Results 61 to 70 of about 6,287 (219)

The Clinical Potential of Senolytic Drugs [PDF]

Journal of the American Geriatrics Society, 2017
Senolytic drugs are agents that selectively induce apoptosis of senescent cells. These cells accumulate in many tissues with aging and at sites of pathology in multiple chronic diseases. In studies in animals, targeting senescent cells using genetic or pharmacological approaches delays, prevents, or alleviates multiple age‐related phenotypes, chronic ...
James L, Kirkland, Tamara, Tchkonia, Yi, Zhu, Laura J, Niedernhofer, Paul D, Robbins   +4 more
openaire   +2 more sources

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Galacto-conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity. [PDF]

, 2020
Pharmacologically active compounds with preferential cytotoxic activity for senescent cells, known as senolytics, can ameliorate or even revert pathological manifestations of senescence in numerous preclinical mouse disease models, including cancer ...
Bernardos, Andrea, Blandez, Juan F, Doherty, Gary J, Fruk, Ljiljana, González-Gualda, Estela, González-López, Cristina, Lozano-Torres, Beatriz, Lérida-Viso, Araceli, Macias, David, Martins, Carla P, Martínez-Máñez, Ramón, Mirón-Barroso, Sofía, Muñoz-Espín, Daniel, Ou, Hui-Ling, Pàez-Ribes, Marta, Rovira, Miguel, Sancenón, Félix, Serrano, Manuel, Wilson, Joseph R, Zhang, Zhenguang   +19 more
core   +2 more sources

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Context-dependent roles of cellular senescence in normal, aged, and disease states. [PDF]

, 2023
Cellular senescence is a state of irreversible cell cycle arrest that often emerges after tissue damage and in age-related diseases. Through the production of a multicomponent secretory phenotype (SASP), senescent cells can impact the regeneration and ...
Cisneros, Andrés, Cobos, Aina Calls, Moiseeva, Victoria, Muñoz-Cánoves, Pura, Oñate, Claudia Santos, Perdiguero, Eusebio, Serrano, Antonio L, Tarrega, Aida Beà   +7 more
core   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

MASLD does not affect fertility and senolytics fail to prevent MASLD progression in male mice

Scientific Reports
Senescent cells have been linked to the pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD). However, the effectiveness of senolytic drugs in reducing liver damage in mice with MASLD is not clear. Additionally, MASLD has been
Jessica D. Hense, Driele N. Garcia, Bianka M. Zanini, Mariana M. Barreto, Giulia C. Perreira, José V. V. Isola, Camila de Brito, Michal Fornalik, Samim A. Mondal, Bianca M. Ávila, Thais L. Oliveira, Heather C. Rice, Charles I. Lacy, Rodrigo A. Vaucher, Jeffrey B. Mason, Michal M. Masternak, Michael B. Stout, Augusto Schneider   +17 more
doaj   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Senotherapeutic Effect of Retinaldehyde and Hyaluronate Fragments in Dermatoporosis

Dermatopathology, 2023
Cellular senescence is one of the important mechanisms of skin aging. In a recent study, we have shown that in patients with dermatoporosis, an extreme senescence condition of the skin, cells positive for p16Ink4a, a biomarker of senescence, were ...
Aysin Kaya, Jean-Hilaire Saurat, Gürkan Kaya   +2 more
doaj   +1 more source