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Correction to: Prognostic Significance and Biologic Associations of Senescence-Associated Secretory Phenotype Biomarkers in Heart Failure. [PDF]
J Am Heart Assoceuropepmc +1 more source
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Chromatin basis of the senescence-associated secretory phenotype
Trends in Cell Biology, 2022Cellular senescence is a stable cell growth arrest. Senescent cells are metabolically active, as exemplified by the secretion of inflammatory cytokines, chemokines, and growth factors, which is termed senescence-associated secretory phenotype (SASP).
Rugang Zhang, Xuexue Hao
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The senescence-associated secretory phenotype in ovarian cancer dissemination
American Journal of Physiology-Cell Physiology, 2022Ovarian cancer is a highly aggressive disease with poor survival rates in part due to diagnosis after dissemination throughout the peritoneal cavity. It is well-known that inflammatory signals affect ovarian cancer dissemination. Inflammation is a hallmark of cellular senescence, a stable cell cycle arrest induced by a variety of stimuli including ...
Jacob P. Veenstra +2 more
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The senescence-associated secretory phenotype and its regulation
Cytokine, 2019The senescence-associated secretory phenotype (SASP) defines the ability of senescent cells to express and secrete a variety of extracellular modulators that includes cytokines, chemokines, proteases, growth factors and bioactive lipids. The role of the SASP depends on the context.
Stéphane Lopes-Paciencia +5 more
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The senescence-associated secretory phenotype: Fueling a wound that never heals
Mechanisms of Ageing and Development, 2021Wound healing is impaired with advanced age and certain chronic conditions, such as diabetes and obesity. Moreover, common cancer treatments, including chemotherapy and radiation, can cause unintended tissue damage and impair wound healing. Available wound care treatments are not always effective, as some wounds fail to heal or recur after treatment ...
Tanya Pulido +2 more
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The Senescence-Associated Secretory Phenotype In Multiple Myeloma
Blood, 2013Abstract Introduction The incidence of multiple myeloma (MM) increases with age, yet some cytogenetic changes are actually more common in younger patients with MM (Avet-Loiseau J Clin Oncol 2013). This suggests that a mechanism other than chromosomal changes underlies the increased incidence with age.
Tanya M Wildes +8 more
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