Results 51 to 60 of about 728 (163)
Smooth muscle cell-specific deletion of TXNIP ameliorates medial vascular calcification
Experimental and Molecular MedicineVascular calcification is an important pathological characteristic of cardiovascular diseases, often exacerbated by metabolic disorders such as chronic kidney disease and diabetes mellitus.
Ae-Rang Hwang, Chang-Hoon Woo
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Journal of Skin and Stem CellBackground: The skin, as the body’s largest organ, plays a crucial role in systemic physiological processes. Dysfunction in the skin, often driven by cellular senescence, accelerates skin aging and contributes to systemic aging.
S. Farokhimanesh
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Self‐Immolative Systems in Diagnostic and Therapeutic Applications
ChemMedChem, Volume 21, Issue 5, 13 March 2026.Self‐Immolative Systems enable the precise, residue‐free release of active molecules, drugs, probes, or sensors, via cyclization or elimination, triggered by specific stimuli. Their versatility drives advances in drug delivery, diagnostics, nanotechnology, materials chemistry, and biosensing, offering chemists control over molecular activation and ...
Windbedema Prisca Ouédraogo +2 more
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Modulation of tumor plasticity by senescent cells: Deciphering basic mechanisms and survival pathways to unravel therapeutic options [PDF]
Genetics and Molecular BiologySenescence is a cellular state in which the cell loses its proliferative capacity, often irreversibly. Physiologically, it occurs due to a limited capacity of cell division associated with telomere shortening, the so-called replicative senescence. It can
Andrew Oliveira Silva +4 more
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Pleiotropic effects of BAFF on the senescence-associated secretome and growth arrest
eLife, 2023 Senescent cells release a variety of cytokines, proteases, and growth factors collectively known as the senescence-associated secretory phenotype (SASP). Sustained SASP contributes to a pattern of chronic inflammation associated with aging and implicated
Martina Rossi +17 more
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Cell Death and Disease, 2022 Aging inducing the development of senescent cells (SNCs) in various tissues is considered as the main cause of the age-related diseases. Senotherapy has become a promising anti-aging therapy.
Zongke Bai +7 more
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Aging Cell, Volume 25, Issue 1, January 2026.Mitochondrial respiratory supercomplex assembly factor COX7RP improves metabolic homeostasis and contributes to lifespan extension in mice. The overexpression of COX7RP reduces white adipose tissue mass and downregulates senescence‐associated secreted phenotype‐related genes in the tissue, suggesting that COX7RP plays a role in preventing aging through
Kazuhiro Ikeda +6 more
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From Neuron‐Centric to Glia‐Centric: How Aging Glial Networks Drive Neurodegenerative Disease
Journal of Neurochemistry, Volume 170, Issue 1, January 2026.During aging, progressive alterations in glial networks reshape intercellular communication within the central nervous system. In the young brain, astrocytes and microglia actively regulate metabolic, immune, and synaptic processes that sustain neural circuit stability.
Lívia de Sá Hayashide +5 more
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Therapy-Induced Stromal Senescence Promoting Aggressiveness of Prostate and Ovarian Cancer
Cells, 2022 Cancer progression is supported by the cross-talk between tumor cells and the surrounding stroma. In this context, senescent cells in the tumor microenvironment contribute to the development of a pro-inflammatory milieu and the acquisition of aggressive ...
Elisa Pardella +17 more
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[Senotherapy: Advances and new clinical perspectives].
Medecine sciences : M/S, 2020 Cellular senescence has been now shown to be at the root of many degenerative processes that characterize ageing. Thus, in addition to an irreversible proliferative arrest following various stresses or inappropriate stimuli, cellular senescence leads to ...
Damien Véret, J. Brondello
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