Results 21 to 30 of about 22,830,963 (211)

zDHHC-Mediated S-Palmitoylation in Skin Health and Its Targeting as a Treatment Perspective. [PDF]

Int J Mol Sci
S-acylation, which includes S-palmitoylation, is the only known reversible lipid-based post-translational protein modification. S-palmitoylation is mediated by palmitoyl acyltransferases (PATs), a family of 23 enzymes commonly referred to as zDHHCs ...
Abdulrahman FA, Benford KA, Lin GT, Maroun AJ, Sammons C, Shirzad DN, Tsai H, Van Brunt VL, Jones Z, Marquez JE, Ratkus EC, Shehadeh AK, Abasto Valle H, Fejzo D, Gilbert AE, McWee CA, Underwood LF, Indico E, Rork BB, Nanjundan M.   +19 more
europepmc   +2 more sources

S-Palmitoylation of Synaptic Proteins in Neuronal Plasticity in Normal and Pathological Brains [PDF]

Cells, 2023
Protein lipidation is a common post-translational modification of proteins that plays an important role in human physiology and pathology. One form of protein lipidation, S-palmitoylation, involves the addition of a 16-carbon fatty acid (palmitate) onto ...
Anna Buszka, Agata Pytyś, Domnic Colvin, Jakub Włodarczyk, Tomasz Wójtowicz   +4 more
doaj   +2 more sources

S-palmitoylation of MTDH regulates ferroptosis resistance in breast cancer cell. [PDF]

J Lipid Res
S-palmitoylation is a dynamic and reversible post-translational modification that plays crucial roles in cancer progression. Here, we found that the oncogene of metadherin (MTDH) modulates lipid metabolism and ferroptosis by its S-palmitoylation.
Pei S, Wang W, Feng T, Wang Q, Wang Y, Liu HX, Liang X, Piao HL.   +7 more
europepmc   +2 more sources

Protein S-palmitoylation in immunity [PDF]

Open Biology, 2021
S-palmitoylation is a reversible posttranslational lipid modification of proteins. It controls protein activity, stability, trafficking and protein–protein interactions. Recent global profiling of immune cells and targeted analysis have identified many S-
Tandrila Das, Jacob S. Yount, Howard C. Hang   +2 more
doaj   +3 more sources

Lipid overload meets S-palmitoylation: a metabolic signalling nexus driving cardiovascular and heart disease. [PDF]

Cell Commun Signal
S-palmitoylation has emerged as a critical integrator of lipid overload and cardiovascular dysfunction. Disordered lipid metabolism inundates endothelial cells, vascular smooth muscle cells and macrophages with triglyceriderich lipoproteins, oxidized LDL
Zhang J, Wu S, Xu Y, Zhang L, Cong C, Zhang M, Jiang Y, Liu Y.   +7 more
europepmc   +2 more sources

ZDHHC20-mediated S-palmitoylation of YTHDF3 stabilizes MYC mRNA to promote pancreatic cancer progression. [PDF]

Nat Commun
Post-translational modifications of proteins in malignant transformation and tumor maintenance of pancreatic ductal adenocarcinoma (PDAC) in the context of KRAS signaling remain poorly understood. Here, we use the KPC mouse model to examine the effect of
Zhang H, Sun Y, Wang Z, Huang X, Tang L, Jiang K, Jin X.   +6 more
europepmc   +2 more sources

Transcriptome associated with single-cell analysis reveal the role of S-palmitoylation in coronary artery disease. [PDF]

Sci Rep
Coronary artery disease (CAD), a widespread cardiovascular ailment, exhibits a strong association with palmitoylation. This research aimed to elucidate the role of S-palmitoylation in CAD through bioinformatics, providing novel perspectives on the ...
Xing Y, Lin X.
europepmc   +2 more sources

ZDHHC21-driven S-palmitoylation of Themis regulates the function of T cells and maintains homeostatic balance. [PDF]

Cell Commun Signal
T-cell activation [10]. Nevertheless, the function of S-palmitoylation in regulating the signals of T cell activation remains to be fully illustrated.
Meng C, Dai X, Sun L, Huang D, Xu X, Cheng Y, Zhang W.   +6 more
europepmc   +2 more sources

S-palmitoylation: a novel insight in the development and immunotherapy of oral squamous cell carcinoma. [PDF]

J Cancer
S-palmitoylation (hereinafter referred to as palmitoylation) is a reversible lipid modification that has recently received considerable attention in cancer research. Despite its known association with tumour progression and treatment response, it remains
Yuan XT, Wang JR, Yang Y, Ren JG.
europepmc   +2 more sources

Protein S-palmitoylation regulates the virulence of plant pathogenic fungi [PDF]

mBio
Protein S-palmitoylation, a universal posttranslational modification catalyzed by a specific group of palmitoyltransferases, plays crucial roles in diverse biological processes across organisms by modulating protein functions.
Mengmeng Guo, Leeza Tariq, Fengming Song
doaj   +2 more sources