Results 31 to 40 of about 288,820 (252)
Recombinant expression and antigenicity of two peptide families of neurotoxins from Androctonus sp.
Journal of Venomous Animals and Toxins including Tropical Diseases, 2022 Background: Scorpion neurotoxins such as those that modify the mammalian voltage-gated sodium ion channels (Nav) are the main responsible for scorpion envenomation. Their neutralization is crucial in the production of antivenoms against scorpion stings.
Samuel Cardoso-Arenas +7 more
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Toxins, 2020 Here, we report the neurotoxic effects aroused by the intracerebral injection (in rats) of Tb1, which is a neurotoxin isolated from Tityus bahiensis scorpion venom. Biochemical analyses have demonstrated that this toxin is similar to the gamma toxin from
Emidio Beraldo Neto +4 more
doaj +1 more source
Animal Venoms as Peptide Libraries for the Discovery of Antiglioblastoma Agents. [PDF]
Biochem Res IntGlioblastoma is one of the most aggressive and widely recognized types of brain tumors, characterized by significant cellular and molecular diversity and an inherently aggressive nature. The treatment remains highly challenging, with limited effectiveness and persistently low survival rates.
Santiago LR +5 more
europepmc +2 more sources
Pharmacological Research, 2023 Animal venom is an important evolutionary innovation in nature. As one of the most representative animal venoms, scorpion venom contains an extremely diverse set of bioactive peptides.
Zhiqiang Xia +4 more
doaj +1 more source
Molecules, 2019 Scorpion toxins are well-known as the largest potassium channel peptide blocker family. They have been successfully proven to be valuable molecular probes for structural research on diverse potassium channels. The potassium channel pore region, including
Yonghui Zhao +4 more
doaj +1 more source
PLoS ONE, 2021 Scorpion venoms are mixtures of proteins, peptides and small molecular compounds with high specificity for ion channels and are therefore considered to be promising candidates in the venoms-to-drugs pipeline.
Freek J Vonk +8 more
doaj +2 more sources
Structural basis of α-scorpion toxin action on Nav channels
Science, 2019 How activation leads to gating Voltage-gated sodium (Nav) channels are key players in electrical signaling. Central to their function is fast inactivation, and mutants that impede this cause conditions such as epilepsy and pain syndromes.
T. Clairfeuille +14 more
semanticscholar +1 more source
Molecular Characterization of a Three-disulfide Bridges Beta-like Neurotoxin from Androctonus crassicauda Scorpion Venom [PDF]
Archives of Razi Institute, 2019 Scorpion venom is the richest source of peptide toxins with high levels of specific interactions with different ion-channel membrane proteins. The present study involved the amplification and sequencing of a 310-bp cDNA fragment encoding a beta-like ...
A. Jolodar
doaj +1 more source
Target-Driven Evolution of Scorpion Toxins [PDF]
Scientific Reports, 2015 AbstractIt is long known that peptide neurotoxins derived from a diversity of venomous animals evolve by positive selection following gene duplication, yet a force that drives their adaptive evolution remains a mystery. By using maximum-likelihood models of codon substitution, we analyzed molecular adaptation in scorpion sodium channel toxins from a ...
Shangfei Zhang, Bin Gao, Shunyi Zhu
openaire +2 more sources
Revista do Instituto de Medicina Tropical de São Paulo, 1989 Intravenous injection of scorpion toxin (Tityus serrulatus) in normal and Trypanosoma cruzi infected rats did not cause ultrastructural morphologic changes on enterochromaffin-like (ECL) cells of the stomach, although it induced a significant increase of
N. H. Toppa +6 more
doaj +1 more source