Translational Medicine of Aging, 2023 Chronic aging represents the leading risk factor for the vast majority of age-related diseases, which together contribute to increased morbidities and elevated mortalities in late life.
Yu Sun
doaj +2 more sources
Impact and potential value of immunosenescence on solid gastrointestinal tumors [PDF]
Frontiers in ImmunologySolid gastrointestinal tumors often respond poorly to immunotherapy for the complex tumor microenvironment (TME), which is exacerbated by immune system alterations. Immunosenescence is the process of increased diversification of immune genes due to aging
Tianshuai Zhang +8 more
doaj +2 more sources
Eliminating senescent cells by white adipose tissue-targeted senotherapy alleviates age-related hepatic steatosis through decreasing lipolysis. [PDF]
GeroscienceTang Q +9 more
europepmc +2 more sources
Review of evidence linking exposure to environmental stressors and associated alterations in the dynamics of immunosenescence (ISC) with the global increase in multiple sclerosis (MS) [PDF]
Immunity & AgeingHistorical survey confirms that, over the latter part of the 20th century, autoimmune-based diseases, including multiple sclerosis (MS), have shown a worldwide increase in incidence and prevalence.
Christopher Bolton
doaj +2 more sources
Apoptosis-coupled senescence causes cancer cell senotherapy
bioRxiv, 2023 AbstractAlthough new generations of anti-cancer modalities have been accumulated involving immuno-oncology cancers remain prevailing. This implies the current understanding of cancer cell biology is far from satisfactory. Curation of cancers is extremely rare.
Byung-Soo Youn
semanticscholar +2 more sources
Frontiers in Endocrinology, 2023 Recent advances in aging research have provided novel insights for the development of senotherapy, which utilizes cellular senescence as a therapeutic target.
Sachi Matsubayashi +3 more
doaj +1 more source
Hallmarks and Biomarkers of Skin Senescence: An Updated Review of Skin Senotherapeutics
Antioxidants, 2023 Aging is a complex process characterized by an ongoing decline in physiological functions, leading to degenerative diseases and an increased probability of death. Cellular senescence has been typically considered as an anti-proliferative process; however,
Darya Bulbiankova +5 more
doaj +1 more source
The interaction between cellular senescence and chronic kidney disease as a therapeutic opportunity
Frontiers in Pharmacology, 2022 Chronic kidney disease (CKD) is an increasingly serious public health problem in the world, but the effective therapeutic approach is quite limited at present.
Jing-Li Zhao +4 more
doaj +1 more source
Senotherapeutic Effect of Retinaldehyde and Hyaluronate Fragments in Dermatoporosis
Dermatopathology, 2023 Cellular senescence is one of the important mechanisms of skin aging. In a recent study, we have shown that in patients with dermatoporosis, an extreme senescence condition of the skin, cells positive for p16Ink4a, a biomarker of senescence, were ...
Aysin Kaya +2 more
doaj +1 more source
A stress-induced cilium-to-PML-NB route drives senescence initiation
Nature Communications, 2023 Exposure to irreparable stresses induces transient ciliogenesis, enabling communication with PML-NBs via a FBF1 pathway to trigger senescence in mammalian cells.
Xiaoyu Ma +14 more
doaj +1 more source