Results 11 to 20 of about 56,769 (258)

Progress in researches on self-amplifying RNA vaccines

Zhongguo gonggong weisheng, 2023
Self-amplifying RNA (saRNA) vaccines are a new generation of mRNA vaccines. In addition to containing mRNA sequences encoding antigen proteins, saRNA vaccines also have unique self-amplifying elements, so self-amplification of antigen sequences can be ...
Shuo WANG, Jianmin LI
doaj   +2 more sources

Self-Amplifying Replicon RNA Delivery to Dendritic Cells by Cationic Lipids [PDF]

Molecular Therapy: Nucleic Acids, 2018
Advances in RNA technology during the past two decades have led to the construction of replication-competent RNA, termed replicons, RepRNA, or self-amplifying mRNA, with high potential for vaccine applications.
Pavlos C. Englezou, Cedric Sapet, Thomas Démoulins, Panagiota Milona, Thomas Ebensen, Kai Schulze, Carlos-Alberto Guzman, Florent Poulhes, Olivier Zelphati, Nicolas Ruggli, Kenneth C. McCullough   +10 more
doaj   +4 more sources

Self-Amplifying Replicon RNA Vaccine Delivery to Dendritic Cells by Synthetic Nanoparticles [PDF]

Vaccines, 2014
Dendritic cells (DC) play essential roles determining efficacy of vaccine delivery with respect to immune defence development and regulation. This renders DCs important targets for vaccine delivery, particularly RNA vaccines.
Kenneth C. McCullough, Panagiota Milona, Lisa Thomann-Harwood, Thomas Démoulins, Pavlos Englezou, Rolf Suter, Nicolas Ruggli   +6 more
doaj   +4 more sources

Controlling reactogenicity while preserving immunogenicity from a self-amplifying RNA vaccine by modulating nucleocytoplasmic transport [PDF]

npj Vaccines
Self-amplifying RNA (saRNA)-based vaccines have emerged as a potent and durable RNA vaccine platform relative to first generation mRNA vaccines. However, RNA vaccine platforms trigger undesirable side effects at protective doses, underscoring the need ...
Jason A. Wojcechowskyj, Robyn M. Jong, Imre Mäger, Britta Flach, Paul V. Munson, Progya P. Mukherjee, Barbara Mertins, Katherine R. Barcay, Thomas Folliard   +8 more
doaj   +2 more sources

A phase I COVID-19 vaccine trial among SARS-CoV-2 seronegative and seropositive individuals in Uganda utilizing a self-amplifying RNA vaccine platform: Screening and enrollment experiences [PDF]

Human Vaccines & Immunotherapeutics, 2023
We report the screening and enrollment process for a phase I vaccine trial in Masaka, Uganda that investigated the safety and immunogenicity of a self-amplifying SARS-CoV-2 RNA vaccine amongst individuals with and without antibodies to SARS-CoV-2 ...
Jonathan Kitonsa, Onesmus Kamacooko, Eugene Ruzagira, Florence Nambaziira, Andrew Abaasa, Jennifer Serwanga, Ben Gombe, Jane Lunkuse, Hadijah Naluyinda, Naboth Tukamwesiga, Tamara Namata, Antony Kigozi, Paddy Kafeero, Vincent Basajja, Sarah Joseph, Benjamin F. Pierce, Robin Shattock, Pontiano Kaleebu   +17 more
doaj   +2 more sources

Cholesterol‐Amino‐Phosphate (CAP) Derived Lipid Nanoparticles for Delivery of Self‐Amplifying RNA and Restoration of Spermatogenesis in Infertile Mice [PDF]

Advanced Science, 2023
Male infertility caused by genetic mutations is an important type of infertility. Currently, there is no reliable method in the clinic to address this medical need.
Shi Du, Wenqing Li, Yuebao Zhang, Yonger Xue, Xucheng Hou, Jingyue Yan, Jeffrey Cheng, Binbin Deng, David W. McComb, Jennifer Lin, Hong Zeng, Xiaolin Cheng, Darrell J. Irvine, Ron Weiss, Yizhou Dong   +14 more
doaj   +2 more sources

COVAC1 phase 2a expanded safety and immunogenicity study of a self-amplifying RNA vaccine against SARS-CoV-2Research in context [PDF]

EClinicalMedicine, 2023
Summary: Background: Lipid nanoparticle (LNP) encapsulated self-amplifying RNA (saRNA) is well tolerated and immunogenic in SARS-CoV-2 seronegative and seropositive individuals aged 18–75.
Alex J. Szubert, Katrina M. Pollock, Hannah M. Cheeseman, Jasmini Alagaratnam, Henry Bern, Olivia Bird, Marta Boffito, Ruth Byrne, Tom Cole, Catherine A. Cosgrove, Saul N. Faust, Sarah Fidler, Eva Galiza, Hana Hassanin, Mohini Kalyan, Vincenzo Libri, Leon R. McFarlane, Ana Milinkovic, Jessica O'Hara, David R. Owen, Daniel Owens, Mihaela Pacurar, Tommy Rampling, Simon Skene, Alan Winston, James Woolley, Yee Ting N. Yim, David T. Dunn, Sheena McCormack, Robin J. Shattock   +29 more
doaj   +2 more sources

Neutrophil extracellular trap-associated RNA and LL37 enable self-amplifying inflammation in psoriasis [PDF]

Nature Communications, 2020
Antimicrobial peptide LL37 can bind nucleic acids and potentiate their sensing by endosomal TLRs. Here the authors show that LL37 binds to RNA from neutrophil extracellular traps (NETs), which amplifies inflammation and production of more LL37 and NETs ...
Franziska Herster, Zsofia Bittner, Nathan K. Archer, Sabine Dickhöfer, David Eisel, Tatjana Eigenbrod, Thomas Knorpp, Nicole Schneiderhan-Marra, Markus W. Löffler, Hubert Kalbacher, Tim Vierbuchen, Holger Heine, Lloyd S. Miller, Dominik Hartl, Lukas Freund, Knut Schäkel, Martin Heister, Kamran Ghoreschi, Alexander N. R. Weber   +18 more
doaj   +3 more sources

Development of nucleic acid vaccines: use of self-amplifying RNA in lipid nanoparticles

International Journal of Nanomedicine, 2014
Alicia Rodríguez-Gascón, Ana del Pozo-Rodríguez, María Ángeles SolinísPharmacokinetic, Nanotechnology and Gene Therapy Group (PharmaNanoGene), Faculty of Pharmacy, Centro de Investigación Lascaray ...
Rodríguez-Gascón A, del Pozo-Rodríguez A, Solinís MA   +2 more
doaj   +6 more sources

Self-Amplifying RNA Approach for Protein Replacement Therapy. [PDF]

Int J Mol Sci, 2022
Messenger RNA (mRNA) technology has already been successfully tested preclinically and there are ongoing clinical trials for protein replacement purposes; however, more effort has been put into the development of prevention strategies against infectious diseases.
Papukashvili D, Rcheulishvili N, Liu C, Ji Y, He Y, Wang PG.   +5 more
europepmc   +3 more sources