Results 231 to 240 of about 32,141 (252)

Ginsenoside F1 suppresses astrocytic senescence-associated secretory phenotype

Chemico-Biological Interactions, 2018
Senescence is one of the hallmarks of aging and identified as a potential therapeutic target in the treatment of aging and aging-related diseases. Senescent cells accumulate with age in a variety of human tissues where they develop a complex senescence-associated secretory phenotype (SASP). SASP in brain could contribute to age-related inflammation and
Jingang, Hou, Changhao, Cui, Sunchang, Kim, Changkeun, Sung, Chulhee, Choi   +4 more
openaire   +2 more sources

Assessing Functional Roles of the Senescence-Associated Secretory Phenotype (SASP)

2018
Cellular senescence is linked to many normal biological processes, including tumor suppression, development, and wound healing, but it is also associated with age-related pathologies such as cancer progression. Numerous functions of senescent cells depend on their ability to secrete bioactive molecules, a characteristic termed the senescence-associated
Nicolas, Malaquin, Véronique, Tu, Francis, Rodier   +2 more
openaire   +2 more sources

Targeting the senescence-associated secretory phenotype to modify osteoarthritis in aging

Inflammopharmacology
Osteoarthritis (OA) is a common joint condition correlated with aging, characterized by the gradual degradation of cartilage, alterations in the subchondral bone, and ongoing low-level inflammation. There is growing evidence that the senescence-associated secretory phenotype (SASP) of chondrocytes, which includes the continuous release of IL1β, IL6 ...
Muhammad Afzal, M. M. Rekha, Samir Sahoo, Surya Nath Pandey, Chandana Maji, Kavita Goyal, Haider Ali, Sachin Kumar Singh, Gaurav Gupta, Md Sadique Hussain   +9 more
openaire   +2 more sources

Dynamic and scalable assessment of the senescence-associated secretory phenotype (SASP)

Dual-faced cellular senescence is responsible for beneficial biological processes and for age-related pathologies. Senescent cells under stable proliferation arrest develop numerous senescence-associated phenotypes such as the potent pro-inflammatory secretome called the senescence-associated secretory phenotype (SASP).
Nicolas, Malaquin, Francis, Rodier
openaire   +2 more sources

Regulation of the senescence-associated secretory phenotype by the nucleoporin TPR

2022
Trabajo presentado en el yICSA Senescence Symposium, celebrado en Londres (Inglaterra) el 29 de abril de 2022.
Bartlett, Bethany, Kumar, Yatendra, Boumendil, Charlene, Acosta, Juan C., Bickmore, Wendy   +4 more
openaire   +1 more source

Fusobacterium nucleatum promotes esophageal squamous cell carcinoma progression and chemoresistance by enhancing the secretion of chemotherapy-induced senescence-associated secretory phenotype via activation of DNA damage response pathway

Gut Microbes, 2023
Jingping Yuan, Baoping Yu
exaly  

Regulation of the Pro-Tumorigenic Senescence-Associated Secretory Phenotype

2017
Tumorigenesis results from the convergence of cell autonomous mutations and corresponding stromal changes that promote tumor cell growth. Mutations and stromal changes both accumulate with age and together account for the dramatic increase in cancer incidence with age.
openaire   +2 more sources

Inflammation-driven senescence-associated secretory phenotype in cancer-associated fibroblasts enhances peritoneal dissemination

Cell Reports, 2021
Tadahito Yasuda, Ryusho Kariya, Sho Kubota   +2 more
exaly  

Cellular senescence and the senescence-associated secretory phenotype: Potential therapeutic targets for renal fibrosis

Experimental Gerontology, 2021
Xiang-Mei Chen, Guangyan Cai
exaly  

Senescence-associated extracellular vesicle release plays a role in senescence-associated secretory phenotype (SASP) in age-associated diseases

Journal of Biochemistry, 2021
Yoko Tanaka, Akiko Takahashi, Takahashi Akiko   +2 more
exaly