Results 51 to 60 of about 120,121 (346)

PPARδ regulates satellite cell proliferation and skeletal muscle regeneration [PDF]

Skeletal Muscle, 2011
Abstract Peroxisome proliferator-activated receptors (PPARs) are a class of nuclear receptors that play important roles in development and energy metabolism. Whereas PPARδ has been shown to regulate mitochondrial biosynthesis and slow-muscle fiber types, its function in skeletal muscle progenitors (satellite cells) is unknown.
Angione, Alison R, Jiang, Chunhui, Pan, Dongning, Wang, Yong-Xu, Kuang, Shihuan   +4 more
openaire   +6 more sources

The emergence of Pax7-expressing muscle stem cells during vertebrate head muscle development [PDF]

, 2015
Pax7 expressing muscle stem cells accompany all skeletal muscles in the body and in healthy individuals, efficiently repair muscle after injury. Currently, the in vitro manipulation and culture of these cells is still in its infancy, yet muscle stem ...
Anna eNoble, Colin eSharpe, David J. Goldhamer, Erika C. Jorge, Gabrielle eKardon, Julia eMeireles Nogueira, Julia eMeireles Nogueira, Katarzyna eHawrot, Susanne eDietrich, William M. Wood   +9 more
core   +2 more sources

Targeting PKCθ promotes satellite cell self-renewal [PDF]

, 2020
Skeletal muscle regeneration following injury depends on the ability of satellite cells (SCs) to proliferate, self-renew, and eventually differentiate. The factors that regulate the process of self-renewal are poorly understood. In this study we examined
Benedetti, Anna, Bouché, Marina, Fiore, Piera Filomena, Lozanoska-Ochser, Biliana, Madaro, Luca   +4 more
core   +1 more source

Lsd1 regulates skeletal muscle regeneration and directs the fate of satellite cells

Nature Communications, 2018
Satellite cells are muscle stem cells required for muscle regeneration upon damage. Of note, satellite cells are bipotent and have the capacity to differentiate not only into skeletal myocytes, but also into brown adipocytes.
Milica Tošić, Anita Allen, Dominica Willmann, Christoph Lepper, Johnny Kim, D. Duteil, R. Schüle   +6 more
semanticscholar   +1 more source

Mammalian skeletal muscle fibres promote non-muscle stem cells and non-stem cells to adopt myogenic characteristics [PDF]

, 2017
Skeletal muscle fibres are unique cells in large animals, often composed of thousands of post-mitotic nuclei. Following skeletal muscle damage, resident stem cells called satellite cells commit to myogenic differentiation and migrate to carry out repair.
Henry, Collins-Hooper, Mitchell, Robert, Morash, Taryn, Patel, Ketan   +3 more
core   +4 more sources

The action of obestatin in skeletal muscle repair: stem cell expansion, muscle growth, and microenvironment remodeling [PDF]

, 2015
The development of therapeutic strategies for skeletal muscle diseases, such as physical injuries and myopathies, depends on the knowledge of regulatory signals that control the myogenic process. The obestatin/GPR39 system operates as an autocrine signal
ADAMO, Sergio, C. S. Mosteiro, D. l. Beiroa, F. F. Casanueva, I. Santos Zas, J. E. Viñuela, J. González Sánchez, J. M. Renaud, J. P. Camiña, J. Señarís, MORESI, Viviana, R. Gallego, R. Nogueiras, T. García Caballero, U. Gurriarán Rodríguez, W. Lin, Y. Pazos   +16 more
core   +1 more source

Impaired skeletal muscle regeneration in the absence of fibrosis during hibernation in 13-lined ground squirrels.

PLoS ONE, 2012
Skeletal muscle atrophy can occur as a consequence of immobilization and/or starvation in the majority of vertebrates studied. In contrast, hibernating mammals are protected against the loss of muscle mass despite long periods of inactivity and lack of ...
Eva Andres-Mateos, Rebeca Mejias, Arshia Soleimani, Brian M Lin, Tyesha N Burks, Ruth Marx, Benjamin Lin, Richard C Zellars, Yonggang Zhang, David L Huso, Tom G Marr, Leslie A Leinwand, Dana K Merriman, Ronald D Cohn   +13 more
doaj   +1 more source

Skeletal muscle in health and disease

Disease Models & Mechanisms, 2020
Skeletal muscle fibres are multinucleated cells that contain postmitotic nuclei (i.e. they are no longer able to divide) and perform muscle contraction.
Jennifer Morgan, Terence Partridge
doaj   +1 more source

Involvement of muscle satellite cell dysfunction in neuromuscular disorders: Expanding the portfolio of satellite cell-opathies

European Journal of Translational Myology, 2022
Neuromuscular disorders are a heterogeneous group of acquired or hereditary conditions that affect striated muscle function. The resulting decrease in muscle strength and motility irreversibly impacts quality of life.
Massimo Ganassi, Peter S. Zammit
doaj   +1 more source

Regeneration competent satellite cell niches in rat engineered skeletal muscle

FASEB BioAdvances, 2019
Satellite cells reside in defined niches and are activated upon skeletal muscle injury to facilitate regeneration. Mechanistic studies of skeletal muscle regeneration are hampered by the inability to faithfully simulate satellite cell biology in vitro ...
Malte Tiburcy, Alex Markov, Lena K. Kraemer, Peter Christalla, Margret Rave‐Fraenk, Henrike J. Fischer, Holger M. Reichardt, Wolfram‐Hubertus Zimmermann   +7 more
doaj   +1 more source