Results 251 to 260 of about 8,472,936 (269)

The senescence-associated secretory phenotype and its physiological and pathological implications

Nature Reviews Molecular Cell Biology
Cellular senescence is a state of terminal growth arrest associated with the upregulation of different cell cycle inhibitors, mainly p16 and p21, structural and metabolic alterations, chronic DNA damage responses, and a hypersecretory state known as the senescence-associated secretory phenotype (SASP).
Jin Han, Jennifer Elisseeff, Marco Demaria   +2 more
exaly   +3 more sources

Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype [PDF]

Cell Metabolism, 2016
Cellular senescence permanently arrests cell proliferation, often accompanied by a multi-faceted senescence-associated secretory phenotype (SASP). Loss of mitochondrial function can drive age-related declines in the function of many post-mitotic tissues,
Judith Campisi, Arvind Ramanathan, Christopher D Wiley   +2 more
exaly   +2 more sources

Senescence-associated secretory phenotype contributes to pathological angiogenesis in retinopathy

Science Translational Medicine, 2016
Senescent cells encourage abnormal blood vessels and retinal disease.
Malika, Oubaha, Khalil, Miloudi, Agnieszka, Dejda, Vera, Guber, Gaëlle, Mawambo, Marie-Anne, Germain, Guillaume, Bourdel, Natalija, Popovic, Flavio A, Rezende, Randal J, Kaufman, Frédérick A, Mallette, Przemyslaw, Sapieha   +11 more
openaire   +2 more sources

NLRP1 inflammasome modulates senescence and senescence-associated secretory phenotype

2023
Abstract Senescence is a cellular aging-related process triggered by different stresses and characterized by the secretion of various inflammatory factors referred to as the senescence-associated secretory phenotype (SASP). Here, we present evidence that the inflammasome sensor, NLRP1, is a key mediator of senescence induced by ...
Ines, Muela-Zarzuela, Juan M, Suarez-Rivero, Andrea, Gallardo-Orihuela, Chun, Wang, Kumi, Izawa, Marta, de Gregorio-Procopio, Isabelle, Couillin, Bernhard, Ryffel, Jiro, Kitaura, Alberto, Sanz, Thomas, von Zglinicki, Gabriel, Mbalaviele, Mario D, Cordero   +12 more
openaire   +2 more sources

Detection of the Senescence-Associated Secretory Phenotype (SASP)

2012
Cellular senescence suppresses cancer by eliminating potentially oncogenic cells, participates in tissue repair, contributes to cancer therapy, and promotes organismal aging. Numerous activities of senescent cells depend on the aptitude of these cells to secrete myriads of bioactive molecules, a behavior termed the senescence-associated secretory ...
openaire   +2 more sources

Ginsenoside F1 suppresses astrocytic senescence-associated secretory phenotype

Chemico-Biological Interactions, 2018
Senescence is one of the hallmarks of aging and identified as a potential therapeutic target in the treatment of aging and aging-related diseases. Senescent cells accumulate with age in a variety of human tissues where they develop a complex senescence-associated secretory phenotype (SASP). SASP in brain could contribute to age-related inflammation and
Jingang, Hou, Changhao, Cui, Sunchang, Kim, Changkeun, Sung, Chulhee, Choi   +4 more
openaire   +2 more sources

Assessing Functional Roles of the Senescence-Associated Secretory Phenotype (SASP)

2018
Cellular senescence is linked to many normal biological processes, including tumor suppression, development, and wound healing, but it is also associated with age-related pathologies such as cancer progression. Numerous functions of senescent cells depend on their ability to secrete bioactive molecules, a characteristic termed the senescence-associated
Nicolas, Malaquin, Véronique, Tu, Francis, Rodier   +2 more
openaire   +2 more sources

Targeting the senescence-associated secretory phenotype to modify osteoarthritis in aging

Inflammopharmacology
Osteoarthritis (OA) is a common joint condition correlated with aging, characterized by the gradual degradation of cartilage, alterations in the subchondral bone, and ongoing low-level inflammation. There is growing evidence that the senescence-associated secretory phenotype (SASP) of chondrocytes, which includes the continuous release of IL1β, IL6 ...
Muhammad Afzal, M. M. Rekha, Samir Sahoo, Surya Nath Pandey, Chandana Maji, Kavita Goyal, Haider Ali, Sachin Kumar Singh, Gaurav Gupta, Md Sadique Hussain   +9 more
openaire   +2 more sources

Dynamic and scalable assessment of the senescence-associated secretory phenotype (SASP)

Dual-faced cellular senescence is responsible for beneficial biological processes and for age-related pathologies. Senescent cells under stable proliferation arrest develop numerous senescence-associated phenotypes such as the potent pro-inflammatory secretome called the senescence-associated secretory phenotype (SASP).
Nicolas, Malaquin, Francis, Rodier
openaire   +2 more sources

Regulation of the senescence-associated secretory phenotype by the nucleoporin TPR

2022
Trabajo presentado en el yICSA Senescence Symposium, celebrado en Londres (Inglaterra) el 29 de abril de 2022.
Bartlett, Bethany, Kumar, Yatendra, Boumendil, Charlene, Acosta, Juan C., Bickmore, Wendy   +4 more
openaire   +1 more source