Role of S-palmitoylation in digestive system diseases [PDF]
Cell Death DiscoveryDigestive system diseases, including liver diseases, gastrointestinal cancers, and inflammatory bowel diseases, pose major health challenges worldwide.
Hanqing Li +4 more
doaj +4 more sources
Advances in targeting protein S-palmitoylation in tumor immunity and therapy [PDF]
Frontiers in OncologyS-palmitoylation is a reversible and dynamic post-translational modification of proteins. A palmitoyl group is covalently attached to a cysteine residue of the protein by a thioester link.
Miaomiao Han +13 more
doaj +5 more sources
S-palmitoylation-related genes in Crohn's disease: Bioinformatic identification and validation [PDF]
Biomolecules & BiomedicineCrohn's disease (CD) is a complex chronic inflammatory bowel disorder characterized by the absence of reliable biomarkers and effective targeted treatments.
Yuyan Zhou, Yuxuan Zhao
doaj +6 more sources
S-palmitoylation of MAP kinase is essential for fungal virulence [PDF]
mBioS-palmitoylation is an important reversible protein post-translational modification in organisms. However, its role in fungi is uncertain. Here, we found the treatment of the rice false fungus Ustilaginoidea virens with S-palmitoylation inhibitor 2 BP ...
Yuhang Duan +18 more
doaj +5 more sources
The Unconventional Role of ABHD17A in Increasing the S-Palmitoylation and Antiviral Activity of IFITM1 by Downregulating ABHD16A [PDF]
BiomoleculesThe broad-spectrum antiviral functions of interferon-inducible transmembrane 1 (IFITM1) rely on S-palmitoylation post-translational modification.
Xuemeng Shi +11 more
doaj +3 more sources
Recent advances in S-palmitoylation and its emerging roles in human diseases [PDF]
Journal of Hematology & OncologyS-palmitoylation, one reversible post-translational modification (PTM) involving the binding of palmitate to proteins, influences protein stability, localization and interactions.
Juanjuan Shang +2 more
doaj +3 more sources
Protein S-palmitoylation modification: implications in tumor and tumor immune microenvironment [PDF]
Frontiers in ImmunologyProtein S-palmitoylation is a reversible post-translational lipid modification that involves the addition of a 16-carbon palmitoyl group to a protein cysteine residue via a thioester linkage.
Yijiao Chen, Yongsheng Li, Lei Wu
doaj +3 more sources
Protein S-Palmitoylation as Potential Therapeutic Target for Dermatoses [PDF]
BiomoleculesProtein S-palmitoylation is a pivotal yet poorly integrated research field in dermatology. This reversible post-translational lipid modification primarily occurs on cysteine residues and is principally catalyzed by zinc finger and Asp-His-His-Cys DHHC ...
Yanhai Feng +9 more
doaj +3 more sources
S-palmitoylation modulates ATG2-dependent non-vesicular lipid transport during starvation-induced autophagy [PDF]
The EMBO JournalLipid transfer proteins mediate the non-vesicular transport of lipids at membrane contact sites to regulate the lipid composition of organelle membranes. Despite significant recent advances in our understanding of the structural basis for lipid transfer,
Wenhui Zheng +9 more
doaj +3 more sources
Zinc finger DHHC-type palmitoyltransferase 13-mediated S-palmitoylation of GNA13 from Sertoli cell-derived extracellular vesicles inhibits autophagy in spermatogonial stem cells [PDF]
Cell Communication and SignalingExtracellular vesicles (EVs) originating from testicular somatic cells act as pivotal intermediaries in cell signaling crosstalk between spermatogenic cells and the testicular microenvironment.
Heran Cao +9 more
doaj +3 more sources