The Emerging Role of Senotherapy in Cancer: A Comprehensive Review [PDF]
Clinics and Practice, 2023 Senotherapy, a promising therapeutic strategy, has drawn a lot attention recently due to its potential for combating cancer. Senotherapy refers to the targeting of senescent cells to restore tissue homeostasis and mitigate the deleterious effects ...
Sarubala Malayaperumal +7 more
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Antioxidant Senotherapy by Natural Compounds: A Beneficial Partner in Cancer Treatment [PDF]
AntioxidantsAging is a general biological process inherent in all living organisms. It is characterized by progressive cellular dysfunction. For many years, aging has been widely recognized as a highly effective mechanism for suppressing the progression of malignant
Yulia Aleksandrova, Margarita Neganova
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A biomimetic senotherapy replenishing MAT2A promotes wound regeneration in preclinical models [PDF]
Nature CommunicationsTimely infiltration and effective turnover of macrophages after trauma are essential for wound regeneration. In pathological conditions, such as diabetic wounds, how disturbances in cellular collaboration leads to persistent inflammatory infiltration ...
Dongming LV +15 more
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Natural killer cell-based senotherapy: a promising strategy for healthy aging [PDF]
Frontiers in ImmunologyOne of the most significant risk factors for diseases is aging. Interestingly, some organisms, such as naked mole-rats and most turtles, do not exhibit typical aging-like symptoms or increased mortality as they become older.
Tsutomu Nakazawa +4 more
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Senotherapy for chronic lung disease. [PDF]
Pharmacol RevChronic respiratory diseases are an enormous burden on healthcare and the third ranked cause of death globally. There is now compelling evidence that acceleration of lung aging and associated cellular senescence is a key driving mechanism of several ...
Barnes PJ.
europepmc +4 more sources
Фармакокинетика и ФармакодинамикаSenescence — cellular aging — is a special form of cell death, characterized by the cell’s irreversible loss of its proliferation potential and the development of resistance to apoptosis.
S. A. Kryzhanovskii, M. B. Vititnova
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A Senescent Cluster in Aged Human Hematopoietic Stem Cell Compartment as Target for Senotherapy. [PDF]
Int J Mol SciTo identify the differences between aged and young human hematopoiesis, we performed a direct comparison of aged and young human hematopoietic stem and progenitor cells (HSPCs).
Poisa-Beiro L +12 more
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Inhibition of miMOMP-induced SASP to combat age-related disease [PDF]
Frontiers in AgingCellular senescence, first described in 1961, was initially observed in normal human fibroblasts that ceased proliferating after a finite number of divisions in culture.
Xiaoli Liao +4 more
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Inducible skeletal muscle-specific p53 deletion alleviates high-fat diet-induced insulin resistance by modulating mitochondria-associated membrane in obese mice [PDF]
Redox Biologyp53 has been implicated in metabolic regulation, but its role in obesity-induced skeletal muscle insulin resistance remains incompletely understood. This study aimed to determine the functional contribution of skeletal muscle p53 to insulin resistance ...
Soyoung Park +12 more
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Cellular Senescence in Diabetes Mellitus: Distinct Senotherapeutic Strategies for Adipose Tissue and Pancreatic β Cells [PDF]
Frontiers in Endocrinology, 2022 Increased insulin resistance and impaired insulin secretion are significant characteristics manifested by patients with type 2 diabetes mellitus (T2DM). The degree and extent of these two features in T2DM vary among races and individuals.
Takaaki Murakami +3 more
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