A multiplexed fluorescent assay for independent second-messenger systems: decoding GPCR activation in living cells. [PDF]
J Biomol Screen, 2013 There is a growing need in drug discovery and basic research to measure multiple second-messenger components of cell signaling pathways in real time and in relevant tissues and cell types.
Tewson PH, Quinn AM, Hughes TE.
europepmc +2 more sources
Pancreatic Beta Cell G-Protein Coupled Receptors and Second Messenger Interactions: A Systems Biology Computational Analysis. [PDF]
PLoS ONE, 2016 Insulin secretory in pancreatic beta-cells responses to nutrient stimuli and hormonal modulators include multiple messengers and signaling pathways with complex interdependencies.
Leonid E Fridlyand, Louis H Philipson
doaj +2 more sources
Bipolar Disorder and Obsessive Compulsive Disorder Comorbidity [PDF]
Psikiyatride Güncel Yaklaşımlar, 2014 The comorbidity of bipolar disorder and anxiety disorders is a well known concept. Obsessive-compulsive disorder is the most commonly seen comorbid anxiety disorder in bipolar patients.
Necla Keskin, Lut Tamam
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Second messenger systems in Tourette's syndrome
Journal of the Neurological Sciences, 1995 Abnormalities within second messenger systems have been hypothesized as the underlying pathophysiologic mechanism in a variety of neuropsychiatric disorders. In the Gilles de la Tourette syndrome (TS) prior studies have shown that the concentration of adenosine 3',5'-monophosphate (cAMP) is reduced in cortical and putamen brain regions.
H S, Singer +3 more
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Second Messenger Systems in Human Gliomas
Archives of Pathology & Laboratory Medicine, 2007 AbstractContext.—Patients with glioblastoma (astrocytoma, World Health Organization grade IV) exhibit 2-year survival rates of less than 20% despite significant advances in therapeutic options available to patients. Epidermal growth factor receptor (EGFR) hyperexpression is one of the most commonly encountered abnormalities in this tumor. However, EGFR
Roger E, McLendon +3 more
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The cyclic di-GMP receptor YcgR links the second messenger with the putrescine quorum sensing system in modulation of Dickeya oryzae motility [PDF]
mBioDickeya oryzae is a prevalent pathogen capable of infecting a variety of crops and plants, and its cell motility plays a key role in invasion of host and subsequent systemic infection. We recently demonstrated that the bacterial second messenger c-di-GMP
Weihan Gu +7 more
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New Journal of Physics, 2021 We consider a sequential cascade of molecular first-reaction events towards a terminal reaction centre in which each reaction step is controlled by diffusive motion of the particles.
Denis S Grebenkov +2 more
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Water-soluble cranberry extract inhibits Vibrio cholerae biofilm formation possibly through modulating the second messenger 3', 5' - Cyclic diguanylate level. [PDF]
PLoS ONE, 2018 Quorum sensing (QS) and nucleotide-based second messengers are vital signaling systems that regulate bacterial physiology in response to changing environments.
Daniel B Pederson +4 more
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Journal of Clinical and Translational Science, 2023 OBJECTIVES/GOALS: The goal of this proposal is to develop a technology that combines calcium imaging via confocal microscopy, and force measurement via monolayer stress microscopy to perform simultaneous quantitative measurements of agonist-induced Ca2 ...
Santina Johnson +9 more
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Arsenic Trioxide Modulates the Central Snail Neuron Action Potential
Journal of the Formosan Medical Association, 2009 The electropharmacological effect of arsenic trioxide (As2O3) is unknown. The present study investigated the effects of As2O3 on spontaneous neuronal impulse activity. Methods: Intracellular recordings and the two-electrode voltage clamp method were used
Guan-Ling Lu +4 more
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