Optimizing Scorpion Toxin Processing through Artificial Intelligence [PDF]
ToxinsScorpion toxins are relatively short cyclic peptides (
Adam Psenicnik +6 more
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Transcriptomic Analysis Reveals Diverse Expression of Scorpion Toxin Genes in Mesobuthus martensii [PDF]
ToxinsScorpions, an ancient group of venomous invertebrates, have existed for over 430 million years. Their toxins, important for predation and defense, exhibit a variety of biological and pharmacological activities.
Zhongxian Yang +5 more
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Kv1.3 channel blockade with the Vm24 scorpion toxin attenuates the CD4+ effector memory T cell response to TCR stimulation. [PDF]
Cell Commun Signal, 2018 In T cells, the Kv1.3 and the KCa3.1 potassium channels regulate the membrane potential and calcium homeostasis. Notably, during TEM cell activation, the number of Kv1.3 channels on the cell membrane dramatically increases.
Veytia-Bucheli JI +5 more
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hERG potassium channel blockage by scorpion toxin BmKKx2 enhances erythroid differentiation of human leukemia cells K562. [PDF]
PLoS ONE, 2013 The hERG potassium channel can modulate the proliferation of the chronic myelogenous leukemic K562 cells, and its role in the erythroid differentiation of K562 cells still remains unclear.The hERG potassium channel blockage by a new 36-residue scorpion ...
Jian Ma +5 more
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Evolution Stings: The Origin and Diversification of Scorpion Toxin Peptide Scaffolds
Toxins, 2013 The episodic nature of natural selection and the accumulation of extreme sequence divergence in venom-encoding genes over long periods of evolutionary time can obscure the signature of positive Darwinian selection.
Kartik Sunagar +6 more
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Frontiers in Immunology, 2020 Scorpionism is responsible for most accidents involving venomous animals in Brazil, which leads to severe symptoms that can evolve to death. Scorpion venoms consist of complexes cocktails, including peptides, proteins, and non-protein compounds, making ...
Caio B. Abreu +18 more
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Modulation of human Nav1.7 channel gating by synthetic α-scorpion toxin OD1 and its analogs [PDF]
Channels, 2015 Nine different voltage-gated sodium channel isoforms are responsible for inducing and propagating action potentials in the mammalian nervous system. The Nav1.7 channel isoform plays an important role in conducting nociceptive signals.
Leonid Motin +2 more
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A Cell-Penetrating Scorpion Toxin Enables Mode-Specific Modulation of TRPA1 and Pain. [PDF]
Cell, 2019 Lin King JV +6 more
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Cm28, a scorpion toxin having a unique primary structure, inhibits KV1.2 and KV1.3 with high affinity. [PDF]
J Gen Physiol, 2022 Naseem MU +8 more
europepmc +3 more sources
Transcriptome annotation and characterization of novel toxins in six scorpion species [PDF]
BMC Genomics, 2019 Background Venom has evolved in parallel in multiple animals for the purpose of self-defense, prey capture or both. These venoms typically consist of highly complex mixtures of toxins: diverse bioactive peptides and/or proteins each with a specific ...
Dwin G. B. Grashof +7 more
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