Results 31 to 40 of about 2,346 (204)

Effect of safranal, a constituent of saffron, on olanzapine (an atypical antipsychotic) induced metabolic disorders in rat [PDF]

Iranian Journal of Basic Medical Sciences, 2019
Objective(s): Olanzapine, an atypical antipsychotic, causes weight gain and metabolic disorders in humans. Safranal, one of the active components of Crocus sativus (saffron), has been shown to have anti-obesity, lipid and blood pressure lowering and anti-
Sara Malekzadeh, Mahmoud Reza Heidari, Marjan Razavi, Maryam Rameshrad, Hossein Hosseinzadeh   +4 more
doaj   +1 more source

Safrana l Prevents Prostate Cancer Recurrence by Blocking the Re-activation of Quiescent Cancer Cells via Downregulation of S-Phase Kinase-Associated Protein 2

Frontiers in Cell and Developmental Biology, 2020
The re-proliferation of quiescent cancer cells is considered to be the primary contributor to prostate cancer (Pca) recurrence and progression. In this study, we investigated the inhibitory effect of safranal, a monoterpene aldehyde isolated from Crocus ...
Xue Jiang, Yang Li, Ji-ling Feng, Ji-ling Feng, Wan Najbah Nik Nabil, Wan Najbah Nik Nabil, Rong Wu, Yue Lu, Hua Liu, Zhi-chao Xi, Hong-xi Xu, Hong-xi Xu   +11 more
doaj   +1 more source

Interactions of Apigenin and Safranal with the 5HT1A and 5HT2A Receptors and Behavioral Effects in Depression and Anxiety: A Molecular Docking, Lipid-Mediated Molecular Dynamics, and In Vivo Analysis

Molecules, 2022
Background: The current study utilizes in silico molecular docking/molecular dynamics to evaluate the binding affinity of apigenin and safranal with 5HT1AR/5HT2AR, followed by assessment of in vivo effects of these compounds on depressive and anxious ...
Faiq Amin, Mahmoud A. A. Ibrahim, Syed Rizwan-ul-Hasan, Saima Khaliq, Gamal A. Gabr, Muhammad, Asra Khan, Peter A. Sidhom, Prashant Tikmani, Ahmed M. Shawky, Saara Ahmad, Syed Hani Abidi   +11 more
doaj   +1 more source

The Effect of Safranal on Th1/Th2 Cytokine Balance [PDF]

Iranian Journal of Immunology, 2016
Background: Several biological and medical benefits of Saffron, Crocus sativus (Iridaceae), have been demonstrated. However, mechanisms of actions for purified constituents are greatly unknown.
Reza Feyzi, Mohammad Hossein Boskabady, Seyedeh Masoumeh Seyed hosseini Tamijani, Houshang Rafatpanah, Seyed Abdolrahim Rezaei   +4 more
doaj  

The Research of Optimal Conditions for Safranal Extraction From Saffron Flower [PDF]

, 2021
Saffron flower on different stages of its physiological development contains important biologically active compounds (including: protocrocine, picrocrocine, crocine, safranal), which can affect on human organism and it is important to use saffron in food
Khositashvili, M. (M), Aleksandre Chalatashvili, Zaza Baazov, M. Khositashvili, Baazov, Z. (Zaza), Chalatashvili, A. (Aleksandre)   +5 more
core   +1 more source

Analgesic Effect of Safranal in Animal Model of Acute Pain; Possible role of the GABAergic Pathway

مجله علمی دانشگاه علوم پزشکی کردستان, 2020
Background and Aim: There are reports for analgesic, anti-inflammatory, hypnotic, neuroprotective and anti-oxidative effects of safranal. The aim of this study was to investigate the analgesic effects of safranal using acute pain method in rat and ...
Esmael Izadpanah, Elham Saei, Omid Abdollahi, Abbas Ahmadi, Mohammad Raman Moloudi   +4 more
doaj  

Optimized Isolation of Safranal from Saffron by Solid-Phase Microextraction (SPME) and Rotatable Central Composite Design-Response Surface Methodology (RCCD-RSM)

Separations, 2022
Safranal is the main aroma component of saffron stigmas. It is also a great antioxidant with known pharmacological properties and is a potent indicator for the grading and authentication of saffron.
Panagiota-Kyriaki Revelou, Spyridoula Mouzoula, Marinos Xagoraris, Haralambos Evangelaras, George K. Papadopoulos, Christos S. Pappas, Petros A. Tarantilis   +6 more
doaj   +1 more source

Safranal Alleviates Dextran Sulfate Sodium-Induced Colitis and Suppresses Macrophage-Mediated Inflammation

Frontiers in Pharmacology, 2019
Introduction:Crocus sativus (saffron) is widely used in China, Iran, and India for dyeing and as a food additive and medicinal plant. Safranal, as one of the main constituents of saffron, is responsible for its aroma and has been reported to have ...
Peeraphong Lertnimitphun, Yiwen Jiang, Nami Kim, Wenwei Fu, Changwu Zheng, Hongsheng Tan, Hua Zhou, Xue Zhang, Weizhong Pei, Yue Lu, Hongxi Xu, Hongxi Xu   +11 more
doaj   +1 more source

Eco‐Friendly ZnO–Chitosan Nanocomposite‐Embedded Sodium Alginate/Polyvinyl Alcohol/Saffron Hydrogel for Enhanced Antibacterial Applications [PDF]

IET Nanobiotechnol
This study reports the green synthesis, development, and characterization of novel eco‐friendly zinc oxide nanoparticles (ZnO NPs) coated with chitosan (ZnO NPs–Chsn) and their incorporation into a polyvinyl alcohol/sodium alginate/saffron (PSS) hydrogel for enhanced antibacterial applications. ZnO NPs were biosynthesized using quince (Cydonia oblonga)
Karampour F, Zendehcheshm S.
europepmc   +2 more sources

Therapeutic Potential of Origanum majorana L. Essential Oil in Diabetes Mellitus: Insights From GC–MS Characterization, In Vivo Hypoglycaemic Studies, and In Silico Analyses

Chemistry &Biodiversity, Volume 23, Issue 5, May 2026.
Exploring the chemical profile and biological property of O. majorana EO. ABSTRACT Diabetes mellitus is a widespread metabolic disorder characterized by impaired glucose regulation. This study investigated the chemical composition and antidiabetic potential of Origanum majorana essential oil (EO) using integrated in vitro, in vivo, and computational ...
Mahmoud Houas, Mohammed Larbi Benamor, Elhafnaoui Lanez, Yahia Bekkar, Lotfi Bourougaa, Ouafa Boudebia, Rania Bouraoui, Aicha Adaika, Nafila Zouaghi, Salah Neghmouche Nacer, Lazhar Bechki, Touhami Lanez, Stefania Garzoli   +12 more
wiley   +1 more source