Structural basis for voltage-sensor trapping of the cardiac sodium channel by a deathstalker scorpion toxin [PDF]
Nature Communications, 2021 The α-toxin LqhIII from the deathstalker scorpion inhibits fast inactivation of cardiac NaV1.5 channels. Here authors reveal the cryo-EM structure of LqhIII bound to NaV1.5 which shows that LqhIII traps the gating charges of the S4 segment in a unique ...
Daohua Jiang +6 more
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The scorpion toxin and the potassium channel [PDF]
eLife, 2013 The structure of a complex containing a toxin bound to a potassium ion channel has been solved for the first time, revealing how scorpions have designed toxins that can recognize and target the filter that controls the movement of potassium ions through ...
Kenton J Swartz
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Scorpion Toxin, BmP01, Induces Pain by Targeting TRPV1 Channel [PDF]
Toxins, 2015 The intense pain induced by scorpion sting is a frequent clinical manifestation. To date, there is no established protocol with significant efficacy to alleviate the pain induced by scorpion envenomation.
Md Abdul Hakim +6 more
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Fluorescent protein-scorpion toxin chimera is a convenient molecular tool for studies of potassium channels. [PDF]
Sci Rep, 2016 Ion channels play a central role in a host of physiological and pathological processes and are the second largest target for existing drugs. There is an increasing need for reliable tools to detect and visualize particular ion channels, but existing ...
Kuzmenkov AI +9 more
europepmc +4 more sources
The Scorpion Toxin Tf2 from Tityus fasciolatus Promotes Nav1.3 Opening. [PDF]
PLoS ONE, 2015 We identified Tf2, the first β-scorpion toxin from the venom of the Brazilian scorpion Tityus fasciolatus. Tf2 is identical to Tb2-II found in Tityus bahiensis. We found that Tf2 selectively activates human (h)Nav1.3, a neuronal voltage-gated sodium (Nav)
Thalita S Camargos +5 more
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Characterization and Chemical Synthesis of Cm39 (α-KTx 4.8): A Scorpion Toxin That Inhibits Voltage-Gated K+ Channel KV1.2 and Small- and Intermediate-Conductance Ca2+-Activated K+ Channels KCa2.2 and KCa3.1. [PDF]
Toxins (Basel), 2023 A novel peptide, Cm39, was identified in the venom of the scorpion Centruroides margaritatus. Its primary structure was determined. It consists of 37 amino acid residues with a MW of 3980.2 Da.
Naseem MU +9 more
europepmc +2 more sources
Scorpion toxin inhibits the voltage-gated proton channel using a Zn2+ -like long-range conformational coupling mechanism. [PDF]
Br J Pharmacol, 2020 Blocking the voltage‐gated proton channel HV1 is a promising strategy for the treatment of diseases like ischaemia stroke and cancer. However, few HV1 channel antagonists have been reported.
Tang D +9 more
europepmc +2 more sources
A bimodal activation mechanism underlies scorpion toxin-induced pain. [PDF]
Sci Adv, 2017 A scorpion toxin uses protons in the venom as coactivators to target nociceptive ion channel TRPV1 and cause pain. Venomous animals use peptide toxins for hunting and self-defense.
Yang S +7 more
europepmc +2 more sources
Intracerebral Hemorrhage Secondary to Scorpion Toxin in the Northwest of Argentina; A Case Report. [PDF]
Bull Emerg Trauma, 2018 Scorpionism is the clinical picture resulting from the inoculation of scorpion venom. It is considered a major public health problem, especially in countries with low resources and tropical or subtropical climate. Poisoning can be fatal especially in the
Bordón L +6 more
europepmc +2 more sources
Frontiers in Immunology, 2022 Scorpion envenoming is a severe health problem in many regions causing significant clinical toxic effects and fatalities. In the Middle East/North Africa (MENA) region, Buthidae scorpion stings are responsible for devastating toxic outcomes in human. The
Rahma Ben Abderrazek +14 more
doaj +2 more sources