Results 11 to 20 of about 26,014 (255)

The role of senescence-associated secretory phenotype (SASP) in cellular senescene

Acta Biochimica Indonesiana, 2021
Cellular senescence is one of the defense mechanisms of cells against oncogenic signals by permanently stopping the proliferation of the cell. Senescence cells show a similar characteristic, one of them is senescence-associated secretory phenotype (SASP).
Filda Vionita Irene de Lime, Novi Silvia Hardiany   +1 more
doaj   +4 more sources

Endothelial senescence-associated secretory phenotype (SASP) is regulated by Makorin-1 ubiquitin E3 ligase. [PDF]

Metabolism, 2019
BACKGROUND Disturbed flow (d-flow)-induced senescence and activation of endothelial cells (ECs) have been suggested to have critical roles in promoting atherosclerosis.
Kotla S, Le NT, Vu HT, Ko KA, Gi YJ, Thomas TN, Giancursio C, Lusis AJ, Cooke JP, Fujiwara K, Abe JI.   +10 more
europepmc   +5 more sources

Folic Acid Supplementation Suppresses Sleep Deprivation-Induced Telomere Dysfunction and Senescence-Associated Secretory Phenotype (SASP). [PDF]

Oxid Med Cell Longev, 2019
Sleep deprivation is reported to cause oxidative stress and is hypothesized to induce subsequent aging-related diseases including chronic inflammation, Alzheimer's disease, and cardiovascular disease.
Zhang X, Wang Y, Zhao R, Hu X, Zhang B, Lv X, Guo Z, Zhang Z, Yuan J, Chu X, Wang F, Li G, Geng X, Liu Y, Sui L, Wang F.   +15 more
europepmc   +4 more sources

Modulation of fracture healing by senescence-associated secretory phenotype (SASP): a narrative review of the current literature. [PDF]

Eur J Med Res
The senescence-associated secretory phenotype (SASP) is a generic term for the secretion of cytokines, such as pro-inflammatory factors and proteases. It is a crucial feature of senescent cells.
Zhao S, Qiao Z, Pfeifer R, Pape HC, Mao K, Tang H, Meng B, Chen S, Liu H.   +8 more
europepmc   +6 more sources

Late Depression and Senescence-Associated Secretory Phenotype (SASP) [PDF]

Eur Psychiatry
Introduction Neurobiological mechanisms of late depression include abnormal regulation and interaction of multiple biological processes, as well as abnormalities of brain structures and organs.
Sidenkova A.
europepmc   +3 more sources

Senescence-associated secretory phenotype (SASP) and uterine fibroids: Association with PD-L1 activation and collagen deposition. [PDF]

Ageing Res Rev
Uterine fibroids (or uterine leiomyoma, UFs) are one of the most prevalent benign uterine tumors with high proliferation and collagen synthesis capabilities.
Saad EE, Michel R, Borahay MA.
europepmc   +4 more sources

Optimisation of a screening platform for determining IL-6 inflammatory signalling in the senescence-associated secretory phenotype (SASP). [PDF]

Biogerontology, 2019
Cellular senescence has been shown to be sufficient for the development of multiple age-related pathologies. Senescent cells adopt a secretory phenotype (the SASP) which comprises a large number of pro-inflammatory cytokines, chemokines and proteases ...
Rolt A, Nair A, Cox LS.
europepmc   +6 more sources

Sensitive detection and monitoring of senescence-associated secretory phenotype by SASP-RAP assay. [PDF]

PLoS ONE, 2012
Senescence-associated secretory phenotype (SASP) is characterized by abundant secretion of various proteins in senescent cells and implicated in tumor progression and inflammatory responses.
Liubao Gu, Masanori Kitamura
doaj   +4 more sources

Senescence in head and neck squamous cell carcinoma: relationship between senescence-associated secretory phenotype (SASP) mRNA expression level and clinicopathological features. [PDF]

Clin Transl Oncol
Cellular senescence is a state characterized by cell-cycle arrest and apoptotic resistance. Senescence in cancer may be induced by oncogenes or therapy.
Ostrowska K, Niewinski P, Piotrowski I, Ostapowicz J, Koczot S, Suchorska WM, Golusiński P, Masternak MM, Golusiński W.   +8 more
europepmc   +2 more sources

The senescence-associated secretory phenotype (SASP) from mesenchymal stromal cells impairs growth of immortalized prostate cells but has no effect on metastatic prostatic cancer cells. [PDF]

Aging (Albany NY), 2019
Senescent cells secrete inflammatory cytokines, proteases, and other factors, which are indicated as senescence-associated secretory phenotype (SASP). There are contrasting studies on the role of the SASP in cancer.
Alessio N, Aprile D, Squillaro T, Di Bernardo G, Finicelli M, Melone MA, Peluso G, Galderisi U.   +7 more
europepmc   +2 more sources