Results 211 to 220 of about 50,933 (296)

Immunoregulatory mechanisms in the aging microenvironment: Targeting the senescence-associated secretory phenotype for cancer immunotherapy. [PDF]

Acta Pharm Sin B
Wang H, Yu Y, Li R, Zhang H, Chen ZS, Sun C, Zhuang J.   +6 more
europepmc   +1 more source

Potential Biomarkers for Disease Stratification and Prognosis Prediction in Pediatric Asthma: LCN2, sST2 and FGF21

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Pediatric asthma is a common chronic airway inflammatory disease, where accurate assessment of disease severity and prognosis prediction is crucial for treatment decisions. Currently, there is a lack of precise and effective biomarkers.
Xu Yang, Hai Wang, Yong‐Zheng Zhang, Yan‐Yan Chen, Xin‐Xin Xing, Yi‐Cheng Ding   +5 more
wiley   +1 more source

Integrative Transcriptomic and Machine Learning Analysis Identifies Key Senescence-Associated Secretory Phenotype Genes Associated With Immune Dysregulation in Periodontitis. [PDF]

Hum Mutat
Zeng J, Huang J, He J, Tan J, Duan M, Song Y, Yang L.   +6 more
europepmc   +1 more source

Natural Killer Subset Changes and Vascular Endothelial Growth Factor‐A Plasma Profile in Progressive Supranuclear Palsy: The NKscape Study

Movement Disorders, EarlyView.
Abstract Background Emerging evidence implicates neuroinflammation in progressive supranuclear palsy (PSP) pathophysiology, with elevated cyto‐chemokines suggesting natural killer (NK) cell involvement. Methods We characterized peripheral NK in PSP (N = 11) versus Parkinson's disease (PD, N = 10) and healthy controls (HC, N = 8) at both ...
Marina Picillo, Cristina Basile, Francesco Montella, Valentina Lopardo, Mariangela Orlando, Roberta Tarallo, Domenico Palumbo, Viola Melone, Maria Francesca Tepedino, Paolo Barone, Annibale Alessandro Puca, Elena Ciaglia   +11 more
wiley   +1 more source

Senescent bone marrow mesenchymal stem cells exacerbate subchondral bone sclerosis and osteoarthritis via the senescence-associated secretory phenotype. [PDF]

Stem Cell Res Ther
Yang D, Xu X, Xu K, Yang M, Hao Y, Aihaiti Y, Li E, Yan Y, Lu C, Xu P.   +9 more
europepmc   +1 more source

What Role Does the Central Nervous System Play in Refractory LUTS, and What Are the Therapeutic Implications? ICI‐RS 2025

Neurourology and Urodynamics, EarlyView.
ABSTRACT Aims While many patients with lower urinary tract symptoms (LUTS) improve by treating peripheral causes, a substantial proportion continue to experience symptoms despite apparently successful interventions. Central nervous system (CNS) mechanisms could potentially contribute to persisting symptoms after the initial peripheral cause has been ...
Mathijs M. de Rijk, Michel Wyndaele, Ana Charrua, Christopher Fry, Paul Abrams, Gommert A. van Koeveringe, Anthony J. Kanai, Marcus J. Drake   +7 more
wiley   +1 more source

Senescence-associated secretory phenotype in lung cancer: remodeling the tumor microenvironment for metastasis and immune suppression. [PDF]

Front Oncol
Chen C, Chen J, Zhang Y, Zhang Q, Shi H.
europepmc   +1 more source

Endoplasmic reticulum stress and the unfolded protein response in lung diseases: molecular pathways and therapeutic interventions

The Journal of Pathology, EarlyView.
Abstract Endoplasmic reticulum stress (ERS) occurs when the protein‐folding capacity of the endoplasmic reticulum (ER) is overwhelmed, triggering the unfolded protein response (UPR) to restore homeostasis. However, severe or persistent ERS can shift the UPR toward pro‐inflammatory, apoptotic, and fibrotic signaling, thereby exacerbating tissue injury ...
Lanlan Song, Yichen Liu, Chen Xu, Yaochen Zhang, Kaiming Xu, Dan Yao, Xiaoying Huang   +6 more
wiley   +1 more source

Senescent-like microglia limit remyelination through the senescence associated secretory phenotype. [PDF]

Nat Commun
Gross PS, Durán-Laforet V, Ho LT, Melchor GS, Zia S, Manavi Z, Barclay WE, Lee SH, Shults N, Selva S, Alvarez E, Plemel JR, Fu MM, Schafer DP, Huang JK.   +14 more
europepmc   +1 more source

Adipose‐derived and bone marrow aspirate concentrate injections for osteoarthritis: A scoping review

PM&R, EarlyView.
Abstract Background Osteoarthritis is a leading cause of disability worldwide, and cell‐based treatments including adipose‐derived and bone marrow aspirate have been sought by the lay and medical community as treatment options. Objective To perform a scoping review of published literature on cell‐based injections allowed by the U.S.
Leonardo P. Oliveira, Aaron Lear, Joseph Elphingstone, Derek Stokes, Rachel Chamberlain, Timothy Tiu, David Price, Megan Agnew, Stephanie Kliethermes, Sarah Sund, Leslie A. Christensen, Shane Shapiro, Kenneth Mautner   +12 more
wiley   +1 more source