Results 11 to 20 of about 22,830,963 (211)

PRDX6: A protein bridging S-palmitoylation and diabetic neuropathy [PDF]

Frontiers in Endocrinology, 2022
Diabetic neuropathy is regarded as one of the most debilitating outcomes of diabetes. It can affect both the peripheral and central nervous systems, leading to pain, decreased motility, cognitive decline, and dementia.
Yan Cao, Wantao Wang, Xiaorong Zhan, Yitong Zhang   +3 more
doaj   +4 more sources

Topology-driven discovery of transmembrane protein S-palmitoylation. [PDF]

J Biol Chem
Protein S-palmitoylation is a reversible lipophilic posttranslational modification regulating diverse signaling pathways. Within transmembrane proteins (TMPs), S-palmitoylation is implicated in conditions from inflammatory disorders to respiratory viral ...
Forrester MT, Egol JR, Ozbay S, Waddell FD, Singh R, Tata PR.   +5 more
europepmc   +4 more sources

ZDHHC20 mediated S-palmitoylation of fatty acid synthase (FASN) promotes hepatocarcinogenesis. [PDF]

Mol Cancer
Protein palmitoylation is a reversible fatty acyl modification that undertakes important functions in multiple physiological processes. Dysregulated palmitoylations are frequently associated with the formation of cancer.
Mo Y, Han Y, Chen Y, Fu C, Li Q, Liu Z, Xiao M, Xu B.   +7 more
europepmc   +5 more sources

Targeted degradation of zDHHC-PATs decreases substrate S-palmitoylation. [PDF]

PLoS One
Reversible S-palmitoylation of protein cysteines, catalysed by a family of integral membrane zDHHC-motif containing palmitoyl acyl transferases (zDHHC-PATs), controls the localisation, activity, and interactions of numerous integral and peripheral ...
Bai M, Gallen E, Memarzadeh S, Howie J, Gao X, Kuo CS, Brown E, Swingler S, Wilson SJ, Shattock MJ, France DJ, Fuller W.   +11 more
europepmc   +5 more sources

ZDHHC5-mediated S-palmitoylation of FAK promotes its membrane localization and epithelial-mesenchymal transition in glioma [PDF]

Cell Communication and Signaling
Background Abnormal activation of FAK is associated with tumor development and metastasis. Through interactions with other intracellular signalling molecules, FAK influences cytoskeletal remodelling, modulation of adhesion signalling, and activation of ...
Yang Wang, Na Shen, Yang Yang, Yuan Xia, Wenhao Zhang, Yu Lu, Zhicheng Wang, Ze Yang, Zhangjie Wang   +8 more
doaj   +3 more sources

Inhibiting S-palmitoylation arrests metastasis by relocating Rap2b from plasma membrane in colorectal cancer [PDF]

Cell Death and Disease
Rap2b, a proto-oncogene upregulated in colorectal cancer (CRC), undergoes protein S-palmitoylation at specific C-terminus sites (C176/C177). These palmitoylation sites are crucial for Rap2b localization on the plasma membrane (PM), as mutation of C176 or
Jiangli Zhu, Xize Cao, Zhenshuai Chen, Birou Lai, Lingling Xi, Jinghang Zhang, Shaohui Zhu, Shiqian Qi, Yinming Liang, Fei Cao, Binhui Zhou, Yu Song, Sheng Jiang, Tianyu Wang, Xiaohong Kang, Eryan Kong   +15 more
doaj   +3 more sources

Protein S-palmitoylation enhances profibrotic signaling in response to cadmium. [PDF]

Toxicol Appl Pharmacol
Cadmium (Cd) is a naturally occurring, toxic environmental metal found in foods. Humans do not have an efficient mechanism for Cd elimination; thus, Cd burden in humans increases with age. Cell and mouse studies show that Cd burden from low environmental
Lee CM, Jarrell ZR, Lee HY, Singer G, Tran VT, Orr M, Jones DP, Go YM.   +7 more
europepmc   +4 more sources

ROS-dependent S-palmitoylation activates cleaved and intact gasdermin D. [PDF]

Nature
Gasdermin D (GSDMD) is the common effector for cytokine secretion and pyroptosis downstream of inflammasome activation and was previously shown to form large transmembrane pores after cleavage by inflammatory caspases to generate the GSDMD N-terminal domain (GSDMD-NT)1-10.
Du G, Healy LB, David L, Walker C, El-Baba TJ, Lutomski CA, Goh B, Gu B, Pi X, Devant P, Fontana P, Dong Y, Ma X, Miao R, Balasubramanian A, Puthenveetil R, Banerjee A, Luo HR, Kagan JC, Oh SF, Robinson CV, Lieberman J, Wu H.   +22 more
europepmc   +4 more sources

The role of s-palmitoylation in neurological diseases: implication for zDHHC family. [PDF]

Front Pharmacol, 2023
S-palmitoylation is a reversible posttranslational modification, and the palmitoylation reaction in human-derived cells is mediated by the zDHHC family, which is composed of S-acyltransferase enzymes that possess the DHHC (Asp-His-His-Cys) structural ...
Liao D, Huang Y, Liu D, Zhang H, Shi X, Li X, Luo P.   +6 more
europepmc   +2 more sources

Temporal and protein-specific S-palmitoylation supports synaptic and neural network plasticity [PDF]

Cellular and Molecular Life Sciences
Background Synaptic plasticity, a fundamental process underlying learning and memory, depends on activity-driven changes in neural connectivity. S-palmitoylation, a reversible post-translational lipid modification, modulates synaptic protein function by ...
Agata Pytyś, Rabia Ijaz, Anna Buszka, Jacek Miłek, Izabela Figiel, Patrycja Wardaszka-Pianka, Matylda Roszkowska, Natalia Mierzwa, Adam Wojtas, Eli Kerstein, Remigiusz Serwa, Katarzyna Kalita, Rhonda Dzakpasu, Magdalena Dziembowska, Jakub Włodarczyk, Tomasz Wójtowicz   +15 more
doaj   +2 more sources