Results 21 to 30 of about 1,865,436 (219)
Frontiers in Physiology, 2013 Mitochondria represent major sources of basal reactive oxygen species (ROS) production of the cardiomyocyte. The role of ROS as signalling molecules that mediate different intracellular pathways has gained increasing interest among physiologists in the ...
Verónica Celeste De Giusti +5 more
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Reactive oxygen species in disease: Rebuttal of a conventional concept
Journal of Controversies in Biomedical Research, 2015 The production of intracellular reactive oxygen species and reactive nitrogen species has long been proposed as leading to the random deleterious modification of macromolecules (i.e., nucleic acids, proteins) with an associated progressive development of
Luis Vitetta +2 more
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Cellular Tolerance Induced by Chronic Opioids in the Central Nervous System
Frontiers in Systems Neuroscience, 2022 Opioids are powerful analgesics that elicit acute antinociceptive effects through their action the mu opioid receptor (MOR). However opioids are ineffective for chronic pain management, in part because continuous activation of MORs induces adaptive ...
Sweta Adhikary, John T. Williams
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Precision cosmology from future lensed gravitational wave and electromagnetic signals [PDF]
, 2017 The standard siren approach of gravitational wave cosmology appeals to the direct luminosity distance estimation through the waveform signals from inspiralling double compact binaries, especially those with electromagnetic counterparts providing ...
Biesiada, Marek +4 more
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Information Content in Stochastic Pulse Sequences of Intracellular Messengers
Frontiers in Physics, 2018 Many cell signaling pathways rely on oscillatory messenger concentrations even to transduce aperiodic environmental changes. The universal second messenger calcium, Ca2+ often exhibits pulsatile behavior in the presence of constant concentrations of ...
Alan Givré +3 more
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Physiological Sensing of Carbon Dioxide/Bicarbonate/pH via Cyclic Nucleotide Signaling
Sensors, 2011 Carbon dioxide (CO2) is produced by living organisms as a byproduct of metabolism. In physiological systems, CO2 is unequivocally linked with bicarbonate (HCO3−) and pH via a ubiquitous family of carbonic anhydrases, and numerous biological processes are
Lonny R. Levin, Jochen Buck
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Brazilian Journal of Psychiatry, 2004 OBJETIVOS: Estudos pós-mortem, farmacológicos, de neuroimagem e em modelos animais têm demonstrado uma possível associação de mecanismos de sinalização intracelular na fisiopatologia do transtorno afetivo bipolar (TAB).
Benício Noronha Frey +4 more
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Second messenger systems and adaptation. [PDF]
Gut, 1987 Adaptive changes represent shifts in the equilibrium state of biologic systems in reponse to long standing alterations in their surrounding environment. Adaptation encompasses a variety of cellular changes ranging from very specific responses, such as variation in the production of a single protein, to broader responses including alterations in the ...
openaire +2 more sources
Luciferase complementation based-detection of G-protein-coupled receptor activity
BioTechniques, 2018 Protein complementation assays (PCA) are used as pharmacological tools, enabling a wide array of applications, ranging from studies of protein–protein interactions to second messenger effects.
Hideaki Yano +3 more
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Ecotoxicology and Environmental Safety, 2021 Studies about radiation damage in vivo are very significant for healthy risk assessment as well as cancer radiotherapy. Ceramide as a second messenger has been found to be related to radiation-induced apoptosis. However, the detailed mechanisms in living
Yaning Yang +6 more
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