Results 221 to 230 of about 32,141 (252)

The senescence-associated secretory phenotype in ovarian cancer dissemination

American Journal of Physiology-Cell Physiology, 2022
Ovarian cancer is a highly aggressive disease with poor survival rates in part due to diagnosis after dissemination throughout the peritoneal cavity. It is well-known that inflammatory signals affect ovarian cancer dissemination. Inflammation is a hallmark of cellular senescence, a stable cell cycle arrest induced by a variety of stimuli including ...
Jacob P. Veenstra, Lucas Felipe Fernandes Bittencourt, Katherine M. Aird   +2 more
openaire   +2 more sources

Pro- and anti-tumorigenic functions of the senescence-associated secretory phenotype

Expert Opinion on Therapeutic Targets, 2019
Introduction: Cellular senescence is a stable form of cell cycle exit. Though they no longer divide, senescent cells remain metabolically active and secrete a plethora of proteins collectively termed the senescence-associated secretory phenotype (SASP).
Gregory David
exaly   +4 more sources

The senescence-associated secretory phenotype and its regulation

Cytokine, 2019
The senescence-associated secretory phenotype (SASP) defines the ability of senescent cells to express and secrete a variety of extracellular modulators that includes cytokines, chemokines, proteases, growth factors and bioactive lipids. The role of the SASP depends on the context.
Stéphane Lopes-Paciencia, Emmanuelle Saint-Germain, Marie-Camille Rowell, Ana Fernández Ruiz, Paloma Kalegari, Gerardo Ferbeyre   +5 more
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The senescence-associated secretory phenotype: Fueling a wound that never heals

Mechanisms of Ageing and Development, 2021
Wound healing is impaired with advanced age and certain chronic conditions, such as diabetes and obesity. Moreover, common cancer treatments, including chemotherapy and radiation, can cause unintended tissue damage and impair wound healing. Available wound care treatments are not always effective, as some wounds fail to heal or recur after treatment ...
Tanya Pulido, Michael C. Velarde, Fatouma Alimirah   +2 more
openaire   +2 more sources

The Senescence-Associated Secretory Phenotype In Multiple Myeloma

Blood, 2013
Abstract Introduction The incidence of multiple myeloma (MM) increases with age, yet some cytogenetic changes are actually more common in younger patients with MM (Avet-Loiseau J Clin Oncol 2013).  This suggests that a mechanism other than chromosomal changes underlies the increased incidence with age.
Tanya M Wildes, Jacob Paasch, Mark A. Fiala, Ling Chen, Ravi Vij, Keith E. Stockerl-Goldstein, Sheila Stewart, Graham A. Colditz, Michael Tomasson   +8 more
openaire   +1 more source

The senescence-associated secretory phenotype and its physiological and pathological implications

Nature Reviews Molecular Cell Biology
Cellular senescence is a state of terminal growth arrest associated with the upregulation of different cell cycle inhibitors, mainly p16 and p21, structural and metabolic alterations, chronic DNA damage responses, and a hypersecretory state known as the senescence-associated secretory phenotype (SASP).
Boshi Wang, Jennifer H Elisseeff, Marco Demaria   +2 more
exaly   +3 more sources

Senescence-associated secretory phenotype contributes to pathological angiogenesis in retinopathy

Science Translational Medicine, 2016
Senescent cells encourage abnormal blood vessels and retinal disease.
Malika, Oubaha, Khalil, Miloudi, Agnieszka, Dejda, Vera, Guber, Gaëlle, Mawambo, Marie-Anne, Germain, Guillaume, Bourdel, Natalija, Popovic, Flavio A, Rezende, Randal J, Kaufman, Frédérick A, Mallette, Przemyslaw, Sapieha   +11 more
openaire   +2 more sources

NLRP1 inflammasome modulates senescence and senescence-associated secretory phenotype

2023
Abstract Senescence is a cellular aging-related process triggered by different stresses and characterized by the secretion of various inflammatory factors referred to as the senescence-associated secretory phenotype (SASP). Here, we present evidence that the inflammasome sensor, NLRP1, is a key mediator of senescence induced by ...
Ines, Muela-Zarzuela, Juan M, Suarez-Rivero, Andrea, Gallardo-Orihuela, Chun, Wang, Kumi, Izawa, Marta, de Gregorio-Procopio, Isabelle, Couillin, Bernhard, Ryffel, Jiro, Kitaura, Alberto, Sanz, Thomas, von Zglinicki, Gabriel, Mbalaviele, Mario D, Cordero   +12 more
openaire   +2 more sources

Detection of the Senescence-Associated Secretory Phenotype (SASP)

2012
Cellular senescence suppresses cancer by eliminating potentially oncogenic cells, participates in tissue repair, contributes to cancer therapy, and promotes organismal aging. Numerous activities of senescent cells depend on the aptitude of these cells to secrete myriads of bioactive molecules, a behavior termed the senescence-associated secretory ...
openaire   +2 more sources

Targeting the Senescence-Associated Secretory Phenotype

2019
Age is the single-most significant variable in the loss of normal tissue homeostasis resulting in degenerative disease. Increasing with age is a slight, but significant rise in pro-inflammatory factors in the absence of detectable infection, also known as “sterile inflammation”.
openaire   +1 more source