Results 1 to 10 of about 26,014 (255)

The roles and mechanisms of senescence-associated secretory phenotype (SASP): can it be controlled by senolysis? [PDF]

Inflammation and Regeneration, 2022
Cellular senescence is a state of irreversible cell cycle arrest that can be induced by a variety of potentially oncogenic stimuli, including DNA damage.
Naoko Ohtani
doaj   +5 more sources

Senescent Endothelial Cells Sustain Their Senescence-Associated Secretory Phenotype (SASP) through Enhanced Fatty Acid Oxidation [PDF]

Antioxidants (Basel), 2023
Cellular senescence is closely linked to endothelial dysfunction, a key factor in age-related vascular diseases. Senescent endothelial cells exhibit a proinflammatory phenotype known as SASP, leading to chronic inflammation (inflammaging) and vascular ...
Giuliani A, Giudetti A, Vergara D, Del Coco L, Ramini D, Caccese S, Sbriscia M, Graciotti L, Fulgenzi G, Tiano L, Fanizzi F, Olivieri F, Rippo M, Sabbatinelli J.   +13 more
europepmc   +5 more sources

Overcoming the senescence-associated secretory phenotype (SASP): a complex mechanism of resistance in the treatment of cancer. [PDF]

Mol Oncol, 2021
Senescence is a cellular state in which cells undergo persistent cell cycle arrest in response to nonlethal stress. In the treatment of cancer, senescence induction is a potent method of suppressing tumour cell proliferation.
Chambers CR, Ritchie S, Pereira BA, Timpson P.   +3 more
europepmc   +6 more sources

ROCK inhibition modulates the senescence-associated secretory phenotype (SASP) in oral keratinocytes. [PDF]

FEBS Open Bio, 2020
Senescent cells accumulate in different organs and develop a senescence‐associated secretory phenotype (SASP), associated with the development of age‐related pathologies.
Niklander S, Bandaru D, Lambert DW, Hunter KD.   +3 more
europepmc   +6 more sources

The controversial role of senescence-associated secretory phenotype (SASP) in cancer therapy. [PDF]

Mol Cancer
Cellular senescence, characterized by partially irreversible cell cycle arrest, has a dual role in cancer progression via the senescence-associated secretory phenotype (SASP).
Cao L, Li K, Li Q, Tong Q, Wang Y, Huang L.   +5 more
europepmc   +3 more sources

The Senescence-Associated Secretory Phenotype (SASP) in the Challenging Future of Cancer Therapy and Age-Related Diseases. [PDF]

Biology (Basel), 2020
Simple Summary A fundamental feature of cellular senescence is the emergence of the Senescence-Associated Secretory Phenotype (SASP), which represents a considerable source of inflammatory and tissue-remodeling cues.
Cuollo L, Antonangeli F, Santoni A, Soriani A.   +3 more
europepmc   +9 more sources

The microRNA-34a-Induced Senescence-Associated Secretory Phenotype (SASP) Favors Vascular Smooth Muscle Cells Calcification. [PDF]

Int J Mol Sci, 2020
The senescence of vascular smooth muscle cells (VSMCs), characterized by the acquisition of senescence-associated secretory phenotype (SASP), is relevant for VSMCs osteoblastic differentiation and vascular calcification (VC).
Zuccolo E, Badi I, Scavello F, Gambuzza I, Mancinelli L, Macrì F, Tedesco CC, Veglia F, Bonfigli AR, Olivieri F, Raucci A.   +10 more
europepmc   +5 more sources

Unique Human and Mouse β-Cell Senescence-Associated Secretory Phenotype (SASP) Reveal Conserved Signaling Pathways and Heterogeneous Factors. [PDF]

Diabetes, 2021
The aging of pancreatic β-cells may undermine their ability to compensate for insulin resistance, leading to the development of type 2 diabetes (T2D).
Midha A, Pan H, Abarca C, Andle J, Carapeto P, Bonner-Weir S, Aguayo-Mazzucato C.   +6 more
europepmc   +5 more sources

Single-cell transcriptomics identifies senescence-associated secretory phenotype (SASP) features of testicular aging in human. [PDF]

Aging (Albany NY)
The male reproductive system experiences degradation with age, predominantly impacting the testes. Testicular aging can result in failure to produce physiological testosterone levels, normal sperm concentrations, or both.
He J, Li J, Li Y, Xu Z, Ma M, Chen H, Chen P, Lv L, Shang X, Liu G.   +9 more
europepmc   +4 more sources

IGFBP7 is a key component of the senescence-associated secretory phenotype (SASP) that induces senescence in healthy cells by modulating the insulin, IGF, and activin A pathways. [PDF]

Cell Commun Signal
Senescent cells exert their effects through the release of various factors, collectively referred to as the senescence-associated secretory phenotype (SASP).
Siraj Y, Aprile D, Alessio N, Peluso G, Di Bernardo G, Galderisi U.   +5 more
europepmc   +2 more sources