Results 1 to 10 of about 622,739 (144)

Statin-dye conjugates for selective targeting of KRAS mutant cancer cells. [PDF]

PLoS ONE
Over 90% of pancreatic ductal adenocarcinoma (PDAC) patients involve KRAS mutations (KRASMUT), for which current treatment options are limited. Statins, commonly used to lower cholesterol, have demonstrated certain selective toxicity towards KRAS ...
Hye-Ran Moon, Zhenying Cai, Bo Kyung Cho, Hyeyoun Chang, Seung Taek Hong, Jean J Zhao, Ick Chan Kwon, Thomas M Roberts, Bumsoo Han, Ju Hee Ryu   +9 more
doaj   +2 more sources

Human variant of scavenger receptor BI (R174C) exhibits impaired cholesterol transport functions

Journal of Lipid Research, 2021
: HDL and its primary receptor, scavenger receptor class B type I (SR-BI), work together to promote the clearance of excess plasma cholesterol, thereby protecting against atherosclerosis. Human variants of SR-BI have been identified in patients with high
Sarah C. May, Jacqueline S. Dron, Robert A. Hegele, Daisy Sahoo   +3 more
doaj   +1 more source

Cancer-selective, single agent chemoradiosensitising gold nanoparticles [PDF]

, 2017
Two nanometre gold nanoparticles (AuNPs), bearing sugar moieties and/or thiol-polyethylene glycol-amine (PEG-amine), were synthesised and evaluated for their in vitro toxicity and ability to radiosensitise cells with 220 kV and 6 MV X-rays, using four ...
A Chompoosor, A Irure, A Pottier, AK Collins, Aquila Sharif, BD Chithrani, C Alric, C Zhu, C-J Liu, C-J Liu, CM Beddoes, D Kwatra, F Geng, F Xiao, GT Schaaff, H Hau, H Qian, HK Patra, I Fratoddi, J V Jokerst, JF Hainfeld, JF Hainfeld, JL Kelts, Jon P. Golding, K Haume, K Khoshgard, K Lee, Konstantina Tzelepi, KT Butterworth, L Sancey, M Gilles, M Luchette, Małgorzata A. Śmiałek, Meike Roskamp, MJ Hostetler, Nicky Whilde, Nigel J. Mason, P Chhour, P Page, Peter Goldie, Phil Williams, R Gromnicova, R Hong, RI Berbeco, Richard Slade-Carter, S Jain, SJ McMahon, SJ McMahon, Sophie Grellet, T Lund, WN Rahman, X Zhang, X-D Zhang, Y Manevich, Ying-Jan Wang   +54 more
core   +6 more sources

Overexpression of SR-BI by adenoviral vector promotes clearance of apoA-I, but not apoB, in human apoB transgenic mice

Journal of Lipid Research, 2002
Scavenger receptor BI (SR-BI) is a multi-ligand lipoprotein receptor that mediates selective lipid uptake from HDL, and plays a central role in hepatic HDL metabolism.
Nancy R. Webb, Maria C. de Beer, Jin Yu, Mark S. Kindy, Alan Daugherty, Deneys R. van der Westhuyzen, Frederick C. de Beer   +6 more
doaj   +1 more source

Cardio-Protection Afforded by Β-Blockade Is Maintained During Resistance Exercise [PDF]

, 2017
Objectives Whether or not the cardio-protective effect of β-adrenergic blockade is retained during resistance exercise has not been systematically evaluated.
Conviser, Jason M., Ng, Alexander V, Rockey, Shawn S., Thomas, D. Paul   +3 more
core   +2 more sources

Scavenger receptor-BI is a receptor for lipoprotein(a)

Journal of Lipid Research, 2013
Scavenger receptor class B type I (SR-BI) is a multi-ligand receptor that binds a variety of lipoproteins, including high density lipoprotein (HDL) and low density lipoprotein (LDL), but lipoprotein(a) [Lp(a)] has not been investigated as a possible ...
Xiao-Ping Yang, Marcelo J. Amar, Boris Vaisman, Alexander V. Bocharov, Tatyana G. Vishnyakova, Lita A. Freeman, Roger J. Kurlander, Amy P. Patterson, Lewis C. Becker, Alan T. Remaley   +9 more
doaj   +1 more source

Absorbate-Induced Piezochromism in a Porous Molecular Crystal [PDF]

, 2015
Atmospherically stable porous frameworks and materials are interesting for heterogeneous solid–gas applications. One motivation is the direct and selective uptake of pollutant/hazardous gases, where the material produces a measurable response in the ...
Butler, KT, Chen, T-H, Cruickshank, DL, Hendon, CH, Kaveevivitchai, W, Miljanic, OS, Popov, I, Walsh, A, Wilson, CC, Wittering, KE   +9 more
core   +3 more sources

Physiological importance of SR-BI in the in vivo metabolism of human HDL and LDL in male and female mice

Journal of Lipid Research, 2005
The physiological role of murine scavenger receptor class B type I (SR-BI) was evaluated by in vivo clearances of human HDL3 and LDL in normal and SR-BI knockout (KO) mice.
Mathieu R. Brodeur, Vilayphone Luangrath, Geneviève Bourret, Louise Falstrault, Louise Brissette   +4 more
doaj   +1 more source

LDL and HDL enriched in triglyceride promote abnormal cholesterol transport

Journal of Lipid Research, 2002
Hypertriglyceridemia induces multiple changes in lipoprotein composition. Here we investigate how one of these modifications, triglyceride (TG) enrichment, affects HDL and LDL function when this alteration occurs under conditions in which more polar ...
Josephine W. Skeggs, Richard E. Morton
doaj   +1 more source

Lipoprotein lipase mediates an increase in the selective uptake of high density lipoprotein-associated cholesteryl esters by hepatic cells in culture

Journal of Lipid Research, 1998
In this study the effect of lipoprotein lipase (LPL) on the selective uptake of high density lipoprotein (HDL) cholesteryl esters (CE) by hepatic cells was investigated.
Franz Rinninger, Tatjana Kaiser, W. Alexander Mann, Nicolette Meyer, Heiner Greten, Ulrike Beisiegel   +5 more
doaj   +1 more source