Results 131 to 140 of about 1,457 (176)

The impacts of chronic infections on shaping cellular senescence

Immunity & Ageing
Cellular senescence is a fundamental biological process characterized by stable cell cycle arrest, genomic instability, and the acquisition of a proinflammatory secretory phenotype.
Ashley Johnson, Troy Rought, Jacob Aronov, Princess Pokharel, Angelina Chiu, Azadeh Nasuhidehnavi   +5 more
doaj   +1 more source

Therapy-induced senescence in normal fibroblasts promotes in vitro tumour cell growth and invasiveness: study of the role of Quercetin in modulating these processes. [PDF]

, 2022
Bientinesi, Elisa, Monti, Daniela
core  

The senomorphic impact of astaxanthin on irradiated rat spleen: STING, TLR4 and mTOR contributed pathway

International Journal of Immunopathology and Pharmacology
Objectives: Exposure of spleen tissues to ionizing radiation during radiotherapy can induce cellular stress and immune-dysfunction leading to cellular senescence. Introduction: The process of a cancerous development is facilitated by the accumulation of senescent cells.
Maha M Aziz, Marwa M El-Sheikh, Marwa A Mohamed, Sahar S Abdelrahman, Mai H Mekkawy   +4 more
openaire   +2 more sources

Ruxolitinib-based senomorphic therapy mitigates cardiomyocyte senescence in septic cardiomyopathy by inhibiting the JAK2/STAT3 signaling pathway

International Journal of Biological Sciences
Background: Cellular senescence has emerged as a pivotal focus in cardiovascular research. This study investigates the previously unrecognized role of cellular senescence in septic cardiomyopathy (SCM) and evaluates senomorphic therapy using ruxolitinib (Rux) as a potential treatment option.
Yang, Boshen, Li, Taixi, Wang, Zhixiang, Zhu, Yuankang, Niu, Kaifan, Hu, Sien, Lin, Zhiqi, Zheng, Xinjie, Jin, Xian, Shen, Chengxing   +9 more
openaire   +2 more sources

Cellular Senescence, Mitochondrial Dysfunction, and Their Link to Cardiovascular Disease [PDF]

Cardiovascular diseases (CVDs), a group of disorders affecting the heart or blood vessels, are the primary cause of death worldwide, with an immense impact on patient quality of life and disability.
Booth LK, Camacho-Encina M, Folaranmi O, Redgrave RE, Richardson DG, Spyridopoulos I   +5 more
core  

Investigating the potential senomorphic properties of SCFA butyrate on aged T cells. [PDF]

Ageing is accompanied by remodelling of the T cell pool and a hallmark of immune ageing is the expansion of senescent T cells in aged hosts. Senescent T cells express markers of DNA damage and cell cycle arrest markers, elevated production of pro ...
Paddison Rees, Nia
core  

Targeting senescence‐associated secretory phenotypes to remodel the tumour microenvironment and modulate tumour outcomes

Clinical and Translational Medicine
Tumour cell senescence can be induced by various factors, including DNA damage, inflammatory signals, genetic toxins, ionising radiation and nutrient metabolism.
Jiaqiang Xiong, Lu Dong, Qiongying Lv, Yutong Yin, Jiahui Zhao, Youning Ke, Shixuan Wang, Wei Zhang, Meng Wu   +8 more
doaj   +1 more source

The Impact of Senescence-Associated Secretory Phenotype (SASP) on Head and Neck Cancers: From Biology to Therapy. [PDF]

Cancers (Basel)
Alam MT, Mansoor MAM, Ashiqueali SA, Golusinski P, Golusinska-Kardach E, Strzelczyk JK, Rubis B, Golusinski W, Masternak MM.   +8 more
europepmc   +1 more source

Anti-senescence therapies: a new concept to address cardiovascular disease. [PDF]

Cardiovasc Res
Stojanović SD, Thum T, Bauersachs J.
europepmc   +1 more source

Cellular senescence in lung cancer immune microenvironment and senotherapeutic opportunities. [PDF]

iScience
Xu Z, Liu F, Huang S, Chu Q.
europepmc   +1 more source