Results 191 to 200 of about 37,201 (219)
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S100 proteins in rheumatic diseases
Nature Reviews Rheumatology, 2018Rheumatic diseases are characterized by sterile inflammation that causes severe long-term damage to various organ systems. A growing body of evidence supports a pivotal role for the pro-inflammatory calcium-binding S100 family of proteins in the pathogenesis of rheumatic diseases.
Judith, Austermann +2 more
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S100 protein and down syndrome
BioEssays, 1990AbstractS100 protein is a low molecular weight calcium‐binding protein widely distributed in the central nervous system of vertebrates. Recent evidence suggests that S100 protein may play a role in the regulation of glial proliferation and neuronal differentiation. The gene for S100 protein has been mapped to the 21q22 region, a chromosomal locus whose
A, Marks, R, Allore
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Intrinsic disorder in S100 proteins
Molecular BioSystems, 2011Abstract Although the members of the largest subfamily of the EF-hand proteins, S100 proteins, are evolutionarily young, their functional diversity is extremely broad, partly due to their ability to adapt to various targets. This feature is a hallmark of intrinsically disordered proteins (IDPs), but none of the S100 proteins are ...
Sergei E, Permyakov +5 more
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Bovine Brain S100 Proteins: Separation and Characterization of a New S100 Protein Species
Journal of Neurochemistry, 1983Abstract: Three S100 protein species (S100a, S100b, S100a′) have been purified from bovine brain using a modification of standard preparative methods. A higher yield for each protein was obtained at the last separation step. Characterization by urea/sodium dodecyl sulfate/polyacrylamide gel electrophoresis, UV absorption spectra, and fluorescence ...
J, Baudier, P, Mandel, D, Gérard
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1996
Abstract Members of the 5100 Ca2•-binding protein family are typically small, acidic proteins containing two Ca2•-binding sites. It has been suggested, that they are associated with cell cycle progression, differentiation, metabolism, and the generation of neoplastic cells. Each member of the 5100 protein family shows a unique spatial
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Abstract Members of the 5100 Ca2•-binding protein family are typically small, acidic proteins containing two Ca2•-binding sites. It has been suggested, that they are associated with cell cycle progression, differentiation, metabolism, and the generation of neoplastic cells. Each member of the 5100 protein family shows a unique spatial
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S100 Proteins in Autoinflammation
2019Among the putative markers for autoinflammatory diseases, studies on phagocyte-derived S100 proteins (S100A8/A9, S100A12: calgranulins) are the most advanced to date. Translational studies have suggested an important role for these danger-associated molecular pattern (DAMP) molecules as robust inflammation biomarkers.
Dirk Holzinger +2 more
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S100 proteins structure functions and pathology
Frontiers in Bioscience, 2002S100 proteins regulate intracellular processes such as cell growth and motility, cell cycle regulation, transcription and differentiation. Twenty members have been identified so far, and altogether, S100 proteins represent the largest subgroup in the EF-hand Ca2+ -binding protein family. A unique feature of these proteins is that individual members are
Claus W, Heizmann +2 more
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2017
Con l’eccezione della S100G che è una proteina Ca2+-modulatrice che agisce quale tampone del Ca2+ citosolico, tutte le altre proteine S100 sono sensori del Ca2+ coinvolte nella regolazione della proliferazione, il differenziamento e la motilità cellulari, lo sviluppo e la crescita tumorali e le metastasi, l’omeostasi del Ca2+, l’apoptosi, l ...
Rosario Donato +2 more
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Con l’eccezione della S100G che è una proteina Ca2+-modulatrice che agisce quale tampone del Ca2+ citosolico, tutte le altre proteine S100 sono sensori del Ca2+ coinvolte nella regolazione della proliferazione, il differenziamento e la motilità cellulari, lo sviluppo e la crescita tumorali e le metastasi, l’omeostasi del Ca2+, l’apoptosi, l ...
Rosario Donato +2 more
openaire +1 more source