Results 41 to 50 of about 22,830,963 (211)
S-palmitoylation and the regulation of NCX1 [PDF]
Channels, 2015 Investigations into reversible cysteine acylation (S-palmitoylation) have enjoyed a renaissance recently, thanks to numerous techniques that have improved the sensitivity of detection above the tra...
Fuller, William +2 more
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S-Palmitoylation of Tyrosinase at Cysteine500 Regulates Melanogenesis
Journal of Investigative Dermatology, 2023 Palmitoylation is a lipid modification involving the attachment of palmitic acid to a cysteine residue, thereby affecting protein function. We investigated the effect of palmitoylation of tyrosinase, the rate-limiting enzyme in melanin synthesis, using a human three-dimensional skin model system and melanocyte culture.
Yoko Niki +14 more
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S-palmitoylation determines TMEM55B-dependent positioning of lysosomes
Journal of Cell Science, 2021 ABSTRACT The spatiotemporal cellular distribution of lysosomes depends on active transport mainly driven by microtubule motors such as kinesins and dynein. Different protein complexes attach these molecular motors to their vesicular cargo. TMEM55B (also known as PIP4P1), as an integral lysosomal membrane protein, is a component of such a
Sönke Rudnik +3 more
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Extensive molecular tinkering in the evolution of the membrane attachment mode of the Rheb GTPase [PDF]
, 2018 Rheb is a conserved and widespread Ras-like GTPase involved in cell growth regulation mediated by the (m)TORC1 kinase complex and implicated in tumourigenesis in humans. Rheb function depends on its association with membranes via prenylated C-terminus, a
Burger Gertraud +16 more
core +6 more sources
DHHC9-mediated GLUT1 S-palmitoylation promotes glioblastoma glycolysis and tumorigenesis [PDF]
Nature Communications, 2021 AbstractGlucose transporter GLUT1 is a transmembrane protein responsible for the uptake of glucose into the cells of many tissues through facilitative diffusion. Plasma membrane (PM) localization is essential for glucose uptake by GLUT1. However, the mechanism underlying GLUT1 PM localization remains enigmatic.
Zhenxing Zhang +10 more
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Role of S-palmitoylation on IFITM5 for the interaction with FKBP11 in osteoblast cells. [PDF]
PLoS ONE, 2013 Recently, one of the interferon-induced transmembrane (IFITM) family proteins, IFITM3, has become an important target for the activity against influenza A (H1N1) virus infection.
Takashi Tsukamoto +6 more
doaj +1 more source
Hepatology, EarlyView., 2022 KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou +15 more
wiley +1 more source
eLife, 2022 Protein S-palmitoylation is a reversible post-translational lipid modification that plays a critical role in neuronal development and plasticity, while dysregulated S-palmitoylation underlies a number of severe neurological disorders.
Angela R Wild +7 more
doaj +1 more source
Frontiers in Physiology, 2023 The reversible lipid modification protein S-palmitoylation can dynamically modify the localization, diffusion, function, conformation and physical interactions of substrate proteins.
Angela R. Wild +6 more
doaj +1 more source
ZDHHC7-mediated S-palmitoylation of Scribble regulates cell polarity [PDF]
Nature Chemical Biology, 2016 Scribble (SCRIB) is a tumor-suppressor protein, playing critical roles in establishing and maintaining epithelial cell polarity. SCRIB is frequently amplified in human cancers but does not localize properly to cell-cell junctions, suggesting that mislocalization of SCRIB disrupts its tumor-suppressive activities.
Baoen Chen +6 more
openaire +3 more sources