Results 81 to 90 of about 8,472,955 (236)

TPI1 Loss Triggers a Metabolite‐Driven Mitochondrial Redox Vulnerability via the SARM1–cADPR–Ca2+ Axis

Advanced Science, EarlyView.
Metabolite‐driven redox stress governs cancer cell senescence. TPI1 deficiency elevates DHAP, initiating SARM1‐dependent cADPR‐Ca2+ release. Mitochondrial ROS surge subsequently induces DNA damage and senescence, offering a conserved therapeutic target in multiple cancers.
Chunyu Liu, Shun Wu, Chuang Wang, Zirui Zhou, Tianwei Cai, Wen Tao, Shidong Zuo, Chi Zhang, Yuhao Dong, Yi Feng, Qingbo Huang, Baojun Wang, Xin Ma, Haoli Ma, Xu Zhang, Yan Huang   +15 more
wiley   +1 more source

Trafficking Deficiency of TMEM175 Variants in Parkinson's Disease Pathogenesis and the Prospects of Precision Medicine

Advanced Science, EarlyView.
This study identifies that the PD‐associated TMEM175‐L156P variant disrupts lysosomal ion channel trafficking by causing aberrant endoplasmic reticulum retention. A “chaperone–agonist” bifunctional small molecule restores TMEM175‐L156P lysosomal localization and channel function, thereby alleviating PD‐relevant cellular phenotypes and highlighting a ...
Ting Luo, Yu He, Shuyao Li, Haoyu Guan, Ruili Cui, Yu Shi, Zhongwen Jiang, Siyu Wang, Xuan Li, Jiyuan Li, Mei Hu, Yupeng Zhou, Beisha Tang, Yanyan Zhang, Zhaobing Gao, Yu Zhou, Zhenhua Liu, Ping Li   +17 more
wiley   +1 more source

Aggregatibacter actinomycetemcomitans Cytolethal Distending Toxin Induces Cellugyrin-(Synaptogyrin 2) Dependent Cellular Senescence in Oral Keratinocytes

Pathogens
Recently, we reported that oral-epithelial cells (OE) are unique in their response to Aggregatibacter actinomycetemcomitans cytolethal distending toxin (Cdt) in that cell cycle arrest (G2/M) occurs without leading to apoptosis.
Bruce J. Shenker, Jonathan Korostoff, Lisa P. Walker, Ali Zekavat, Anuradha Dhingra, Taewan J. Kim, Kathleen Boesze-Battaglia   +6 more
doaj   +1 more source

Control of the senescence-associated secretory phenotype by NF-kappaB promotes senescence and enhances chemosensitivity [PDF]

, 2011
Cellular senescence acts as a potent barrier to tumorigenesis and contributes to the anti-tumor activity of certain chemotherapeutic agents. Senescent cells undergo a stable cell cycle arrest controlled by RB and p53 and, in addition, display a ...
Wang, X., Premsrirut, P., Bolden, J. E., Chicas, A., Xiaowo Wang, Lowe, S. W., Claudio Scuoppo, Prem Premsrirut, Weijun Luo, Agustin Chicas, Luo, W., Lee, C. S., Xueping Fang, Yuchen Chien, Jessica E. Bolden, Cheng S. Lee, Balgley, B., Chien, Y., Kogan, S. C., Scott C. Kogan, Scott W. Lowe, Brian Balgley, Fang, X., Scuoppo, C.   +23 more
core   +1 more source

A Blood‐Derived Factor Rescues ALS: Platelet Factor 4 Activates OPTN‐Dependent Autophagy to Clear SOD1 Aggregates Independently of PINK1

Advanced Science, EarlyView.
Systemic platelet factor 4 (PF4) is significantly depleted in amyotrophic lateral sclerosis (ALS). Peripheral PF4 replenishment restores central proteostasis by driving OPTN‐dependent, PINK1‐independent selective autophagy in motor neurons. This intervention effectively clears toxic SOD1 aggregates, blunts glial activation, and preserves neuromuscular ...
Qingjian Xie, Yanbo Zhu, Wenhua Jiang, Haobo Xie, Yaojia Li, Mengjie Hu, Kezheng Li, Huan Yu, Yixuan Pan, Chaoyi Jiang, Xueqin Song, Dongsheng Fan, Binbin Deng   +12 more
wiley   +1 more source

Research Progress on the Regulation Mechanism of Senescence-associated Secretory Phenotype in Osteoporosis [PDF]

Zhongguo quanke yixue
Senescence-associated secretory phenotype (SASP) is an important feature of cellular senescence and plays an important role in regulating the disease microenvironment.
YANG Chaofu, TAN Guoqing, XU Zhanwang
doaj   +1 more source

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

JUN mediates the senescence associated secretory phenotype and immune cell recruitment to prevent prostate cancer progression [PDF]

Background: Prostate cancer develops through malignant transformation of the prostate epithelium in a stepwise, mutation-driven process. Although activator protein-1 transcription factors such as JUN have been implicated as potential oncogenic drivers ...
Tichy, Boris, Stoiber, S., Aufinger, Astrid,, Sternberg, Christina, Tichy, B., Sternberg, C., Hoegler, Sandra, Theurillat, Jean-Philippe,, Tichy, Boris,, Högler, Sandra, Tomberger, Martina,, Moriggl, Richard,, Redmer, T., Schlederer, M., Lindner, Desiree, Redmer, Torben, Ziegler, R., Bolis, Marco,, Kodajova, Petra, Oberhuber, Monika, Harbusch, Nora S.,, Sternberg, Christina,, Persson, Jenny L., Neubauer, Heidi A, Merkel, Olaf, Pospisilova, Sarka, Ziegler, Roman,, Oberhuber, Monika,, Sternberg, Felix,, Neubauer, Heidi A.,, Kodajova, Petra,, Bystry, Vojtech, Ziegler, Roman, Lagger, Sabine,, Garces de Los Fayos Alonso, I., Lindner, Desiree,, Mathas, Stephan, Moriggl, R., Theurillat, J.P., Strobl, Birgit, Garces de los Fayos Alonso, Ines,, Persson, Jenny L.,, Stoiber, Stefan, Högler, S., Högler, Sandra,, Merkel, O., Pospisilova, Sarka,, Theurillat, Jean-Philippe, Harbusch, Nora S., Bolis, M., Raigel, Martin,, Lindner, D., Garces de los Fayos Alonso, Ines, Mathas, S., Mathas, Stephan,, Limberger, Tanja, Tomberger, M., Persson, J.L., Schlederer, Michaela, Oberhuber, M., Harbusch, Nora S, Miranda, Sara,, Moriggl, Richard, Pospisilova, S., Persson, Jenny L, Kodajova, P., Aufinger, A., Probst, C., Sternberg, F., Aufinger, Astrid, Miranda, Sara, Stoiber, Stefan,, Strobl, Birgit,, Strobl, B., Sternberg, Felix, Probst, Clara,, Bystry, Vojtech,, Redmer, Torben,, Aberger, F., Egger, Gerda,, Trachtova, Karolina,, Limberger, Tanja,, Harbusch, N.S., Bolis, Marco, Lagger, Sabine, Egger, Gerda, Raigel, M., Kenner, L., Aberger, Fritz, Trachtova, K., Neubauer, H.A., Aberger, Fritz,, Bystry, V., Egger, G., Raigel, Martin, Kenner, Lukas,, Probst, Clara, Tomberger, Martina, Schlederer, Michaela,, Neubauer, Heidi A., Lagger, S., Kenner, Lukas, Miranda, S., Merkel, Olaf,, Trachtova, Karolina, Limberger, T.   +105 more
core   +2 more sources

YAP1‐Driven Pathogenic Fibro‐Adipogenic Progenitors Secrete IL‐6 and FGF21 to Mediate Muscle‐Bone Crosstalk and Promote Bone Loss

Advanced Science, EarlyView.
Fibro‐adipogenic progenitors (FAPs) in atrophic muscle undergo YAP1‐driven pathogenic activation, secreting IL‐6 and FGF21 as bone‐catabolic myokines that mediate muscle‐bone crosstalk and promote bone loss. Genetic or pharmacological targeting of this YAP1‐FAP‐myokine axis rescues skeletal deterioration, identifying FAP‐derived myokines as therapeutic
Xiaoyu Cai, Tao Xu, Rui Ma, Weikun Meng, Shutao Gao, Yakefu Abulizi, Alafate Kahaer, Chuanhui Xun, Maierdan Maimaiti, Rui Cao, Weidong Liang, Polati Maimaiti, Qiang Deng, Jun Sheng, Ting Wang, Mingchong Liu, Weibin Sheng   +16 more
wiley   +1 more source

Inflammasome activation and accelerated immune aging in autoimmune disorders

Frontiers in Aging
Autoimmune diseases, particularly those with early onset such as systemic lupus erythematosus, juvenile idiopathic arthritis, and type 1 diabetes, are paradoxically characterized by molecular and cellular features typically associated with aging.
Rahul Mittal, Rahul Mittal, Danay Saavedra, Mannat Mittal, Joana R. N. Lemos, Joana R. N. Lemos, Khemraj Hirani, Khemraj Hirani   +7 more
doaj   +1 more source