Results 71 to 80 of about 5,913,725 (281)

Self-Directed Learning for the 21st Century : implications for Higher Education [PDF]

, 2019
This book is devoted to scholarship in the field of self-directed learning in the 21st century, with specific reference to higher education. The target audience of the book includes scholars in the field of self-directed learning and higher education ...
Bailey, Roxanne, Mentz, Elsa, De Beer, Josef   +2 more
core  

DEVELOPMENT OF WEB BASED SELF ASSESSMENT AND ENVIRONMENTAL PROBLEM SOLVING TEST FOR GEO INQUIRY BASED COMMUNITY SERVICE LEARNING MODEL

, 2023
<p><strong>Abstract</strong></p><p>Geo-Inquiry-based Community Service Learning is a learning model designed to increase higher-order thinking skills through a scientific process by carrying out community service activities.
TUTI MUTIA, RIMA MEILITA SARI, RIDHWAN, FAIZ URFAN, TENGKU MUHAMMAD SAHUDRA   +4 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Optimising the Community of Inquiry principles of online self-directed learning environments

, 2021
Chantelle Bosch, Dorothy Laubscher, Jako Olivier   +2 more
openaire   +3 more sources

Investigating self-directed learning and technology readiness in blending learning environment

International Journal of Educational Technology in Higher Education, 2019
Blended Learning (BL) creates a ‘rich’ educational environment with multiple technology-enabled communication forms in both face-to-face and online teaching.
Shuang Geng, Kris M. Y. Law, Ben Niu
doaj   +1 more source

Further studies in self-directed learning in physics at the University of Limerick, Ireland

, 2018
This article reports on two SDL studies of undergraduate physics students and postgraduate science students at the University of Limerick, Ireland. Initial studies (McCauley and McClelland, 2001) indicated that the majority of undergraduate physics ...
McClelland, George, McCauley, Veronica
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Self-Directed Learning in Italy: Problems and Possibilities

, 2008
This article presents the evolution of the idea of self-directed learning in Italy through three major phases. At the end of the twentieth century, self-directed learning became identified with techniques of self-instruction for adults unable to ...
BIASIN, CHIARA
core  

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source