Results 41 to 50 of about 728 (163)
Cellular Senescence and Immunosenescence in Melanoma: Insights From the Tumor Microenvironment. [PDF]
Cancer MedABSTRACT Background Melanoma is one of the most immunogenic malignancies, yet resistance to immune checkpoint inhibitors (ICIs) remains a major obstacle to durable therapeutic success. Emerging evidence indicates that aging‐related processes, including cellular senescence and immunosenescence, can reshape the tumor microenvironment (TME) to favor ...
Xiong L, Cheng J.
europepmc +2 more sources
Reshaping of the tumor microenvironment by cellular senescence: An opportunity for senotherapies
Developmental Cell, 2023 Cellular senescence is a stress response associated with aging and disease, including cancer. Senescent cells undergo a stable cell cycle arrest, undergo a change in morphology and metabolic reprogramming, and produce a bioactive secretome termed the senescence-associated secretory phenotype (SASP).
Gil, J, D’Ambrosio, M
openaire +4 more sources
An evaluation of the role of miR-361-5p in senescence and systemic ageing
Experimental Gerontology, 2023 Senescent cells are key regulators of ageing and age-associated disease. MicroRNAs (miRs) are a key component of the molecular machinery governing cellular senescence, with several known to regulate important genes associated with this process.We sought ...
Emad Manni +5 more
doaj +1 more source
Senescence and Cancer: A Review of Clinical Implications of Senescence and Senotherapies [PDF]
Cancers, 2020 Cellular senescence is a key component of human aging that can be induced by a range of stimuli, including DNA damage, cellular stress, telomere shortening, and the activation of oncogenes. Senescence is generally regarded as a tumour suppressive process, both by preventing cancer cell proliferation and suppressing malignant progression from pre ...
Wyld, L. +8 more
openaire +4 more sources
Cellular Senescence and Senotherapies in the Kidney: Current Evidence and Future Directions [PDF]
Frontiers in Pharmacology, 2020 Cellular senescence refers to a cellular phenotype characterized by an altered transcriptome, pro-inflammatory secretome, and generally irreversible growth arrest. Acutely senescent cells are widely recognized as performing key physiological functions in vivo promoting normal organogenesis, successful wound repair, and cancer defense.
Marie Helena Docherty +7 more
openaire +3 more sources
Long-term cardiovascular complications following sepsis: is senescence the missing link?
Annals of Intensive Care, 2021 Highlights With improved management of patients, sepsis survivors are increasing each year. Early cardiovascular complications, of yet undeciphered mechanisms, are an emerging health issue in post-sepsis syndrome.
Hamid Merdji +3 more
doaj +1 more source
Virus-like nanoparticles as a theranostic platform for cancer
Frontiers in Bioengineering and Biotechnology, 2023 Virus-like nanoparticles (VLPs) are natural polymer-based nanomaterials that mimic viral structures through the hierarchical assembly of viral coat proteins, while lacking viral genomes.
Kyeong Rok Kim +5 more
doaj +1 more source
Cellular senescence in the aging retina and developments of senotherapies for age-related macular degeneration [PDF]
Journal of Neuroinflammation, 2021 AbstractAge-related macular degeneration (AMD), a degenerative disease in the central macula area of the neuroretina and the supporting retinal pigment epithelium, is the most common cause of vision loss in the elderly. Although advances have been made, treatment to prevent the progressive degeneration is lacking.
Keng Siang Lee +4 more
openaire +5 more sources
Diverse Roles of Cellular Senescence in Skeletal Muscle Inflammation, Regeneration, and Therapeutics
Frontiers in Pharmacology, 2021 Skeletal muscle undergoes vigorous tissue remodeling after injury. However, aging, chronic inflammatory diseases, sarcopenia, and neuromuscular disorders cause muscle loss and degeneration, resulting in muscular dysfunction.
Yuki Saito +2 more
doaj +1 more source
Nature Communications, 2020 Senotherapy, the removal of aged T cells, is an effective approach to attenuate age-related diseases. Here the authors report a CD153 targeting vaccine that prevents the accumulation of senescent adipose tissue T cells in mice on high-fat diet, which is ...
Shota Yoshida +10 more
doaj +1 more source