Results 221 to 230 of about 30,050 (236)

The senescence-associated secretory phenotype and its regulation

Cytokine, 2019
The senescence-associated secretory phenotype (SASP) defines the ability of senescent cells to express and secrete a variety of extracellular modulators that includes cytokines, chemokines, proteases, growth factors and bioactive lipids. The role of the SASP depends on the context.
Stéphane Lopes-Paciencia, Emmanuelle Saint-Germain, Marie-Camille Rowell, Ana Fernández Ruiz, Paloma Kalegari, Gerardo Ferbeyre   +5 more
openaire   +2 more sources

Ginsenoside F1 suppresses astrocytic senescence-associated secretory phenotype

Chemico-Biological Interactions, 2018
Senescence is one of the hallmarks of aging and identified as a potential therapeutic target in the treatment of aging and aging-related diseases. Senescent cells accumulate with age in a variety of human tissues where they develop a complex senescence-associated secretory phenotype (SASP). SASP in brain could contribute to age-related inflammation and
Jingang, Hou, Changhao, Cui, Sunchang, Kim, Changkeun, Sung, Chulhee, Choi   +4 more
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NLRP1 inflammasome modulates senescence and senescence-associated secretory phenotype

2023
AbstractSenescence is a cellular aging-related process triggered by different stresses and characterized by the secretion of various inflammatory factors referred to as the senescence-associated secretory phenotype (SASP). Here, we present evidence that the inflammasome sensor, NLRP1, is a key mediator of senescence induced by irradiation both in vitro
Ines, Muela-Zarzuela, Juan M, Suarez-Rivero, Andrea, Gallardo-Orihuela, Chun, Wang, Kumi, Izawa, Marta, de Gregorio-Procopio, Isabelle, Couillin, Bernhard, Ryffel, Jiro, Kitaura, Alberto, Sanz, Thomas, von Zglinicki, Gabriel, Mbalaviele, Mario D, Cordero   +12 more
openaire   +2 more sources

The Senescence-Associated Secretory Phenotype In Multiple Myeloma

Blood, 2013
Abstract Introduction The incidence of multiple myeloma (MM) increases with age, yet some cytogenetic changes are actually more common in younger patients with MM (Avet-Loiseau J Clin Oncol 2013).  This suggests that a mechanism other than chromosomal changes underlies the increased incidence with age.
Tanya M Wildes, Jacob Paasch, Mark A. Fiala, Ling Chen, Ravi Vij, Keith E. Stockerl-Goldstein, Sheila Stewart, Graham A. Colditz, Michael Tomasson   +8 more
openaire   +1 more source

Targeting the Senescence-Associated Secretory Phenotype

2019
Age is the single-most significant variable in the loss of normal tissue homeostasis resulting in degenerative disease. Increasing with age is a slight, but significant rise in pro-inflammatory factors in the absence of detectable infection, also known as “sterile inflammation”.
openaire   +1 more source

Senescence-associated secretory phenotype contributes to pathological angiogenesis in retinopathy

Science Translational Medicine, 2016
Senescent cells encourage abnormal blood vessels and retinal disease.
Malika, Oubaha, Khalil, Miloudi, Agnieszka, Dejda, Vera, Guber, Gaëlle, Mawambo, Marie-Anne, Germain, Guillaume, Bourdel, Natalija, Popovic, Flavio A, Rezende, Randal J, Kaufman, Frédérick A, Mallette, Przemyslaw, Sapieha   +11 more
openaire   +2 more sources

Detection of the Senescence-Associated Secretory Phenotype (SASP)

2012
Cellular senescence suppresses cancer by eliminating potentially oncogenic cells, participates in tissue repair, contributes to cancer therapy, and promotes organismal aging. Numerous activities of senescent cells depend on the aptitude of these cells to secrete myriads of bioactive molecules, a behavior termed the senescence-associated secretory ...
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Assessing Functional Roles of the Senescence-Associated Secretory Phenotype (SASP)

2018
Cellular senescence is linked to many normal biological processes, including tumor suppression, development, and wound healing, but it is also associated with age-related pathologies such as cancer progression. Numerous functions of senescent cells depend on their ability to secrete bioactive molecules, a characteristic termed the senescence-associated
Nicolas, Malaquin, Véronique, Tu, Francis, Rodier   +2 more
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CNPY2 modulates senescence-associated secretory phenotype in tendon stem/progenitor cells

Tissue and Cell
Age-related diseases are often linked to chronic inflammation. Senescent cells secrete inflammatory cytokines, chemokines and matrix metalloproteinases, collectively referred to as the senescence-associated secretory phenotype (SASP). The current study discovered that aging leads to the accumulation of senescent tendon stem/progenitor cells (TSPCs) in ...
Gang Xu, Youhua Wang
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The senescence-associated secretory phenotype and its physiological and pathological implications

Nature Reviews Molecular Cell Biology
Cellular senescence is a state of terminal growth arrest associated with the upregulation of different cell cycle inhibitors, mainly p16 and p21, structural and metabolic alterations, chronic DNA damage responses, and a hypersecretory state known as the senescence-associated secretory phenotype (SASP).
Boshi Wang, Jin Han, Jennifer H. Elisseeff, Marco Demaria   +3 more
openaire   +2 more sources