Ageing Through the Looking‐Glass: The Different Flavours of Clonal Haematopoiesis
Aging Cell, Volume 25, Issue 3, March 2026.Different forms of CH share common germline and environmental risk factors and have overlapping prevalence and disease associations, suggesting common underlying ageing processes. We explore intersections of different forms of CH, clinical implications of these, and how this enhances our understanding of the biology of ageing.
Jasmine Singh +4 more
wiley +1 more source
The Impact of Senescence-Associated Secretory Phenotype (SASP) on Head and Neck Cancers: From Biology to Therapy. [PDF]
Cancers (Basel)Alam MT +8 more
europepmc +1 more source
DNA Methylation Signatures of Cellular Senescence Are Not Reversed by Senolytic Treatment
Aging Cell, Volume 25, Issue 3, March 2026.We found very little overlap between CpGs that were correlated with in vitro senescence, chronological age, and mortality. While we were able to train epigenetic clocks with CpGs that accelerated with cellular senescence, these clocks did not decelerate with Senolytic treatment. ABSTRACT Epigenetic clocks are commonly used aging biomarkers based on DNA
Jessica Kasamoto +7 more
wiley +1 more source
Aging Cell, Volume 25, Issue 3, March 2026.By a global proteomic profiling of senescent human BJ fibroblasts induced by ionizing radiation, key cellular features required for the survival of senescent fibroblasts were revealed, and pyruvate dehydrogenase was demonstrated as a potent senolytic target for selectively eliminating senescent normal cells, particularly the therapy‐induced senescent ...
Mingzhu Zhang +13 more
wiley +1 more source
Inhibition of the metalloprotease ADAM19 as a novel senomorphic strategy to ameliorate gut permeability and senescence markers by modulating senescence-associated secretory phenotype (SASP). [PDF]
Aging (Albany NY)Bar S +10 more
europepmc +1 more source
Aging Cell, Volume 25, Issue 3, March 2026.Aging is associated with a senescent‐like phenotype in neutrophils that emerges in bone marrow cells; however, many facets of this phenotype are only fully acquired upon entry into peripheral tissues. This neutrophil senescent‐like phenotype is in part driven by TNFα and impairs resistance of aged hosts to S. pneumoniae. Created in BioRender. Boughanem
Michael C. Battaglia +13 more
wiley +1 more source
A Senolytic Strategy for Metabolic Health: Why the Endothelium Matters
iNew Medicine, Volume 2, Issue 1, March 2026.
He Liang +3 more
wiley +1 more source
Aging Cell, Volume 25, Issue 3, March 2026.Cardiac aging promotes mitochondrial AGE accumulation driven by defective glycative stress detoxification. AGE‐modified mitochondria disrupt lysosomal proteolysis, impairing mitophagy and promoting lipofuscin buildup. This mechanism sustains chronic unresolved mitochondrial damage, driving proinflammatory senescence in cardiomyocytes and defining a ...
Diana Bou‐Teen +13 more
wiley +1 more source
Correction to: Optimisation of a screening platform for determining IL-6 inflammatory signalling in the senescence-associated secretory phenotype (SASP). [PDF]
Biogerontology, 2019 Rolt A, Nair A, Cox LS.
europepmc +1 more source
Aging Triggers an Intestinal Energy Crisis and HDL3 Deficiency Disrupting Gut–Liver Axis Homeostasis
Aging Cell, Volume 25, Issue 3, March 2026.The age‐related mitochondrial energy crisis and the consequent disruption of intestinal HDL3 biosynthesis converge to disrupt the gut–liver HDL3‐LPS/TLR4 axis, compromising hepatic anti‐inflammatory function and driving liver injury, an effect reversible upon NMN administration.
Yumeng Li +7 more
wiley +1 more source