Results 91 to 100 of about 8,472,955 (236)

USP5 Stabilizes TGFBR1 to Drive Vascular Smooth Muscle Cell Senescence and Atherosclerosis

Advanced Science, EarlyView.
This study reveals that USP5 drives vascular smooth muscle cell senescence and atherosclerosis by stabilizing TGFBR1, suppressing IDH2, and promoting glycolytic reprogramming, identifying the USP5‐TGFBR1‐IDH2 axis as a potential therapeutic target. ABSTRACT Vascular smooth muscle cell (VSMC) senescence contributes importantly to atherosclerotic plaque ...
Xinhai Cui, Yuanlong Hu, Lin Lin, Lei Zhang, Chao Li, Yunlun Li   +5 more
wiley   +1 more source

NAD+ metabolism controls inflammation during senescence

Molecular & Cellular Oncology, 2019
We have recently discovered that nicotinamide adenine dinucleotide metabolism controls the pro-inflammatory senescence-associated secretory phenotype during cellular senescence.
Timothy Nacarelli, Rugang Zhang
doaj   +1 more source

Fibrillarin Resists Cellular Senescence Via SIRT1‐Dependent Nicotinamide Metabolism and Its Inhibition Sensitizes Senolytic Therapy in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
FBL directly binds to and stabilizes SIRT1 by blocking its ubiquitin‐proteasome degradation, thereby sustaining nicotinamide metabolism and redox homeostasis to counteract cellular senescence in ESCC. Genetic and pharmacological suppression of FBL sensitizes tumor cells to senolytic therapy.
Xing Jin, Hong Liu, Ling Gao, Lei Liu, Ji‐Bin Liu, Xiaoxia Jin, Ming‐Song Wang, Dan Liu, Li Feng, Wen‐Lian Chen   +9 more
wiley   +1 more source

Maternal Exercise Rescues Embryonic Osteogenesis Impaired due to POLG Mutation Through a Potential Apelin‐ATF4 Axis

Advanced Science, EarlyView.
Maternal exercise (ME) increases apelin abundance across maternal and fetal tissues and is associated with improved fetal osteogenesis under POLG mutation‐induced mitochondrial dysfunction. Apelin‐APJ signaling is linked to enhanced mitochondrial function, Akt phosphorylation, and ATF4‐RUNX2 association, supporting coordinated fetal bone remodeling ...
Song Ah Chae, Ryan C. Riddle, Zhihua Jiang, Chaeyoung Shin, Min Du, Jun Seok Son   +5 more
wiley   +1 more source

Corrigendum: The Paradoxical Role of Cellular Senescence in Cancer

Frontiers in Cell and Developmental Biology, 2021
Jing Yang, Jing Yang, Mengmeng Liu, Mengmeng Liu, Dongchun Hong, Dongchun Hong, Musheng Zeng, Xing Zhang   +7 more
doaj   +1 more source

Redox metabolism in cell senescence: focusing on contributions from the metabolomic field

Frontiers in Molecular Biosciences
Cell senescence is triggered by stressful stimuli, including telomere attrition, genotoxic agents, and strong mitogenic signals. This state is characterized by proliferation arrest and acquisition of a senescence-associated secretory phenotype. Senescent
Eliana Chacón, Guillermo Grünwaldt, Inés Marmisolle, Jennyfer Martínez, Celia Quijano   +4 more
doaj   +1 more source

OTUD6A‐Mediated Deubiquitination of PRDX1 Protects Against Oral Ulcer by Restoring Mitochondrial Function

Advanced Science, EarlyView.
In human oral keratinocytes, OTUD6A promoted cell migration by deubiquitinating and stabilizing PRDX1. Conversely, OTUD6A deficiency reduced PRDX1 stability, triggering mitochondrial dysfunction and aggravating OU progression. ABSTRACT Oral ulcers (OU), as the most highly prevalent and recurrent oral mucosal lesion, have an unclear pathogenesis that ...
Xiaoyu Sun, Ruiwei Jia, Xingbei Pan, Rui Huang, Jiahong Chen, Ziyi Yao, Lei Yin, Jun Ma, Hongjieliang Wang, Xinyu Huang, Yilin Ma, Yifan Ping, Yuanyuan Chen, Huining Wang, Shengbin Huang, Guang Liang   +15 more
wiley   +1 more source

Epilipidomics of Senescent Dermal Fibroblasts Identify Lysophosphatidylcholines as Pleiotropic Senescence-Associated Secretory Phenotype (SASP) Factors

, 2020
Während des Alterns sammelt die Haut seneszente Zellen an. Die vorübergehende Anwesenheit von seneszenten Zellen, gefolgt von ihrer Clearance durch das Immunsystem, ist wichtig für die Gewebereparatur und Homöostase.
Pils, Vera; orcid:, Nagelreiter, Ionela-Mariana; orcid:, Mildner, Michael; orcid:, Baier, Alina, Wedel, Sophia; orcid:, Rubelj, Ivica; orcid:, El-Ghalbzouri, Abdoelwaheb; orcid:, Cavinato, Maria; orcid:, Bayer, Alina, Narzt, Marie-Sophie; orcid:, Bessonova, Emilia; orcid:, Grillari, Johannes; orcid:, Waidhofer-Söllner, Petra; orcid:, Zoratto, Samuele; orcid:, Marchetti-Deschmann, Martina; orcid:, Terlecki-Zaniewicz, Lucia; orcid:, Nanic, Lucia; orcid:, Gruber, Florian; orcid:, Jansen-Dürr, Pidder; orcid:, Lämmermann, Ingo; orcid:, Schosserer, Markus; orcid:, Reifschneider, Raffaela; orcid:, Narzt, Marie; orcid:, Nagelreiter, Ionnela; orcid:, Ghalbzouri, Abdoel, Tschachler, Erwin; orcid:, Kremslehner, Christopher; orcid:   +26 more
core   +1 more source

Polystyrene Nanoplastics Drive β‐Cell Dedifferentiation Through Dendritic Cell‐Intrinsic MHC‐I‐Dependent Inflammatory Crosstalk

Advanced Science, EarlyView.
Polystyrene nanoplastics disrupt pancreatic immune–endocrine homeostasis by promoting MHC‐I‐associated dendritic cell activation and inflammatory crosstalk with β cells. This immune remodeling drives β‐cell dedifferentiation, impairs insulin secretion, and aggravates metabolic dysfunction, revealing a previously unrecognized immunometabolic mechanism ...
Conghui Qiao, Yuqing Song, Fang Yang, Menghui Guo, Libin Jiang, Xiaoyue Quan, Wei Wei, Xinyang Wang, Tianshu Han, Mingyuan Liu, Wenbo Jiang   +10 more
wiley   +1 more source

HMGB2 orchestrates the chromatin landscape of senescence-associated secretory phenotype gene loci [PDF]

, 2016
Cellular senescence is a stable cell growth arrest that is characterized by the silencing of proliferation-promoting genes through compaction of chromosomes into senescence-associated heterochromatin foci (SAHF).
Bitler B., Noma K., Tanizawa H., Le L., Kossenkov A., Zhang R., Yang T., Iwasaki O., Fatkhutdinov N., Johnson F., Aird K., Alicea G.   +11 more
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