Results 31 to 40 of about 56,769 (258)

Conjugation of Mannans to Enhance the Potency of Liposome Nanoparticles for the Delivery of RNA Vaccines

Pharmaceutics, 2021
Recent approval of mRNA vaccines to combat COVID-19 have highlighted the potential of this platform. Lipid nanoparticles (LNP) is the delivery vehicle of choice for mRNA as they prevent its enzymatic degradation by encapsulation.
Roshan Goswami, Derek T. O’Hagan, Roberto Adamo, Barbara C. Baudner   +3 more
doaj   +1 more source

A Phase I/II Clinical Trial of Intradermal, Controllable Self-Replicating Ribonucleic Acid Vaccine EXG-5003 against SARS-CoV-2

Vaccines, 2023
mRNA vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have played a key role in reducing morbidity and mortality from coronavirus disease 2019 (COVID-19).
Takenao Koseki, Mayumi Teramachi, Minako Koga, Minoru S. H. Ko, Tomokazu Amano, Hong Yu, Misa Amano, Erica Leyder, Maria Badiola, Priyanka Ray, Jiyoung Kim, Akihiro C. Ko, Achouak Achour, Nan-ping Weng, Takumi Imai, Hisako Yoshida, Satsuki Taniuchi, Ayumi Shintani, Hidetsugu Fujigaki, Masashi Kondo, Yohei Doi   +20 more
doaj   +1 more source

Nonviral delivery of self-amplifying RNA vaccines [PDF]

Proceedings of the National Academy of Sciences, 2012
Despite more than two decades of research and development on nucleic acid vaccines, there is still no commercial product for human use. Taking advantage of the recent innovations in systemic delivery of short interfering RNA (siRNA) using lipid nanoparticles (LNPs), we developed a self-amplifying RNA vaccine.
Andrew J, Geall, Ayush, Verma, Gillis R, Otten, Christine A, Shaw, Armin, Hekele, Kaustuv, Banerjee, Yen, Cu, Clayton W, Beard, Luis A, Brito, Thomas, Krucker, Derek T, O'Hagan, Manmohan, Singh, Peter W, Mason, Nicholas M, Valiante, Philip R, Dormitzer, Susan W, Barnett, Rino, Rappuoli, Jeffrey B, Ulmer, Christian W, Mandl   +18 more
openaire   +2 more sources

The next generation of RNA vaccines: self-amplifying RNA [PDF]

The Biochemist, 2021
The global COVID-19 pandemic has brought tremendous momentum to the field of messenger RNA (mRNA) vaccines. The advantages of this vaccine platform, such as rapid development and high efficacy, resulted in mRNA vaccines being the first approved vaccines against COVID-19.
openaire   +1 more source

Can self-amplifying RNA vaccines and viruses exchange genetic material? [PDF]

Mol Ther
Casmil IC, Blakney AK.
europepmc   +3 more sources

Design-of-experiments in vitro transcription yield optimization of self-amplifying RNA [PDF]

F1000Research, 2021
Background: Self-amplifying RNA (saRNA) vaccines are able to induce a higher antigen-specific immune response with a more cost-effective and rapid production process compared to plasmid DNA vaccines. saRNAs are synthesized through in vitro transcription (IVT); however ...
Karnyart Samnuan, Anna K. Blakney, Paul F. McKay, Robin J. Shattock   +3 more
openaire   +3 more sources

Heterologous saRNA Prime, DNA Dual-Antigen Boost SARS-CoV-2 Vaccination Elicits Robust Cellular Immunogenicity and Cross-Variant Neutralizing Antibodies

Frontiers in Immunology, 2022
We assessed if immune responses are enhanced in CD-1 mice by heterologous vaccination with two different nucleic acid-based COVID-19 vaccines: a next-generation human adenovirus serotype 5 (hAd5)-vectored dual-antigen spike (S) and nucleocapsid (N ...
Adrian Rice, Mohit Verma, Emily Voigt, Peter Battisti, Sam Beaver, Sierra Reed, Kyle Dinkins, Shivani Mody, Lise Zakin, Shiho Tanaka, Brett Morimoto, C. Anders Olson, Elizabeth Gabitzsch, Jeffrey T. Safrit, Patricia Spilman, Corey Casper, Corey Casper, Patrick Soon-Shiong   +17 more
doaj   +1 more source

Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation. [PDF]

, 2005
Maternal embryonic leucine zipper kinase (MELK) was previously identified in a screen for genes enriched in neural progenitors. Here, we demonstrate expression of MELK by progenitors in developing and adult brain and that MELK serves as a marker for self-
Bajpai, Ruchi, Dougherty, Joseph D, Freije, William A, Geschwind, Daniel H, Groszer, Matthias, Imura, Tetsuya, Kelly, Theresa K, Kim, Kevin J, Kornblum, Harley I, Liu, Xin, Nakano, Ichiro, Nelson, Stanley F, Ou, Jing, Paucar, Andres A, Sofroniew, Michael V, Terskikh, Alexey V, Wu, Hong, Zewail, Amani   +17 more
core   +2 more sources

Perspectives on RNA Vaccine Candidates for COVID-19

Frontiers in Molecular Biosciences, 2021
With the current outbreak caused by SARS-CoV-2, vaccination is acclaimed as a public health care priority. Rapid genetic sequencing of SARS-CoV-2 has triggered the scientific community to search for effective vaccines.
Pobitra Borah, Pobitra Borah, Pran Kishore Deb, Nizar A. Al-Shar’i, Lina A. Dahabiyeh, Katharigatta N. Venugopala, Katharigatta N. Venugopala, Vinayak Singh, Vinayak Singh, Pottathil Shinu, Snawar Hussain, Satyendra Deka, Balakumar Chandrasekaran, Da’san M. M. Jaradat   +13 more
doaj   +1 more source

Efficient Protein Expression and Virus-Induced Gene Silencing in Plants Using a Crinivirus-Derived Vector. [PDF]

, 2018
Plant virus-based vectors are valuable tools for recombinant gene expression and functional genomics for both basic and applied research. In this study, Lettuce infectious yellows virus (LIYV) of the genus Crinivirus was engineered into a virus vector ...
Falk, Bryce W, Qiao, Wenjie
core   +3 more sources