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Mitochondrial injury induced by a Salmonella genotoxin triggers the proinflammatory senescence-associated secretory phenotype. [PDF]
Nat CommunChen HY +14 more
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Targeting the senescence-associated secretory phenotype in cancer therapy
, 2023 openaire +1 more source
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Chromatin basis of the senescence-associated secretory phenotype
Trends in Cell Biology, 2022Cellular senescence is a stable cell growth arrest. Senescent cells are metabolically active, as exemplified by the secretion of inflammatory cytokines, chemokines, and growth factors, which is termed senescence-associated secretory phenotype (SASP).
Xue, Hao, Chen, Wang, Rugang, Zhang
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The senescence-associated secretory phenotype and its physiological and pathological implications
Nature Reviews Molecular Cell BiologyCellular senescence is a state of terminal growth arrest associated with the upregulation of different cell cycle inhibitors, mainly p16 and p21, structural and metabolic alterations, chronic DNA damage responses, and a hypersecretory state known as the senescence-associated secretory phenotype (SASP).
Boshi Wang +3 more
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Controlling the senescence-associated secretory phenotype
Nature Reviews Molecular Cell Biology, 2016openaire +3 more sources
The senescence-associated secretory phenotype in ovarian cancer dissemination
American Journal of Physiology-Cell Physiology, 2022Ovarian cancer is a highly aggressive disease with poor survival rates in part due to diagnosis after dissemination throughout the peritoneal cavity. It is well-known that inflammatory signals affect ovarian cancer dissemination. Inflammation is a hallmark of cellular senescence, a stable cell cycle arrest induced by a variety of stimuli including ...
Jacob P. Veenstra +2 more
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