Results 131 to 140 of about 8,908 (223)
Mitochondrial priming and response to BH3 mimetics in "one-two punch" senogenic-senolytic strategies [PDF]
A one-two punch sequential regimen of senescence-inducing agents followed by senolytic drugs has emerged as a novel therapeutic strategy in cancer. Unfortunately, cancer cells undergoing therapy-induced senescence (TIS) vary widely in their sensitivity ...
Alarcón Cor, Tomás +13 more
core +1 more source
Cancer Science, Volume 117, Issue 3, Page 818-835, March 2026.We uncovered pronounced and heterogeneous tumor senescence in EOCRC, independent of age. By integrating multi‐omics and single‐cell analyses, we developed EO‐Senscore, a prognostic tool that stratifies patients by immune phenotype and therapy response, enabling precision treatment using immunotherapy or senolytic agents. ABSTRACT Early‐onset colorectal
Du Cai +11 more
wiley +1 more source
A Senolytic Strategy for Metabolic Health: Why the Endothelium Matters
iNew Medicine, Volume 2, Issue 1, March 2026.
He Liang +3 more
wiley +1 more source
European Journal of Haematology, Volume 116, Issue 3, Page 302-310, March 2026.ABSTRACT Since 2004, patients receiving imatinib with relapse in non‐marrow sites were given dasatinib to preserve control of leukemic marrow. Remissions in CNS and other organs began to be reported and are continuously observed to present. With resistance to one BCR::ABL1 tyrosine kinase inhibitor and sensitivity to a dual BCR::ABL1/SRC inhibitor ...
I. Cunningham +4 more
wiley +1 more source
Journal of the American Geriatrics Society, Volume 74, Issue 3, Page 854-867, March 2026.ABSTRACT Introduction Although frailty is considered a potentially modifiable risk factor for dementia, its influence on health outcomes in individuals with established dementia remains unclear. This study aims to systematize the current evidence to understand the impact of frailty on the development of adverse outcomes in older adults with dementia ...
Miguel German Borda +11 more
wiley +1 more source
Recent Advances in Aging and Immunosenescence: Mechanisms and Therapeutic Strategies
CellsCellular senescence is an irreversible state of cell cycle arrest. Senescent cells (SCs) accumulate in the body with age and secrete harmful substances known as the senescence-associated secretory phenotype (SASP), causing chronic inflammation; at the ...
Shuaiqi Wang +6 more
doaj +1 more source
Senescent cells as a target for anti-aging interventions: From senolytics to immune therapies [PDF]
Aging and age-related diseases are major drivers of multimorbidity and mortality worldwide. Cellular senescence is a hallmark of aging. The accumulation of senescent cells is causally associated with pathogenesis of various age-associated disorders.
Fu, Tianlu Esther, Zhou, Zhongjun
core +1 more source
The “Reducing Inflammation for Greater Health Trial (RIGHT)” Study—Concept, Rationale, and Design
Journal of the American Geriatrics Society, Volume 74, Issue 3, Page 636-647, March 2026.ABSTRACT The Reducing Inflammation for Greater Health Trial's (RIGHT) study is a single‐center, randomized, double‐blind, placebo‐controlled trial designed to test whether clazkizumab, an interleukin‐6 (IL‐6) inhibitor, can improve or slow decline in physical, cognitive, and vascular function in older adults, when compared to a placebo.
Sebastian E. Sattui +11 more
wiley +1 more source
PharmaceuticalsBackground: Cellular senescence is a biological process with a dual role in organismal health. While transient senescence supports tissue repair and acts as a tumor-suppressive mechanism, the chronic accumulation of senescent cells contributes to aging ...
Larissa Della Vedova +4 more
doaj +1 more source