Results 61 to 70 of about 728 (163)
Immunosenescence: Molecular Mechanisms, Diseases, and Therapeutic Innovations
MedComm, Volume 6, Issue 12, December 2025.Along with organismal aging or pathogenic processes especially tumor, multiple immune cell types exhibit those well‐established hallmarks of cellular senescent phenotype, mainly characterized by irreversible cell cycle arrest, metabolic disorder, and over production of SASP.
Ninghan Gong +8 more
wiley +1 more source
Cancer Science, Volume 116, Issue 12, Page 3274-3285, December 2025.Just as the term “cancer cell” encompasses a wide spectrum of cells, the term “senescent cell” should also be regarded as an umbrella term that includes cells with heterogeneous molecular profiles. In this review, we provide an updated overview of the molecular mechanisms underlying distinct senescent cell subtypes induced by various stimuli, including
Enaam Alghamdi, Keiko Kono
wiley +1 more source
Ignoring the planet: A critical blind spot for research on ageing
Journal of Internal Medicine, Volume 298, Issue 6, Page 578-590, December 2025.Abstract Although research on ageing has largely concentrated on understanding the fundamental biology of the ageing process and devising pharmaceutical interventions in order to slow it down, increasing evidence has underscored the crucial role of environmental inputs across the life course and across generations, in shaping both individual and ...
Paul Shiels +6 more
wiley +1 more source
Potential Clinical Implications of Senotherapies for Cardiovascular Disease
Circulation JournalAging is a major risk factor for cardiovascular diseases (CVDs) and accumulating evidence indicates that biological aging has a significant effect on the onset and progression of CVDs. In recent years, therapies targeting senescent cells (senotherapies), particularly senolytics that selectively eliminate senescent cells, have been developed and show ...
Masayoshi, Suda +4 more
openaire +2 more sources
Cellular Senescence in Cancer: Mechanisms, Roles in Tumor Progression, and Therapeutic Implications
MedComm – Oncology, Volume 4, Issue 3, September 2025.Senescent tumor cells in TME exhibit dual roles. “Angels” secrete SASPs/DAMPs to boost immunological clearance and antitumor immunity via MHC‐I upregulation; “Demons” produce tumor‐promoting SASPs recruiting MDSCs to drive malignancy. ABSTRACT Cellular senescence, a state of irreversible cell cycle arrest accompanied by a senescence‐associated ...
Jingrui Yan +5 more
wiley +1 more source
A Senolytic Strategy for Metabolic Health: Why the Endothelium Matters
iNew Medicine, EarlyView.
He Liang +3 more
wiley +1 more source
The Interplay of Aging and Cancer: Mechanisms, Implications, and Therapeutic Strategies
MedComm – Oncology, Volume 4, Issue 3, September 2025.Aging and cancer form a vicious cycle: aging alters the tumor microenvironment, promotes senescence, and reshapes cancer progression and therapy response. In return, cancer and its treatments accelerate aging through inflammation and genomic damage. Novel strategies‐senolytics, CAR‐T, and artificial intelligence‐offer exciting opportunities to disrupt ...
Liangce Wang +4 more
wiley +1 more source
Experimental and Molecular MedicineTelomere dysfunction is a well-known molecular trigger of senescence and has been associated with various age-related diseases, including atherosclerosis.
Jin Young Sung +4 more
doaj +1 more source
Aging Cell, Volume 24, Issue 9, September 2025.As a natural senomorphic agent, PQQ targets the intracellular molecule. HSPA8 of senescent cells, resulting in significantly reduced expression of the SASP. PQQ holds prominent potential to delay chronological aging and ameliorate age‐related conditions by acting as an effective senomorphic agent.
Birong Jiang +6 more
wiley +1 more source
β‐Galactosidase Based Molecular Imaging for Visualization of Cellular Senescence
iRADIOLOGY, Volume 4, Issue 1, Page 63-65, February 2026.
Jiani Huang +3 more
wiley +1 more source