Results 21 to 30 of about 26,014 (255)

Senescence-associated extracellular vesicle (SA-EV) release plays a role in senescence-associated secretory phenotype (SASP) in age-associated diseases. [PDF]

The Journal of Biochemistry, 2020
Cellular senescence is an important tumor suppression mechanism that inhibits the proliferation of damaged cells. In senescent cells, irreparable DNA damage causes accumulation of genomic DNA fragments in the cytoplasm, which are recognized by the cyclic
Yoko Tanaka, Akiko Takahashi
semanticscholar   +3 more sources

Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP).

Cellular Signalling, 2012
The major hallmark of cellular senescence is an irreversible cell cycle arrest and thus it is a potent tumor suppressor mechanism. Genotoxic insults, e.g.
A. Salminen, A. Kauppinen, K. Kaarniranta   +2 more
semanticscholar   +3 more sources

Unbiased analysis of senescence associated secretory phenotype (SASP) to identify common components following different genotoxic stresses

Aging, 2016
Senescent cells secrete senescence-associated secretory phenotype (SASP) proteins to carry out several functions, such as sensitizing surrounding cells to senesce; immunomodulation; impairing or fostering cancer growth; and promoting tissue development ...
S. Özcan, N. Alessio, M. B. Acar, Eda Mert, Fatih Omerli, G. Peluso, U. Galderisi   +6 more
semanticscholar   +5 more sources

Cell enlargement modulated by GATA4 and YAP instructs the senescence-associated secretory phenotype

Nature Communications
Dynamic changes in cell size are associated with development and pathological conditions, including aging. Although cell enlargement is a prominent morphological feature of cellular senescence, its functional implications are unknown; moreover, how ...
Joae Joung, Yekang Heo, Yeonju Kim, Jaejin Kim, Haebeen Choi, Taerang Jeon, Yeji Jang, Eun-Jung Kim, Sang Heon Lee, Jae Myoung Suh, Stephen J. Elledge, Mi-Sung Kim, Chanhee Kang   +12 more
doaj   +2 more sources

Senescence-associated secretory phenotype in lung cancer: remodeling the tumor microenvironment for metastasis and immune suppression

Frontiers in Oncology
Cellular senescence exerts dual roles in lung cancer pathogenesis: initially suppressing tumorigenesis via p53/p21/p16-mediated cell cycle arrest, but promoting malignancy through the senescence-associated secretory phenotype (SASP).
Chen Chen, Ji Chen, Yanling Zhang, Qijun Zhang, Haixia Shi   +4 more
doaj   +2 more sources

ACSS2 drives senescence-associated secretory phenotype by limiting purine biosynthesis through PAICS acetylation

Nature Communications
Senescence-associated secretory phenotype (SASP) mediates the biological effects of senescent cells on the tissue microenvironment and contributes to ageing-associated disease progression.
Li Yang, Jianwei You, Xincheng Yang, Ruishu Jiao, Jie Xu, Yue zhang, Wen Mi, Lingzhi Zhu, Youqiong Ye, Ruobing Ren, Delin Min, Meilin Tang, Li Chen, Fuming Li, Pingyu Liu   +14 more
doaj   +2 more sources

Myeloma-Modified Adipocytes Exhibit Metabolic Dysfunction and a Senescence-Associated Secretory Phenotype. [PDF]

Cancer Res, 2021
Abstract Bone marrow adipocytes (BMAd) have recently been implicated in accelerating bone metastatic cancers, such as acute myelogenous leukemia and breast cancer. Importantly, bone marrow adipose tissue (BMAT) expands with aging and obesity, two key risk factors in multiple myeloma disease ...
Fairfield H, Dudakovic A, Khatib CM, Farrell M, Costa S, Falank C, Hinge M, Murphy CS, DeMambro V, Pettitt JA, Lary CW, Driscoll HE, McDonald MM, Kassem M, Rosen C, Andersen TL, van Wijnen AJ, Jafari A, Reagan MR.   +18 more
europepmc   +7 more sources

The Paradoxical Role of Cellular Senescence in Cancer

Frontiers in Cell and Developmental Biology, 2021
Cellular senescence occurs in proliferating cells as a consequence of various triggers including telomere shortening, DNA damage, and inappropriate expression of oncogenes.
Jing Yang, Jing Yang, Mengmeng Liu, Mengmeng Liu, Dongchun Hong, Dongchun Hong, Musheng Zeng, Xing Zhang   +7 more
doaj   +1 more source

TGF-β in the microenvironment induces a physiologically occurring immune-suppressive senescent state

Cell Reports, 2023
Summary: TGF-β induces senescence in embryonic tissues. Whether TGF-β in the hypoxic tumor microenvironment (TME) induces senescence in cancer and how the ensuing senescence-associated secretory phenotype (SASP) remodels the cellular TME to influence ...
Satoru Matsuda, Ajinkya Revandkar, Taronish D. Dubash, Arvind Ravi, Ben S. Wittner, Maoxuan Lin, Robert Morris, Risa Burr, Hongshan Guo, Karsen Seeger, Annamaria Szabolcs, Dante Che, Linda Nieman, Gad A. Getz, David T. Ting, Michael S. Lawrence, Justin Gainor, Daniel A. Haber, Shyamala Maheswaran   +18 more
doaj   +1 more source

Altered regulation of mesenchymal cell senescence in adipose tissue promotes pathological changes associated with diabetic wound healing

Communications Biology, 2022
Type-2 diabetic adipose tissue impairs transient senescence during wound healing with expression of different components of the senescence-associated secretory phenotype (SASP), and this is associated with deteriorated wound healing.
Arisa Kita, Yuki Saito, Norihiro Miura, Maki Miyajima, Sena Yamamoto, Tsukasa Sato, Takatoshi Yotsuyanagi, Mineko Fujimiya, Takako S. Chikenji   +8 more
doaj   +1 more source