ZDHHC12-mediated claudin-3 S-palmitoylation determines ovarian cancer progression
Acta Pharmaceutica Sinica B, 2020 The membrane protein claudin-3 (CLDN3) is critical for the formation and maintenance of tight junction and its high expression has been implicated in dictating malignant progression in various cancers.
Meng Yuan +10 more
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Inhibition of zDHHC7-driven protein S-palmitoylation prevents cognitive deficits in an experimental model of Alzheimer's disease. [PDF]
Proc Natl Acad Sci U S ASignificance S-palmitoylation is a protein post-translational modification regulating protein localization and catalyzed by zinc finger DHHC domain containing (zDHHC) S-acyltransferases.
Natale F +8 more
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ZDHHC7-mediated S-palmitoylation of ATG16L1 facilitates LC3 lipidation and autophagosome formation. [PDF]
AutophagyMacroautophagy/autophagy is a fundamental cellular catabolic process that delivers cytoplasmic components into double-membrane vesicles called autophagosomes, which then fuse with lysosomes and their contents are degraded.
Wei F +13 more
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Research progress on S-palmitoylation modification mediated by the ZDHHC family in glioblastoma. [PDF]
Front Cell Dev BiolS-Palmitoylation has been widely noticed and studied in a variety of diseases. Increasing evidence suggests that S-palmitoylation modification also plays a key role in Glioblastoma (GBM).
Tang B +7 more
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SMAD2 S-palmitoylation promotes its linker region phosphorylation and T<sub>H</sub>17 cell differentiation in a mouse model of multiple sclerosis. [PDF]
Sci SignalThe transcriptional regulators SMAD2 and SMAD3 share the same primary signaling pathway in response to the cytokine TGF-β. However, whereas SMAD2 stimulates the differentiation of naive CD4+ T cells into proinflammatory T helper 17 (TH17) cells, SMAD3 ...
Zhang M +9 more
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zDHHC3-mediated S-palmitoylation of SLC9A2 regulates apoptosis in kidney clear cell carcinoma. [PDF]
J Cancer Res Clin OncolKidney clear cell carcinoma (KIRC) has a poor prognosis, high morbidity and mortality rates, and high invasion and metastasis rate, and effective therapeutic targets are lacking.
Zhang X, Hou J, Zhou G, Wang H, Wu Z.
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Protocol for a semi-quantitative approach to identify protein S-palmitoylation in cultured cells by acyl biotin exchange assay. [PDF]
STAR ProtocSummary Palmitoylation is a post-translational lipid modification in which palmitic acid is conjugated predominantly to cysteine residues of target proteins, allowing them to tether to cell membranes.
Leishman S, Aljadeed NM, Anand PK.
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The long noncoding RNA lncZBTB10 facilitates AR function via S-palmitoylation to promote prostate cancer progression and abiraterone resistance. [PDF]
Br J CancerLin SC +8 more
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PPT1 regulation of HSP90α depalmitoylation participates in the pathogenesis of hyperandrogenism
iScience, 2023 Summary: Ovarian granulosa cells (GCs) in the follicle are the important mediator of steroidogenesis and foster oocyte maturation. Evidences suggested that the function of GCs could be regulated by S-palmitoylation.
Tongmin Xue +13 more
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Protein S-palmitoylation in cellular differentiation [PDF]
Biochemical Society Transactions, 2017 Reversible protein S-palmitoylation confers spatiotemporal control of protein function by modulating protein stability, trafficking and activity, as well as protein–protein and membrane–protein associations. Enabled by technological advances, global studies revealed S-palmitoylation to be an important and pervasive posttranslational modification in ...
Zhang, Mingzi M., Hang, Howard C.
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