Results 51 to 60 of about 22,830,963 (211)

Dynamic but discordant alterations in zDHHC5 expression and palmitoylation of its substrates in cardiac pathologies

Frontiers in Physiology, 2022
S-palmitoylation is an essential lipid modification catalysed by zDHHC-palmitoyl acyltransferases that regulates the localisation and activity of substrates in every class of protein and tissue investigated to date.
Alice Main, Andri Boguslavskyi, Jacqueline Howie, Chien-Wen Kuo, Aileen Rankin, Francis L. Burton, Godfrey L. Smith, Roger Hajjar, George S. Baillie, Kenneth S. Campbell, Michael J. Shattock, William Fuller   +11 more
doaj   +1 more source

Identification of Giardia lamblia DHHC Proteins and the Role of Protein S-palmitoylation in the Encystation Process [PDF]

, 2014
Protein S-palmitoylation, a hydrophobic post-translational modification, is performed by protein acyltransferases that have a common DHHC Cys-rich domain (DHHC proteins), and provides a regulatory switch for protein membrane association. In this work, we
A Criscuolo, A Hiltpold, A Krogh, AB Hehl, AF Roth, AF Roth, AI Magee, Andrea S. Rópolo, B Eisenhaber, BC Jennings, BJ Davids, BJ Davids, BR Martin, BT Emmer, C Aicart-Ramos, C Aurrecoechea, C Faso, C Notredame, C Salaun, Cecilia V. Vranych, CH Sun, CH Sun, CH Wang, D Lloyd, DA Mitchell, DA Mitchell, DB Keister, DJ Bartels, DS Reiner, DS Reiner, EG Politis, F Abascal, FD Gillin, G DeJesus, GE Tusnady, GE Tusnady, HD Lujan, HD Lujan, HG Elmendorf, HG Morrison, I Letunic, I Letunic, I Slavin, J Greaves, J Greaves, J Greaves, J Pei, J Ren, J Schindelin, J Schultz, J Wan, J Yee, JA Duncan, JE Smotrys, JO Ebinu, JR Beck, JT Dunphy, K Frenal, KB Nicholas, KJ Livak, L Morf, LH Su, M Anisimova, M Fukata, M Punta, M Saric, María C. Merino, María C. Touz, MC Touz, MC Touz, MC Touz, MC Touz, MD Resh, ME Linder, ME Linder, MG De Napoli, ML Jones, ML Jones, MM Corvi, MM Zhang, MR Rivero, MS Brown, N Gottig, Nahuel Zamponi, O Batistic, O Rocks, P Papanastasiou, PG Carranza, R Tsutsumi, RD Adam, RD Finn, S Guindon, S Lobo, S Sonda, S Stoven, SE Boucher, SF Chuang, SL Planey, SM Singer, SR Birkeland, Steven M. Singer, T Hoppe, T Lauwaet, TE Nash, TE Nash, TN Petersen, TS Worgall, WF Leong, Y Fukata, Y He, Y Huang, Y Ohno, Y Webb, YC Huang, YJ Pan   +114 more
core   +3 more sources

Cytoplasmic tail determines the membrane trafficking and localization of SARS-CoV-2 spike protein

Frontiers in Molecular Biosciences, 2022
The spike (S) glycoprotein of SARS-CoV-2 mediates viral entry through associating with ACE2 on host cells. Intracellular trafficking and palmitoylation of S protein are required for its function.
Qinlin Li, Qinlin Li, Qinlin Li, Yihan Liu, Yihan Liu, Leiliang Zhang, Leiliang Zhang, Leiliang Zhang   +7 more
doaj   +1 more source

Maleimide scavenging enhances determination of protein S-palmitoylation state in acyl-exchange methods. [PDF]

, 2017
S-palmitoylation (S-acylation) is an emerging dynamic post-translational modification of cysteine residues within proteins.Current assays for protein S-palmitoylation involve either in vivo labelling or chemical cleavage of S-palmitoyl groupsto reveal a ...
Fuller, William, Hemsley, Piers A., Hurst, Charlotte H., Plain, Fiona, Turnbull, Dionne   +4 more
core   +3 more sources

Chemoproteomics reveals Toll-like receptor fatty acylation [PDF]

, 2014
Partial funding for Open Access provided by The Ohio State University Open Access Fund.Background: Palmitoylation is a 16-carbon lipid post-translational modification that increases protein hydrophobicity.
A Bafica, AF Roth, AI Su, AI Su, BA Merrick, Balyn W Zaro, BH Zheng, BR Martin, BR Martin, C Aicart-Ramos, C Ivaldi, C Salaun, C Wu, CB Lopez, CB Lopez, CT Tom, D Davda, D Rotin, E Latz, E Lorenz, F Sandor, G Charron, G Charron, GJ Freeman, H Kato, HC Hang, Howard C Hang, J Charollais, J Greaves, J Greaves, J Ren, Jacob S Yount, James L Chen, JC Hach, JL Hernandez, Joanne Turner, Jocelyn C Hach, JP Wilson, JS Yount, JS Yount, JS Yount, JS Yount, JS Yount, JS Yount, JS Yount, JS Yount, KJ Brandt, L Dowal, Larry S Schlesinger, M Fukata, M Muzio, M Scheffner, M Triantafilou, M Yamamoto, MA Imro, Matthew R Pratt, ME Linder, Murugesan VS Rajaram, Nicholas M Chesarino, NT Thuong, O Takeuchi, P Hollsberg, P Mill, R Barbalat, R Kang, R Tsutsumi, RM Steinman, RN Hannoush, S Blaskovic, S Borrello, S Kupzig, SC Henry, T Kawai, T Kawai, TR Hawn, Y Bulut, Y Fukata, Y Li, Y Webb, YY Yang, Z Jiang   +80 more
core   +2 more sources

Akt Is S-Palmitoylated: A New Layer of Regulation for Akt [PDF]

Frontiers in Cell and Developmental Biology, 2021
The protein kinase Akt/PKB participates in a great variety of processes, including translation, cell proliferation and survival, as well as malignant transformation and viral infection. In the last few years, novel Akt posttranslational modifications have been found.
Matías Blaustein, Matías Blaustein, Matías Blaustein, Estefanía Piegari, Estefanía Piegari, Camila Martínez Calejman, Antonella Vila, Antonella Vila, Antonella Vila, Analía Amante, Analía Amante, Analía Amante, María Victoria Manese, Ari Zeida, Laurence Abrami, Mariela Veggetti, Mariela Veggetti, David A. Guertin, David A. Guertin, David A. Guertin, F. Gisou van der Goot, María Martha Corvi, Alejandro Colman-Lerner, Alejandro Colman-Lerner   +23 more
openaire   +5 more sources

zDHHC20-driven S-palmitoylation of CD80 is required for its costimulatory function. [PDF]

Acta Pharmacol Sin
Lu B, Sun YY, Chen BY, Yang B, He QJ, Li J, Cao J.   +6 more
europepmc   +2 more sources

Rif1 S-acylation mediates DNA double-strand break repair at the inner nuclear membrane [PDF]

, 2019
Rif1 is involved in telomere homeostasis, DNA replication timing, and DNA double-strand break (DSB) repair pathway choice from yeast to human. The molecular mechanisms that enable Rif1 to fulfill its diverse roles remain to be determined.
A Davé, A Kalousi, A Seeber, A Taddei, AF Roth, B Chen, B MacLean, BR Martin, C Escribano-Diaz, C Horigome, C Lemaître, C Zierhut, CA Fox, CA Schneider, D Cornacchia, DE Gottschling, G Kyrion, G Xu, GA Fontana, H Dev, H Ghezraoui, H Zhang, J Schindelin, J Tomida, J Wan, JA Vizcaíno, JE DiCarlo, JK Moore, JM Peace, JR Chapman, K Bystricky, K Moriyama, KKY Lam, L Feng, L Hafner, L Hafner, LH Chamberlain, M Blanc, M Deng, M Di Virgilio, M Hayano, M Kalocsay, M Zimmermann, MD Resh, MS Longtine, N Cao, P Oza, R Foti, R Gupta, R Kumar, RC Alver, S Mattarocci, S Mattarocci, S Mattarocci, S Nagai, S Park, S Stuckey, S Yamazaki, SE Lee, SI Hiraga, SM Noordermeer, T Lanyon-Hogg, T Shi, U Rass, V Boersma, Y Ji, Y Kanoh, Y Ohno, Y Zhang, Z Mirman   +69 more
core   +1 more source

Protein palmitoylation plays an important role in Trichomonas vaginalis adherence [PDF]

, 2018
The flagellated protozoan parasite Trichomonas vaginalis is the etiologic agent of trichomoniasis, the most common non-viral sexually transmitted infection worldwide.
Corvi, Maria Martha, de Miguel, Natalia, Johnson, Patricia J, Metz, Sebastián Darío, Nievas, Yésica Romina, Vashisht, Ajay A., Wohlschlegel, James A.   +6 more
core   +2 more sources

Steroid hormone rapid signaling: The pivotal role of S-Palmitoylation [PDF]

IUBMB Life, 2006
Nuclear receptors (NRs) comprise a large family of proteins essential to manipulate various aspects of human biology. The class III of the NR family includes steroid hormone receptors (SHRs) involved in embryonic development, maintenance of differentiated cellular phenotypes, metabolism, and cell death.
MARINO, Maria, ASCENZI, Paolo
openaire   +4 more sources