Results 21 to 30 of about 288,820 (252)
Hadrurid Scorpion Toxins: Evolutionary Conservation and Selective Pressures [PDF]
Toxins, 2019 Scorpion toxins are thought to have originated from ancestral housekeeping genes that underwent diversification and neofunctionalization, as a result of positive selection. Our understanding of the evolutionary origin of these peptides is hindered by the
Carlos E. Santibáñez-López +4 more
doaj +3 more sources
Toxins, 2021 Body tissue and venom glands from an eastern population of the scorpion Centruroides vittatus (Say, 1821) were homogenized and molecular constituents removed to characterize putative sodium β toxin gene diversity, RT-qPCR, transcriptomic, and proteomic ...
Aimee Bowman +4 more
doaj +1 more source
Mechanisms Underlying the Inhibition of KV1.3 Channel by Scorpion Toxin ImKTX58
Molecular Pharmacology, 2022 Voltage-gated KV1.3 channel has been reported to be a drug target for the treatment of autoimmune diseases, and specific inhibitors of Kv1.3 are potential therapeutic drugs for multiple diseases.
Xu Zhang +11 more
semanticscholar +1 more source
The European Zoological Journal, 2022 Scorpion venom plays an important role in scorpion predation, competition, communication, and defense. In this study, the species identification of Shandong scorpion and the analysis of venom extracted from male and female scorpion at the transcriptome ...
Y. Yang +12 more
doaj +1 more source
Scorpion toxin peptide action at the ion channel subunit level
Neuropharmacology, 2016 David M. Housley +3 more
openalex +3 more sources
Scorpion toxins interact with nicotinic acetylcholine receptors [PDF]
FEBS Letters, 2019 Neurotoxins are among the main components of scorpion and snake venoms. Scorpion neurotoxins affect voltage‐gated ion channels, while most snake neurotoxins target ligand‐gated ion channels, mainly nicotinic acetylcholine receptors (nAChRs). We report that scorpion venoms inhibit α‐bungarotoxin binding to both muscle‐type nAChR from Torpedo californica
Igor E. Kasheverov +13 more
openalex +3 more sources
The Oncologist, EarlyView., 2021 Abstract Lessons Learned Osimertinib has confirmed effectiveness in this real‐world population of patients with EGFR‐mutant advanced non‐small cell lung cancer. Thromboembolic events occur more frequently than previously reported, suggesting a thrombotic diathesis that requires further investigation. Patients with at least three metastatic sites, brain
Martina Lorenzi +21 more
wiley +1 more source
Genomic and structural characterization of Kunitz-type peptide LmKTT-1a highlights diversity and evolution of scorpion potassium channel toxins. [PDF]
PLoS ONE, 2013 BACKGROUND: Recently, a new subfamily of long-chain toxins with a Kunitz-type fold was found in scorpion venom glands. Functionally, these toxins inhibit protease activity and block potassium channels.
Zongyun Chen +10 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Scorpion α-toxins are neurotoxins that target the fast inactivation mechanism of voltage-gated sodium (NaV) channels leading to several neuro- and cardiotoxic effects in mammals.
Riadh Hmaidi +9 more
doaj +1 more source
Molecular biology and evolution, 2020 The growing resistance of insects to chemical pesticides is reducing the effectiveness of conventional methods for pest control and thus the development of novel insecticidal agents is imperative.
Shunyi Zhu +3 more
semanticscholar +1 more source