Results 61 to 70 of about 8,472,955 (236)

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

The Regulation of Cellular Senescence in Cancer

Biomolecules
Cellular senescence is a stable state of cell cycle arrest caused by telomere shortening or various stresses. After senescence, cells cease dividing and exhibit many age-related characteristics. Unlike the halted proliferation of senescence cells, cancer
Xianhong Zhang, Yue Gao, Siyu Zhang, Yixiong Wang, Yitian Du, Shuailin Hao, Ting Ni   +6 more
doaj   +1 more source

Dissecting Aging and Senescence—Current Concepts and Open Lessons

Cells, 2019
In contrast to the programmed nature of development, it is still a matter of debate whether aging is an adaptive and regulated process, or merely a consequence arising from a stochastic accumulation of harmful events that culminate in a global state of ...
Christian Schmeer, Alexandra Kretz, Diane Wengerodt, Milan Stojiljkovic, Otto W. Witte   +4 more
doaj   +1 more source

Targeting the Senescence-Associated Secretory Phenotype

, 2019
Age is the single-most significant variable in the loss of normal tissue homeostasis resulting in degenerative disease. Increasing with age is a slight, but significant rise in pro-inflammatory factors in the absence of detectable infection, also known ...
Perrott, Kevin M
core   +1 more source

Microfluidic Nano‐Assembly of Red‐Blood‐Cell (RBC) Lipids and Components for Engineering Extracellular Vesicles

Advanced Healthcare Materials, EarlyView.
Engineered red blood cell‐derived extracellular vesicles (eRBCEVs) are synthesized via controlled microfluidic assembly from native RBC lipids, enabling tunable encapsulation of proteins, nucleic acids, nanoparticles, and viral vectors. The platform demonstrates reproducible nanoscale architecture, preserved membrane composition, and functional cargo ...
Chiranth K. Nagaraj, Xilal Y. Rima, Kim T. Nguyen, Courtney Culkins, Nana Boateng, Jacob Doon‐Ralls, Alejandro Bresolin, Xin Huang, Hong Li, Vahedi Amid, Ajeet Pal Singh, Dharti Shantaram, Anastasiia Amari, Mangesh D. Hade, Nicholas R. Merriam, Zachary D. Schultz, Scott Q. Harper, Nizar Y. Saad, Setty M. Magaña, Willa A. Hsueh, Rachel E. Kopec, Blaise R. Kimmel, Andre F. Palmer, Eduardo Reátegui   +23 more
wiley   +1 more source

Coixenolide Enhances Antitumor Immunity of Cytotoxic CD8+ T Cells by Inhibiting S100A8/A9‐CD36 Axis in Obesity‐Associated Pancreatic Adenocarcinoma

Advanced Science, EarlyView.
Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to
Kaidi Chen, Rong Chen, Wei Li, Bin Song, Ruiying Zhang, Lewei Dai, Yuwei Qi, Ruqian Chen, Yifan Xu, Hangbin Li, Jingyi Huang, Fangping Wu, Jianan Peng, Xinyu Wang, Yang Xiong, Chaofeng Mu, Guilin Cheng, Zhaoshen Li, Shanming Ruan, Lei Huang, Mancang Gu   +20 more
wiley   +1 more source

The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype [PDF]

, 2019
Cellular senescence is a stress response program characterized by a robust cell cycle arrest and the induction of a proinflammatory senescence-associated secretory phenotype (SASP) that is triggered through an unknown mechanism.
Boulter, L, Fernández-Duran, Irene, Birch, Jodie, Muir, Morwenna, Millar, FR, Acosta, JC, Muir, Morwenna; id_orcid, Quintanilla, Andrea, Passos, JF, Hari, Priya, Finch, AJ, Passos, João F., Rink, CJ, Millar, Fraser R., Brunton, Valerie G., Brunton, VG, Birch, J, Quintanilla, A, Morton, Jennifer P., Muir, M, Rink, Curtis J., Hari, P, Finch, Andrew J., Acosta, Juan Carlos, Morton, JP, Tarrats, N, Tarrats, Nuria, Boulter, Luke, Fernandez-Duran, I   +28 more
core   +1 more source

COPD-derived fibroblasts secrete higher levels of senescence-associated secretory phenotype proteins. [PDF]

, 2020
COPD-derived fibroblasts have increased cellular senescence. Senescent cell accumulation can induce tissue dysfunction by their senescence-associated secretory phenotype (SASP).
Heijink IH, de Vries M, Woldhuis RR, Oliver BGG, van den Berge M, Timens W, Brandsma C-A   +6 more
core   +1 more source

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

Brief guide to senescence assays using cultured mammalian cells

Molecules and Cells
: Cellular senescence is a crucial biological process associated with organismal aging and many chronic diseases. Here, we present a brief guide to mammalian senescence assays, including the measurement of cell cycle arrest, change in cellular morphology,
Eunseok Kang, Chanhee Kang, Young-Sam Lee, Seung-Jae V. Lee   +3 more
doaj   +1 more source