Results 51 to 60 of about 52,637 (292)

Biomimetic Nanocarrier Targeting Drug(s) to Upstream-Receptor Mechanisms in Dementia: Focusing on Linking Pathogenic Cascades

Biomimetics, 2020
Past published studies have already documented that, subsequent to the intravenous injection of colloidal lipid nanocarriers, apolipoprotein (apo)A-I is adsorbed from the blood onto the nanoparticle surface.
Joseph S. D’Arrigo
doaj   +1 more source

Identification and characterization of scavenger receptor class B member 2 in Nile tilapia (Oreochromis niloticus)

Aquaculture Reports, 2021
The class B scavenger receptors (scarb) are members of important pattern recognition receptors which play key roles for host immune response to pathogen infection.
Zijiong Dong, Bingxi Li, Liting Wu, Yang Lei, Jianlin Chen, Liangliang Mu, Hairong Wu, Meng Chen, Bei Wang, Jianmin Ye, Fang Liang   +10 more
doaj   +1 more source

The effects of exogenous lipid on THP-1 cells : an in vitro model of airway aspiration? [PDF]

, 2017
Chronic inflammatory diseases of the airways are associated with gastro-oesophageal reflux (GOR) and aspiration events. The observation of lipid laden macrophages (LLM) within the airway may indicate aspiration secondary to GOR.
Adams, Ahrens, Anderson, Greenman, Nakahira, Pacheco-Galván, Porcheray   +6 more
core   +2 more sources

Myricetin ameliorates atherosclerosis in the low-density-lipoprotein receptor knockout mice by suppression of cholesterol accumulation in macrophage foam cells

Nutrition & Metabolism, 2019
Background Myricetin, a major flavonoid found in several foods including berries, grapes and wine, exhibited strong antioxidant potency, yet the effect on atherosclerosis is not fully understood.
Zhe Meng, Mengyu Wang, Junhui Xing, Yuzhou Liu, Haiyu Li   +4 more
doaj   +1 more source

The role of cellular adhesion molecules in virus attachment and entry [PDF]

, 2015
As obligate intracellular parasites, viruses must traverse the host-cell plasma membrane to initiate infection. This presents a formidable barrier, which they have evolved diverse strategies to overcome.
Bhella, David
core   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Scara1 deficiency impairs clearance of soluble Amyloid-β by mononuclear phagocytes and accelerates Alzheimer’s-like disease progression [PDF]

, 2014
In Alzheimer’s disease soluble amyloid beta (sAβ) causes synaptic dysfunction and neuronal loss. Receptors involved in clearance of sAβ are not known. Here we use shRNA screening and identify the scavenger receptor Scara1 as a receptor for sAβ expressed ...
Frenkel, Dan, Wilkinson, Kim, Zhao, Lingzhi, Hickman, Suzanne E., Means, Terry K., Puckett, Lindsey, Farfara, Dorit, Kingery, Nathan D., Weiner, Howard L., El Khoury, Joseph   +9 more
core   +5 more sources

β-Amyloid promotes accumulation of lipid peroxides by inhibiting CD36-mediated clearance of oxidized lipoproteins

Journal of Neuroinflammation, 2004
Background Recent studies suggest that hypercholesterolemia, an established risk factor for atherosclerosis, is also a risk factor for Alzheimer's disease.
Khan Tayeba, Medeiros Lea A, Tseng Anita A, Kunjathoor Vidya V, Moore Kathryn J   +4 more
doaj   +1 more source

A Consensus Definitive Classification of Scavenger Receptors and Their Roles in Health and Disease [PDF]

, 2017
Scavenger receptors constitute a large family of proteins that are structurally diverse and participate in a wide range of biological functions. These receptors are expressed predominantly by myeloid cells and recognize a diverse variety of ligands ...
Acton, Acton, Aziz-Seible, Bartolome, Benita McVicker, Bridge, Casey, Chen, Cong, Cynthia L. Baldwin, Dachy, Dawn M. E. Bowdish, Debanne, Dzwonek, Endemann, Fogelman, Geoffrey M. Thiele, Guy, Janice C. Telfer, Joachim Herz, John Loike, Joseph El Khoury, Krieger, Kurt Drickamer, Lester Kobzik, Maria Febbraio, McVicker, McVicker, McVicker, Mercy R. PrabhuDas, Monty Krieger, Murphy, Newton, Paul L. Bollyky, Pike, Robert C. Speth, Ruppert, Samuel D. Wright, Samuel Silverstein, Soren K. Moestrup, Steven R. Post, Stockert, Tatsuya Sawamura, Terry K. Means, van der Laan, Wilkinson, Xiang-Yang Wang   +46 more
core   +1 more source

Scavenger Receptor Class B Type I Is a Plasma Membrane Cholesterol Sensor [PDF]

Circulation Research, 2013
Rationale: Signal initiation by the high-density lipoprotein (HDL) receptor scavenger receptor class B, type I (SR-BI), which is important to actions of HDL on endothelium and other processes, requires cholesterol efflux and the C-terminal transmembrane domain.
Sonika, Saddar, Véronique, Carriere, Wan-Ru, Lee, Keiji, Tanigaki, Ivan S, Yuhanna, Sajesh, Parathath, Etienne, Morel, Manya, Warrier, Janet K, Sawyer, Robert D, Gerard, Ryan E, Temel, J Mark, Brown, Margery, Connelly, Chieko, Mineo, Philip W, Shaul   +14 more
openaire   +2 more sources