Results 41 to 50 of about 622,888 (291)

Minimally oxidized LDL inhibits macrophage selective cholesteryl ester uptake and native LDL-induced foam cell formation[S]

Journal of Lipid Research, 2014
Scavenger receptor-mediated uptake of oxidized LDL (oxLDL) is thought to be the major mechanism of foam cell generation in atherosclerotic lesions. Recent data has indicated that native LDL is also capable of contributing to foam cell formation via low ...
Jason M. Meyer, Ailing Ji, Lei Cai, Deneys R. van der Westhuyzen   +3 more
doaj   +1 more source

Hepatic SR-BI-mediated cholesteryl ester selective uptake occurs with unaltered efficiency in the absence of cellular energy

Journal of Lipid Research, 2006
Scavenger receptor class B type I (SR-BI) plays a critical role in the delivery of HDL cholesterol and cholesteryl esters (CEs) to liver and steroidogenic tissues by a selective process that does not result in significant degradation of HDL protein ...
Chris J. Harder, Gerard Vassiliou, Heidi M. McBride, Ruth McPherson   +3 more
doaj   +1 more source

Effect of selective heart rate slowing in heart failure with preserved ejection fraction [PDF]

, 2015
Background Heart failure with preserved ejection fraction (HFpEF) is associated with significant morbidity and mortality but is currently refractory to therapy.
Ashrafian, Houman, Dawson, Dana K., Dwight, Jeremy S., Francis, Jane M., Frenneaux, Michael, Mahmod, Masliza, Neubauer, Stefan, Pal, Nikhil, Rudd, Amelia, Singh, Satnam, Sivaswamy, Nadiya, Watkins, Hugh, Yavari, Arash   +12 more
core   +2 more sources

Changes in Body Composition in Children and Young People Undergoing Treatment for Acute Lymphoblastic Leukemia: A Systematic Review and Meta‐Analysis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Ongoing evidence indicates increased risk of sarcopenic obesity among children and young people (CYP) with acute lymphoblastic leukemia (ALL), often beginning early in treatment, persisting into survivorship. This review evaluates current literature on body composition in CYP with ALL during and after treatment.
Lina A. Zahed, Raquel Revuelta Iniesta, Mary Fewtrell, Julie Lanigan, Breeana Gardiner, Graeme O'Connor   +5 more
wiley   +1 more source

Selective uptake of HDL cholesteryl esters and cholesterol efflux from mouse peritoneal macrophages independent of SR-BI

Journal of Lipid Research, 2006
Scavenger receptor class B type I (SR-BI) mediates the selective uptake of HDL cholesteryl esters (CEs) and facilitates the efflux of unesterified cholesterol. SR-BI expression in macrophages presumably plays a role in atherosclerosis.
May Brundert, Joerg Heeren, Mukaddes Bahar-Bayansar, Anne Ewert, Kathryn J. Moore, Franz Rinninger   +5 more
doaj   +1 more source

AKT activation controls cell survival in response to HDAC6 inhibition. [PDF]

, 2016
HDAC6 is emerging as an important therapeutic target for cancer. We investigated mechanisms responsible for survival of tumor cells treated with a HDAC6 inhibitor.
Aboagye, EO, Ali, T, Kaliszczak, M, Trousil, S   +3 more
core   +1 more source

Characterizing Parental Concerns About Lasting Impacts of Treatment in Children With B‐Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background B‐acute lymphoblastic leukemia (B‐ALL) is the most common pediatric cancer, and while most children in high‐resource settings are cured, therapy carries risks for long‐term toxicities. Understanding parents’ concerns about these late effects is essential to guide anticipatory support and inform evolving therapeutic approaches ...
Kellee N. Parker, Sarah W. Alexander, Lisa M. Jacola, Kimberly A. Buff, Kyobin Hwang, Elham Hashemi, Gregory Stoddard, Lindsay A. Jibb   +7 more
wiley   +1 more source

Selective uptake of HDL cholesteryl esters is active in transgenic mice expressing human apolipoprotein A-I.

Journal of Lipid Research, 1995
The direct non-endocytotic uptake of cholesteryl esters (CE) from high density lipoprotein (HDL) plays a major role in HDL CE metabolism in rats and rabbits. In vitro evidence indicates it may also play such a role in humans.
J C Khoo, R C Pittman, E M Rubin
doaj   +1 more source

All-inorganic core-shell silica-titania mesoporous colloidal nanoparticles showing orthogonal functionality [PDF]

, 2011
Colloidal mesoporous silica (CMS) nanoparticles with a thin titania-enriched outer shell showing a spatially resolved functionality were synthesized by a delayed co-condensation approach.
Abe, Bartl, Cauda, Cauda, Dina Fattakhova-Rohlfing, Dong, Eimer, Fattakhova-Rohlfing, Fernandez, Garnweitner, Grätzel, Hagfeldt, Johann M. Szeifert, Karin Merk, Kecht, Kobler, Kobler, Kobler, Lechmann, Lee, Lee, Li, Li, Nazeeruddin, Oh, Orignac, Pan, Sahu, Schlossbauer, Szeifert, Thomas Bein, Valentina Cauda, Zhao   +32 more
core   +1 more source

A Comparative Study of Cerebral Oxygenation During Exercise in Hemodialysis and Peritoneal Dialysis Patients

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Cognitive impairment and exercise intolerance are common in dialysis patients. Cerebral perfusion and oxygenation play a major role in both cognitive function and exercise execution; HD session per se aggravates cerebral ischemia in this population. This study aimed to compare cerebral oxygenation and perfusion at rest and in mild
Marieta P. Theodorakopoulou, Konstantina Dipla, Danai Faitatzidou, Fotini Iatridi, Areti Georgiou, Artemios Karagiannidis, Erasmia Sampani, Chrysostomos Dimitriadis, Aggelos Koutlas, Andreas Zafeiridis, Pantelis Sarafidis   +10 more
wiley   +1 more source