Results 131 to 140 of about 62,581 (273)

Cellular Senescence as the Causal Nexus of Aging [PDF]

, 2016
In this paper we present cellular senescence as the ultimate driver of the aging process, as a “causal nexus” that bridges microscopic subcellular damage with the phenotypic, macroscopic effect of aging.
Antonei B. Csoka, Evgeny O. Makarev, Naina Bhatia-Dey, Riya R. Kanherkar, Susan E. Stair   +4 more
core   +1 more source

Farnesyltransferase Deficiency in Cardiomyocytes Initiates Senescence and Contributes to Cardiac Fibrosis

Advanced Science, EarlyView.
Lipid overload suppresses SREBF2‐mediated FNTB expression, leading to defective Lamin A maturation and nuclear envelope instability. This nuclear catastrophe triggers a pro‐fibrotic senescence program in cardiomyocytes. Notably, restoring nuclear integrity via AAV9‐based gene therapy effectively attenuates cardiac remodeling, identifying the ...
Yuxiao Chen, Lian Lou, Xuan Zhang, Lin Yan, Qi Zhang, Wen Shi, Jie Ding, Xu Lin, Rong Jiang, Shuo Liu, Thida Sok, Pengli Wang, Yun Mou, Jie Han, Shenjiang Hu, Xiaogang Guo, Jian Yang   +16 more
wiley   +1 more source

p53-sensitive epileptic behavior and inflammation in Ft1 hypomorphic mice [PDF]

, 2018
Epilepsy is a complex clinical condition characterized by repeated spontaneous seizures. Seizures have been linked to multiple drivers including DNA damage accumulation.
Alessandro, Vercelli, Alex Dimitri Bastianelli,, Burla, Romina, Del Giudice, Simona, Di Cunto, Ferdinando, La Torre, Mattia, Marina, Boido, Merigliano, Chiara, Saggio, Isabella, Verni', Fiammetta, Zanetti, Giorgia   +10 more
core   +2 more sources

Single‐Cell Profiling Across Immune Tissues and Organs Reveals Immunosenescence Signatures in Male Rhesus Monkeys

Advanced Science, EarlyView.
Single‐cell profiling across bone marrow, spleen, mesenteric lymph, and blood in rhesus monkeys reveals organ Immunosenescence. GZMB rises with age, particularly in cytotoxic and terminally exhausted CD8+ T cells, and BHLHE40 emerges as a key transcription factor enriched across multiple CD8+ subsets, regulating pro‐inflammatory and exhaustion‐related ...
Shengnan Wang, Zhengna Zhu, Hongju Yang, Yaping Yan, Luyao Ran, Naixue Yang, Yichao Wang, Li Wu, Bing Bai, Weizhi Ji, Wei Si   +10 more
wiley   +1 more source

Targeting SASP with FDA-approved agents: minoxidil and diazoxide as potential senomorphic agents in cancer therapy

Türk Biyokimya Dergisi
Chemotherapy-induced senescent cells are recognized to lead to cancer progression and resistance to treatment by releasing factors associated with the senescence-associated secretory phenotype (SASP).
Simay Demir Yaprak Dilber, Mohammed Ahmed Islam, Tayyar Tugce, Ozdemir Aysun, Ark Mustafa   +4 more
doaj   +1 more source

Aggregatibacter actinomycetemcomitans Cytolethal Distending Toxin Induces Cellugyrin-(Synaptogyrin 2) Dependent Cellular Senescence in Oral Keratinocytes

Pathogens
Recently, we reported that oral-epithelial cells (OE) are unique in their response to Aggregatibacter actinomycetemcomitans cytolethal distending toxin (Cdt) in that cell cycle arrest (G2/M) occurs without leading to apoptosis.
Bruce J. Shenker, Jonathan Korostoff, Lisa P. Walker, Ali Zekavat, Anuradha Dhingra, Taewan J. Kim, Kathleen Boesze-Battaglia   +6 more
doaj   +1 more source

Clearance of senescent decidual cells by uterine natural killer cells in cycling human endometrium [PDF]

, 2017
In cycling human endometrium, menstruation is followed by rapid estrogen-dependent growth. Upon ovulation, progesterone and rising cellular cAMP levels activate the transcription factor Forkhead box O1 (FOXO1) in endometrial stromal cells (EnSCs ...
Acosta, Aird, Al-Sabbagh, Barros, Bradford, Childs, Chowdhury, de Keizer, de Ziegler, Demidenko, Diep, Dimri, Drury, Erlebacher, Evans, Funayama, Gellersen, Groll, Hanna, Hapangama, Iannello, Krizhanovsky, Laws, Lucas, Lucas, Marçais, Matjusaitis, Mosteiro, Murakami, Muñoz-Espín, Paria, Park, Pfaffl, Pohnke, Rajagopalan, Ritschka, Ruifrok, Sadaie, Saeed, Sagiv, Sagiv, Salker, Smith, Takano, Team, van Deursen, Venables, Xiong, Yuan, Zhang, Zhu, Zhu   +51 more
core   +2 more sources

Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC‐Derived Cortical Organoids

Advanced Science, EarlyView.
A new cerebrocortical organoid model using isogenic hiPSCs with familial Alzheimer's mutations recapitulates key AD features, including amyloid‐beta and phospho‐Tau aggregation, neuronal hyperexcitability, and synapse loss. Single‐cell RNA‐seq reveals aberrant pathways in excitatory and inhibitory neurons.
Sergio R. Labra, Jadon Compher, Akhil Prabhavalkar, Mireya Almaraz, Claudia Cedeño Kwong, Christine Baal, Maria Talantova, Nima Dolatabadi, Julian Piña‐Sanz, Yubo Wang, Leonard Yoon, Swagata Ghatak, Zi Gao, Yuting Zhang, Dorit Trudler, Lynee Massey, Wei Lin, Anthony Balistreri, Michael Bula, Nicholas J. Schork, Tony S. Mondala, Steven R. Head, Jeffery W. Kelly, Stuart A. Lipton   +23 more
wiley   +1 more source

Inflammasome activation and accelerated immune aging in autoimmune disorders

Frontiers in Aging
Autoimmune diseases, particularly those with early onset such as systemic lupus erythematosus, juvenile idiopathic arthritis, and type 1 diabetes, are paradoxically characterized by molecular and cellular features typically associated with aging.
Rahul Mittal, Rahul Mittal, Danay Saavedra, Mannat Mittal, Joana R. N. Lemos, Joana R. N. Lemos, Khemraj Hirani, Khemraj Hirani   +7 more
doaj   +1 more source

Branched-Chain Amino Acid Accumulation Fuels the Senescence-Associated Secretory Phenotype. [PDF]

Adv Sci (Weinh), 2023
The essential branched‐chain amino acids (BCAAs) leucine, isoleucine, and valine play critical roles in protein synthesis and energy metabolism. Despite their widespread use as nutritional supplements, BCAAs’ full effects on mammalian physiology remain ...
Liang Y, Pan C, Yin T, Wang L, Gao X, Wang E, Quang H, Huang, Tan L, Xiang K, Wang Y, Alexander PB, Li QJ, Yao TP, Zhang Z, Wang XF.   +15 more
europepmc   +2 more sources