Results 11 to 20 of about 728 (163)
BiomedicinesParkinson’s disease (PD) is an aging-related neurodegenerative disease characterized by a progressive loss of dopamine (DA)-secreting neurons in the substantia nigra. Most of the currently available treatments attempt to alleviate the disease symptoms by
David J. Rademacher +2 more
doaj +3 more sources
The potential for senotherapy as a novel approach to extend life quality in veterinary medicine
Frontiers in Veterinary ScienceCellular senescence, a condition where cells undergo arrest and can assume an inflammatory phenotype, has been associated with initiation and perpetuation of inflammation driving multiple disease processes in rodent models and humans.
Zoë J. Williams +4 more
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Targeting p21 for diabetes: Another choice of senotherapy.
Cell Metabolism, 2022 Senotherapy, the elimination of senescent cells, is a cutting-edge treatment for aging-related and lifestyle diseases. In this issue of Cell Metabolism, Wang et al. report that p21Cip1 highly expressing cells, which represent a senescent cell population,
H. Kondoh, Eiji Hara
semanticscholar +3 more sources
Targeted delivery strategy: A beneficial partner for emerging senotherapy.
Biomedicine & Pharmacotherapy, 2022 Numerous cutting-edge studies have confirmed that the slow accumulation of cell cycle arrested and secretory cells, called senescent cells (SCs), in tissues is an important negative factor, or even the culprit, in age- associated diseases such as non ...
Qixiong Zhang +4 more
semanticscholar +3 more sources
Senotherapy preserves resilience in aging
Geriatrics & Gerontology InternationalIn aging societies, social and economic burdens of aging‐related diseases are increasing significantly. Senotherapy, which targets aging by eliminating senescent cells (senolytics) or removing sources of chronic inflammation (senostatics), are proposed ...
Takumi Mikawa +2 more
semanticscholar +3 more sources
Oxidative Medicine and Cellular Longevity, 2022 Ovarian damage induced by platinum‐based chemotherapy seriously affects young women with cancer, manifesting as infertility, early menopause, and premature ovarian insufficiency.
Dingfu Du +11 more
semanticscholar +3 more sources
Foretinib Alleviates Osteoblast Senescence and Protects Against Bone Loss in Ovariectomized Mice by Promoting Osteoblast Differentiation [PDF]
CellsOsteoporosis is a major global health challenge, causing millions of fragility fractures each year and imposing an escalating socioeconomic burden worldwide.
Jiin Oh +7 more
doaj +2 more sources
Older adults with cancer and common comorbidities-challenges and opportunities in improving their cancer treatment outcomes. [PDF]
J Natl Cancer InstThe older American population is rapidly increasing, and millions of older adults will be cancer survivors with comorbidities. This population faces specific challenges regarding treatment and has unique clinical needs.
Chen W +7 more
europepmc +2 more sources
Treating Senescence like Cancer: Novel Perspectives in Senotherapy of Chronic Diseases [PDF]
International Journal of Molecular Sciences, 2020 The WHO estimated around 41 million deaths worldwide each year for age-related non-communicable chronic diseases. Hence, developing strategies to control the accumulation of cell senescence in living organisms and the overall aging process is an urgently
Alessia Mongelli +6 more
semanticscholar +4 more sources
A novel senotherapeutic strategy with azithromycin for preventing endometriosis progression [PDF]
Reproductive Biology and EndocrinologyBackground Endometriosis is an estrogen-dependent chronic inflammatory disease, however the mechanisms underlying inflammation remain unclear. Non-hormonal drugs that can prevent endometriosis progression and resolve endometriotic infertility are ...
Reina Sonehara +11 more
doaj +2 more sources