Results 31 to 40 of about 490,934 (250)

Antibiofilm activity of mushroom extracts against Staphylococcus aureus

Annales Universitatis Paedagogicae Cracoviensis Studia Naturae, 2018
Mushrooms are a renowned source of products with an array of bioactivities, from antibacterial to antiviral, cytotoxic, antifeeding, antifungal or antioxidant and might be a valuable resource in the search of new bioactive extracts to inhibit biofilm ...
Anna Čuvalová , Imrich Strapáč, Livia Handrová, Vladimir Kmeť   +3 more
doaj   +1 more source

Structures of SAS-6 Suggest Its Organization in Centrioles

Science, 2011
Self-assembly of a centriolar protein may contribute to organizing the cartwheel-like hub and establishing centriole symmetry.
van Breugel, M, Hirono, M, Andreeva, A, Yanagisawa, H, Yamaguchi, S, Nakazawa, Y, Morgner, N, Petrovich, M, Ebong, I, Robinson, C, Johnson, C, Veprintsev, D, Zuber, B   +12 more
openaire   +3 more sources

SAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architecture [PDF]

Nature Cell Biology, 2016
Centrioles are critical for the formation of centrosomes, cilia and flagella in eukaryotes. They are thought to assemble around a nine-fold symmetric cartwheel structure established by SAS-6 proteins. Here, we have engineered Chlamydomonas reinhardtii SAS-6-based oligomers with symmetries ranging from five- to ten-fold.
Hilbert, Manuel, Noga, Akira, Frey, Daniel, Hamel, Virginie, Guichard, Paul, Kraatz, Sebastian H. W., Pfreundschuh, Moritz, Hosner, Sarah, Fluckiger, Isabelle, Jaussi, Rolf, Wieser, Mara M., Thieltges, Katherine M., Deupi, Xavier, Muller, Daniel, Kammerer, Richard A., Gonczy, Pierre, Hirono, Masafumi, Steinmetz, Michel O.   +17 more
openaire   +2 more sources

SAS-6 oligomerization: the key to the centriole?

Nature Chemical Biology, 2011
Centrioles are among the most beautiful of biological structures. How their highly conserved nine-fold symmetry is generated is a question that has intrigued cell biologists for decades. Two recent structural studies provide the tantalizing suggestion that the self-organizing properties of the SAS-6 protein hold the answer.
Cottee, M, Raff, J, Lea, S, Roque, H
openaire   +3 more sources

Mechanisms of HsSAS-6 assembly promoting centriole formation in human cells [PDF]

, 2014
SAS-6 proteins are thought to impart the ninefold symmetry of centrioles, but the mechanisms by which their assembly occurs within cells remain elusive. In this paper, we provide evidence that the N-terminal, coiled-coil, and C-terminal domains of HsSAS ...
Arquint, Azimzadeh, Azimzadeh, Beck, Bettencourt-Dias, Bornens, Bulseco, Carvalho-Santos, Cavalier-Smith, Chen, Chrétien, Cizmecioglu, Debora Keller, Dickson, Dippell, Dzhindzhev, Gopalakrishnan, Guichard, Guichard, Gönczy, Hatch, Haupts, Hoh, Jan Ellenberg, Kim, Kitagawa, Kleylein-Sohn, Kuriyama, Lau, Lawo, Leidel, Lettman, Lin, Lukinavičius, Maeder, Malte Wachsmuth, Marshall, Mennella, Meritxell Orpinell, Middendorp, Nakazawa, Nicolas Olivier, Nigg, Olivier, Olivier, Pierre Gönczy, Puklowski, Robert Mahen, Romain Wyss, Schmidt, Sonnen, Stevens, Strnad, Strnad, Strnad, Suliana Manley, van Breugel, Virginie Hachet, Vladar, Vulprecht, Wachsmuth   +60 more
core   +3 more sources

A GaAs-based self-aligned stripe distributed feedback laser [PDF]

, 2016
We demonstrate operation of a GaAs-based self-aligned stripe (SAS) distributed feedback (DFB) laser. In this structure, a first order GaInP/GaAs index-coupled DFB grating is built within the p-doped AlGaAs layer between the active region and the n-doped ...
Babazadeh, N., Childs, D.T., Fry, P.W, Groom, K.M., Groom, K.M., Lei, H., Stevens, B.J., Ternent, G.   +7 more
core   +2 more sources

Centrosomal Sas-6 in regulation of stem cells and aging [PDF]

, 2017
Gooi, Li Ming
openaire   +3 more sources

Identification and localization of SAS-6 in the microsporidium Nosema bombycis

Infection, Genetics and Evolution, 2019
The centriole in eukaryotes functions as the cell's microtubule-organizing center (MTOC) to nucleate spindle assembly. The evolutionarily conserved protein SAS-6 constitutes the center of the cartwheel assembly that scaffolds centrioles early in their biogenesis.
Weijiang, Dai, Nan, Li, Zhilin, Zhang, Gong, Chen, Xiaoliang, Li, Xiangran, Peng, Yiling, Zhang, Li, Xu, Zhongyuan, Shen   +8 more
openaire   +2 more sources

Surgical Apgar score as a predictor of outcomes in patients following laparotomy at Mulago National Referral Hospital, Uganda: a prospective cohort study

BMC Surgery, 2022
Background Postoperative complications and mortality following laparotomy have remained high worldwide. Early postoperative risk stratification is essential to improve outcomes and clinical care.
Bruno Chan Onen, Andrew Weil Semulimi, Felix Bongomin, Ronald Olum, Gideon Kurigamba, Ronald Mbiine, Olivia Kituuka   +6 more
doaj   +1 more source

Development of Novel Indole-Based Bifunctional Aldose Reductase Inhibitors/Antioxidants as Promising Drugs for the Treatment of Diabetic Complications

Molecules, 2021
Aldose reductase (AR, ALR2), the first enzyme of the polyol pathway, is implicated in the pathophysiology of diabetic complications. Aldose reductase inhibitors (ARIs) thus present a promising therapeutic approach to treat a wide array of diabetic ...
Lucia Kovacikova, Marta Soltesova Prnova, Magdalena Majekova, Andrej Bohac, Cimen Karasu, Milan Stefek   +5 more
doaj   +1 more source