Segura +17 more
doaj +2 more sources
Journal of Infection and Public Health, 2018 Background: Rifampicin (RIF) plays a pivotal role in the treatment of tuberculosis due to its bactericidal effects. Because the action of RIF is on rpoB gene encoding RNA polymerase β subunit, 95% of RIF resistant mutations are present in rpoB gene.
Zaw Lin
exaly +3 more sources
Nested PCR to optimize rpoB metabarcoding for low-concentration and host-associated bacterial DNA [PDF]
Microbiology SpectrumHousekeeping genes have proven to be effective taxonomic markers for characterizing bacterial microbiota in short-read amplicon metabarcoding studies. A region of the rpoB gene has been shown to minimize Operational Taxonomic Unit (OTU) overestimation ...
Laëtitia Leclerc +9 more
doaj +2 more sources
Association of D516V, H526Y, and S531L rpoB gene polymorphisms and risk factors with rifampicin resistance in Mycobacterium tuberculosis isolates from pulmonary TB patients in Northwest Amhara, Ethiopia: cross-sectional study. [PDF]
BMC Infect DisGetachew K, Seid A, Berhane N.
europepmc +2 more sources
The evaluation of shotgun sequencing and rpoB metabarcoding for taxonomic profiling of bacterial communities [PDF]
BMC MicrobiologyBackground The importance of microbial community profiling has been increasingly recognized in biological and environmental research. While metabarcoding has been widely used for such analysis by targeting specific DNA sequences as markers, shotgun ...
Karine Durand +2 more
doaj +2 more sources
Journal of Pure and Applied Microbiology, 2021 Resistance to antimycobacterial agents consistently remains a major obstacle to end TB in India. Geographical prevalence data regarding drug-resistant evolutionary genetics of M. tuberculosis (MTB) remains sparse in India. Our objective was to determine
Neetha S Murthy +8 more
doaj +1 more source
Rifampicin resistance conferring mutations among Mycobacterium tuberculosis strains in Rwanda
International Journal of Mycobacteriology, 2023 Background: The World Health Organization-endorsed phenotypic and genotypic drug-susceptibility testing (gDST/pDST) assays for the detection of rifampicin-resistant (RR) tuberculosis (TB), may miss some clinically relevant rpoB mutants, including ...
Isabel Cuella-Martin +11 more
doaj +1 more source
International Journal of Mycobacteriology, 2020 Background: Rifampicin (RIF) resistance in Mycobacterium tuberculosis is frequently caused by mutations in the rpoB gene. These mutations are associated with a fitness cost, which can be overcome by compensatory mutations in other genes, among which rpoC
Ana Paula Vargas +6 more
doaj +1 more source
İstanbul Tıp Fakültesi Dergisi, 2022 Objective: The aim of this study was to evaluate the GenoType®MTBDRplus test for detection of rifampicin (RIF) resistance in MDR Mycobacterium tuberculosis complex strains.
Esra Yıldırım Servi, Meltem Uzun
doaj +1 more source